AutismKB 2.0

Annotation Detail for ISOC1


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Basic Information Top
Gene Symbol:ISOC1 ( - )
Gene Full Name: isochorismatase domain containing 1
Band: 5q23.3
Quick LinksEntrez ID:51015; OMIM: NA; Uniprot ID:ISOC1_HUMAN; ENSEMBL ID: ENSG00000066583; HGNC ID: 24254
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ISOC1 mRNAaffects expression 21346803
D001151 Arsenic Arsenic results in decreased expression of ISOC1 mRNAdecreases expression 19654921
D016572 Cyclosporine Cyclosporine results in decreased expression of ISOC1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ISOC1 mRNAincreases expression 17557909
C006253 pirinixic acid pirinixic acid results in increased expression of ISOC1 mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9416835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D050197 Atherosclerosis Arsenic 3.4412928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.2816705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2817306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7717687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.6418022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 14.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.8916919318 15861022 17681005 11677210 16105132 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 14.8919176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0421346803 18551238
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D005234 Fatty Liver Cyclosporine 15.2619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.2615345470
MESH:D005234 Fatty Liver pirinixic acid 15.2620131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.6212168785 12639820
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19772884 19176532 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 5.6716076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 5.6710903974
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007642 Keratosis Arsenic 5.5312749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 4.9716368122
MESH:D008113 Liver Neoplasms pirinixic acid 4.9720007298 15890375 16377806
MESH:D008175 Lung Neoplasms Arsenic 2.2119168569 17306315 17976673
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2715371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009436 Neural Tube Defects Arsenic 3.6716620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010051 Ovarian Neoplasms Arsenic 2.8317306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5316905509 6392382 15371236
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D012871 Skin Diseases Arsenic 2.8217548696 18709164 19834688 16759981 17938729 6392382 17050553 17453740 16702368 16353154 15952646
MESH:D012878 Skin Neoplasms Arsenic 3.1517029826 16251483 17976673 19538983 15504454 17050553
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5916049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5917976673 17306315 11144890 18640142 15987713 19429237 19322015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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