AutismKB 2.0

Annotation Detail for FAM158A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FAM158A ( C14orf122 )
Gene Full Name: family with sequence similarity 158, member A
Band: 14q11.2
Quick LinksEntrez ID:51016; OMIM: NA; Uniprot ID:F158A_HUMAN; ENSEMBL ID: ENSG00000100908; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FAM158A mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FAM158A mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of FAM158A mRNAdecreases expression 19420014
C006253 pirinixic acid pirinixic acid results in increased expression of FAM158A mRNAincreases expression 17426115
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of FAM158A mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of FAM158A mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of FAM158A mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.7219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.7219176532
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2818759878 14531868 12868966 11906362 8970840 2524372 11298694 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.708291058 6482804 18692083 9653073 9022650 18648102 18289764 1440618 16192314 7440962 9328219 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7010663392 12958197 16485898 15968718 12594235 19416960 12392966 11287661 11529661 18071297 11743745 17522070 16393943 10915739 19164858 14725611 12153990 16081117 11739529 16109766 2444490 12705907 12540782 11421492 18713872 11461765 19923254 16177239 17562736 17906064 14550746 16781746 19370779 19739265 10774834 19085960 11834606 14986274 19420014 16227642 15619225
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1516080930
MESH:D006333 Heart Failure pirinixic acid 7.6220558911
MESH:D006333 Heart Failure Selenium 7.6217162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19772884 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007251 Influenza, Human Selenium 13.0916624496
MESH:D007251 Influenza, Human Vitamin E 13.0916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 6.5812587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.5812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4616169303
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16611625 11587558 16610002 19460945 12587719 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9216377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.73598648 6587162 3712494 1399818
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156582329 6587162 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved