AutismKB 2.0

Annotation Detail for RRP15


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Basic Information Top
Gene Symbol:RRP15 ( KIAA0507,MGC22291 )
Gene Full Name: ribosomal RNA processing 15 homolog (S. cerevisiae)
Band: 1q41
Quick LinksEntrez ID:51018; OMIM: 611193; Uniprot ID:RRP15_HUMAN; ENSEMBL ID: ENSG00000067533; HGNC ID: 24255
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRP15 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of RRP15 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RRP15 mRNAincreases expression 17555576
D005472 Fluorouracil Fluorouracil results in decreased expression of RRP15 mRNAdecreases expression 16510598
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6014692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.6017638652
MESH:D000740 Anemia Fluorouracil 4.1116511603 17963324 15504547
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001943 Breast Neoplasms Fluorouracil 2.4316110121 15136595 18357371 19217205 16557594 18608205 16595493
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1217045692 18930000 17971768 17088986 16799960 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5818986760 16757204 16280240 17066447
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4412371664
MESH:D002779 Cholestasis Cyclosporine 8.7619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7616919318 17333356 15861022 16105132 11677210 17681005 17110522
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2816510598 17018589 18772588 17287894 15001691 17172411 17725105 17016597 17169374 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 16282729 17454858 16524972 16391804 18383874 17401013 17695437 18288408 20501625 18949393 18802399 16303861 17255274 18448328 18509181 15148649 16331619 15289873 17016601 14970324 17094418
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7816785472 16337965 16481741 17638652 15173087
MESH:D005234 Fatty Liver Cyclosporine 9.0219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.0215345470
MESH:D005355 Fibrosis Cyclosporine 3.7012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6418337622 15162350 15102660
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.548314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.5612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.5616985049
MESH:D008113 Liver Neoplasms Fluorouracil 2.6018383874 15113037 17045692 16603448
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9418986760 16757204
MESH:D009369 Neoplasms Fluorouracil 2.7718600527 16928823 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6519348381 18481113
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7715113037 16929163 16500647 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3519082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3815538739 18722050 16160472 18286688
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 15786421 18396642 17172411 17498489 17522103 19015929 16424979 16951190 19084572
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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