AutismKB 2.0

Annotation Detail for PPPDE1


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Basic Information Top
Gene Symbol:PPPDE1 ( C1orf121,FAM152A,FLJ21998,PNAS-4 )
Gene Full Name: PPPDE peptidase domain containing 1
Band: 1q44
Quick LinksEntrez ID:51029; OMIM: NA; Uniprot ID:PPDE1_HUMAN; ENSEMBL ID: ENSG00000121644; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPPDE1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPPDE1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of PPPDE1 mRNAincreases expression 20458559
D001554 Benzene Benzene results in increased expression of PPPDE1 mRNAincreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPPDE1 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of PPPDE1 mRNAincreases expression 20106945
C051890 irinotecan irinotecan analog results in decreased expression of PPPDE1 mRNAdecreases expression 18927307
D010634 Phenobarbital Phenobarbital results in decreased expression of PPPDE1 mRNAdecreases expression 19270015
C010327 salinomycin salinomycin results in decreased expression of PPPDE1 mRNAdecreases expression 19682730
D012643 Selenium Selenium results in decreased expression of PPPDE1 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of PPPDE1 mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin affects the expression of PPPDE1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3119825857 11798837
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.1217620307
MESH:D000741 Anemia, Aplastic Benzene 4.4511369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7816206674
MESH:D001855 Bone Marrow Diseases Benzene 5.4016183116
MESH:D001943 Breast Neoplasms Benzene 2.8111921183 17162533
MESH:D001943 Breast Neoplasms salinomycin 2.8119682730
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.6911135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6917173139 6705139 1701930 20007298 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8012371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D003110 Colonic Neoplasms irinotecan 2.6117287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7020501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7018259882 17159606 16391804 17454858 15273666 16303861 18509181
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.9310525206
MESH:D019465 Craniofacial Abnormalities Benzene 2.9315643154
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003872 Dermatitis Benzene 4.9015902427
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.372444490 12540782 11421492 18713872 11461765 11739529 16177239 12594235 15968718 11529661 19085960 11743745 16227642 10915739 14986274 10774834 19370779 19164858 16781746 11287661 16485898 14550746 16393943 15619225 14725611 10663392 18071297 12153990 11834606 17906064 19416960 19739265 17562736 12392966 12705907 19420014 12958197 19923254 16109766 16081117 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005234 Fatty Liver arsenic trioxide 8.1215073043
MESH:D005234 Fatty Liver Cyclosporine 8.1219224547
MESH:D005355 Fibrosis Cyclosporine 3.2812168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006402 Hematologic Diseases Benzene 4.7716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly Phenobarbital 3.6216109766
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006973 Hypertension Benzene 5.5117940673
MESH:D006973 Hypertension Cyclosporine 5.5110903974
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.998314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007938 Leukemia arsenic trioxide 6.7415070760
MESH:D007938 Leukemia Benzene 6.7417119257 18335105 15935818 14694614
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.0719077051
MESH:D007951 Leukemia, Myeloid Benzene 10.0717506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1716467208 16968895 19850784 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1719478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2815622746 11468182 17217047 19642359 17869043 16112521 16891316 17712046 11161223 15336539 16966277 12712474 15213294 19075265 17649720 12018890 19225113 9834237 16823087 16331271 16330433 15748426 12679006 17107899 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9521047994
MESH:D008107 Liver Diseases Acetaminophen 4.0112587719 19460945 16610002 16611625 19784758 19014921 11587558 12969438
MESH:D008107 Liver Diseases Phenobarbital 4.0119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7814682389
MESH:D008113 Liver Neoplasms Phenobarbital 4.7819073162 19812893 21047994 19482888 15975961 8742319
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.3720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 10.3712562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.376150874 1399818 18308698 17172636 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9814698565
MESH:D008175 Lung Neoplasms arsenic trioxide 2.7611798837 19825857
MESH:D008175 Lung Neoplasms Benzene 2.7612562636
MESH:D008223 Lymphoma Benzene 3.8117119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 10.6211921183
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 10.6219682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.6215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D052016 Mucositis irinotecan 5.1617159606
MESH:D009101 Multiple Myeloma arsenic trioxide 7.7515949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Benzene 7.7517119195
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016882451 16105982
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2118259882
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7610525206
MESH:D009436 Neural Tube Defects Benzene 7.7615643154
MESH:D009447 Neuroblastoma irinotecan 3.538761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.888761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5112819281 16049721
MESH:D009784 Occupational Diseases Benzene 9.5115913788 15727169 15576619 17119257 16737584 15935809 17178637 15612468 17479406
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Benzene 5.2112562636
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4215580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4216965848
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.3012371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.302563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0519015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2519131511
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1718551238
MESH:D012640 Seizures Phenobarbital 6.173137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5817007042
MESH:D013274 Stomach Neoplasms Benzene 3.5812562636
MESH:D013274 Stomach Neoplasms irinotecan 3.5815723263
MESH:D013953 Thymus Neoplasms Benzene 5.1110850423
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5019014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.501399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2111780464 12973940 20435036 12845720
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Benzene 4.4612562636
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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