AutismKB 2.0

Annotation Detail for PRLH


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Basic Information Top
Gene Symbol:PRLH ( PRH,PRRP )
Gene Full Name: prolactin releasing hormone
Band: 2q37.3
Quick LinksEntrez ID:51052; OMIM: 602663; Uniprot ID:PRRP_HUMAN; ENSEMBL ID: ENSG00000071677; HGNC ID: 17945
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500405Peptide ligand-binding receptors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PRLH proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRLH mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of PRLH mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol affects the reaction [PRLH protein affects the expression of FOS protein]affects expression|affects reaction 15862908
D005419 Flavonoids Flavonoids results in decreased expression of PRLH mRNAdecreases expression 18035473
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000686 Amyloidosis Diethylstilbestrol 4.9215469931
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.5917129689 15324884
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.3412907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.3416924424 15948411
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003456 Cryptorchidism Diethylstilbestrol 5.0016002989 12952375
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.2316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6815700306 16804899
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8516513791 15751030 16534752 16002989 16611131
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.4916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006965 Hyperplasia Diethylstilbestrol 4.9212960047 14722030
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007021 Hypospadias Diethylstilbestrol 5.0616002989
MESH:D007246 Infertility Diethylstilbestrol 4.7915036965
MESH:D007249 Inflammation Flavonoids 2.8017296493
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.4815003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.5417184923
MESH:D008113 Liver Neoplasms Aflatoxin B1 5.1518177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Diethylstilbestrol 5.1515890375 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.948603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.7215700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.1316002989
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009369 Neoplasms Diethylstilbestrol 2.9115313581
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.5711399458
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.7814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.1615687265 16977796
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.6517184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5115046698 17136230 15846301
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D013088 Spermatocele Diethylstilbestrol 5.3216709447 16002989
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8816712894 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3816175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.7814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.5115809267 16690809
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.9216002989 16513791
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134927756
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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