AutismKB 2.0

Annotation Detail for LAP3


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Basic Information Top
Gene Symbol:LAP3 ( LAP,LAPEP,PEPS )
Gene Full Name: leucine aminopeptidase 3
Band: 4p15.32
Quick LinksEntrez ID:51056; OMIM: 170250; Uniprot ID:AMPL_HUMAN; ENSEMBL ID: ENSG00000002549; HGNC ID: 18449
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
No data
No data
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LAP3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LAP3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of LAP3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of LAP3 proteinincreases expression 16687475
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LAP3 proteindecreases expression 19364129
C032036 bromobenzene bromobenzene results in decreased expression of LAP3 mRNAdecreases expression 15056800
C006253 pirinixic acid pirinixic acid results in decreased expression of LAP3 mRNAdecreases expression 18445702
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.189612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9619483382
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.853084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8515553829 14691202 15073043 16217749 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.6018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.6014725611 10915739 16781746 16227642 10663392 16109766 11743745 12705907 18713872 16081117 11739529 19739265 12540782 11287661 12594235 14986274 17562736 12958197 12392966 17906064 19164858 17522070 12153990 18071297 19420014 15968718 19923254 19085960 2444490 11834606 14550746 11421492 10774834 15619225 19416960 16177239 19370779 11529661 16485898 11461765 16393943
MESH:D056486 Drug-Induced Liver Injury bromobenzene 9.6012628495 10092053
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Zidovudine 4.2115040536
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 14.9115073043
MESH:D005234 Fatty Liver pirinixic acid 14.9120131406 19236843
MESH:D005234 Fatty Liver Zidovudine 14.9118299183
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006402 Hematologic Diseases Zidovudine 5.0212579204
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 16221962 19772884 18467677
MESH:D015658 HIV Infections Zidovudine 3.6211698656 17358032 20032539 11141242 11363243
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9116705839
MESH:D007680 Kidney Neoplasms Zidovudine 13.9112579204
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.8017077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.8020370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 17050201 19850784 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.389834237 15622746 17712046 16330433 12712474 16331271 17649720 17869043 19642359 12018890 16823087 17217047 19035177 15336539 11468182 15748426 16112521 11161223 15213294 12679006 17107899 19225113 16891316 16966277 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 12969438 16611625 19784758 16610002 11587558 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.937678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9314682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.9320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.502876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5020377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.8211798837 19825857
MESH:D008175 Lung Neoplasms Zidovudine 2.8218800350
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.2817358032
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919417148 14977855 19549372 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7617007042
MESH:D013274 Stomach Neoplasms Zidovudine 2.7617696246
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8520435036 12845720 11780464 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1212579204
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:00480 Glutathione metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02386 - Leucine Phosphonic Acid Molecule: Leucine Aminopeptidase
DB03684 - 2-Methyl-2,4-Pentanediol
DB07448 - (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid
DB08766 - L-PROLINE, 1-[(2S)-3-MERCAPTO-2-METHYL-1-OXOPROPYL]-4-(PHENYLTHIO)-, 4S
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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