AutismKB 2.0

Annotation Detail for PCK2


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Basic Information Top
Gene Symbol:PCK2 ( PEPCK,PEPCK-M,PEPCK2 )
Gene Full Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Band: 14q11.2-q12
Quick LinksEntrez ID:5106; OMIM: 261650; Uniprot ID:PCKGM_HUMAN; ENSEMBL ID: ENSG00000100889; HGNC ID: 8725
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa00010Glycolysis / Gluconeogenesis
hsa03320PPAR signaling pathway
hsa00020Citrate cycle (TCA cycle)
hsa04964Proximal tubule bicarbonate reclamation
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
Pathway IDPathway Name
200077Glucocorticoid receptor regulatory network
No data
Pathway IDPathway Name
500678Gluconeogenesis
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
PEPCK deficiency, mitochondrial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PCK2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PCK2 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PCK2 proteindecreases expression 19364129
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PCK2 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PCK2 mRNAaffects expression 17484886
D002995 Clofibric Acid Clofibric Acid affects the expression of PCK2 mRNAaffects expression 17602206
D003345 Corticosterone Corticosterone results in decreased expression of PCK2 mRNAdecreases expression 15755911
C030123 coumarin coumarin results in increased expression of PCK2 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine affects the expression of PCK2 mRNAaffects expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNAaffects cotreatment|increases expression 15784690
D004958 Estradiol Estradiol results in increased expression of PCK2 mRNAincreases expression 15757668
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PCK2 mRNAaffects expression 17555576
D011345 Fenofibrate Fenofibrate results in increased expression of PCK2 mRNAincreases expression 16569247
D019833 Genistein Genistein results in increased expression of PCK2 mRNAincreases expression 15757668
D008345 Manganese Manganese binds to PCK2 proteinaffects binding 16819824
D008345 Manganese Manganese binds to [PCK2 protein binds to Phosphoenolpyruvate]affects binding 16819824
C030110 oxaliplatin oxaliplatin results in decreased expression of PCK2 mRNAdecreases expression 17762391
D020351 Oxaloacetic Acids PCK2 protein results in decreased carboxylation of Oxaloacetic Acidsdecreases carboxylation 16819824
D010728 Phosphoenolpyruvate Manganese binds to [PCK2 protein binds to Phosphoenolpyruvate]affects binding 16819824
D010728 Phosphoenolpyruvate PCK2 protein results in increased chemical synthesis of Phosphoenolpyruvateincreases chemical synthesis 16819824
D012645 Selenomethionine Selenomethionine affects the expression of PCK2 mRNAaffects expression 17222674
D013467 Sulindac Sulindac results in increased expression of PCK2 mRNAincreases expression 11906190
D013629 Tamoxifen Tamoxifen affects the expression of PCK2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PCK2 mRNAdecreases expression 20106945
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PCK2 mRNAaffects expression 21346803
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNAaffects cotreatment|increases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.4414745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.4414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0015322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.007525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.659612607
MESH:D058186 Acute Kidney Injury Sulindac 4.167897758
MESH:D000230 Adenocarcinoma arsenic trioxide 16.5619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.5620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 16.5611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.5614692618
MESH:D000230 Adenocarcinoma Genistein 16.5611473722
MESH:D000230 Adenocarcinoma Sulindac 16.5611910360
MESH:D000236 Adenoma Benzo(a)pyrene 6.656695378
MESH:D000236 Adenoma Sulindac 6.6510223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2116835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4519003578 16460482 17611924 12394442 15623613 11874996 11535846
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000756 Anemia, Sideroblastic Manganese 4.7116910769
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.4416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001913 Bowen's Disease Sulindac 5.1811207687
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8820146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.8814630087 17289903 18497071 19861407 16675129 17261762 17018787 12948864
MESH:D001943 Breast Neoplasms Genistein 2.8817200150 16541309 16873071
MESH:D001943 Breast Neoplasms Sulindac 2.8816642371
MESH:D001943 Breast Neoplasms Tamoxifen 2.8819288272 19221464 20005174 18815881 19103187 11161223 19487384 17893378 21152245 20065188 17261762 20544844 19200415 18855134 19410462 16818667 15565566 20135344 16273361 19289846 20390343 19084267 15668708 18351453 19244106 17242785 17440819 16202921 19059307 19066611 20859285 19189210 18984771 19142967 16873071 18821012 17049068 19155303 21138602 19189212 19115204 18425577 18629630 19011961 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6110355542 16227642 16192424 15673190 3786805 16011737 16050911 15700767 18705752 15721981 16097048 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.663084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.6621507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.6611135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6618788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.6616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.6616924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6616924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.1916332659
MESH:D002386 Cataract Acetaminophen 7.1810977129
MESH:D002386 Cataract Trinitrotoluene 7.1815817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 7.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3616919318 11677210 15861022 17681005 17110522 17333356 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0316354765 8697196 15340226 15668235 12621046
MESH:D003110 Colonic Neoplasms Genistein 5.9017182828
MESH:D003110 Colonic Neoplasms oxaliplatin 5.9016004971 16510598 16024531
MESH:D003110 Colonic Neoplasms Sulindac 5.9012902858 12458338
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5920501625
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.5917255274 17401013 17594712 17695437 18448328 18509181
MESH:D015179 Colorectal Neoplasms Sulindac 3.5910666051 11197048 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7917141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.7915095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4220055451 15322242 10048152
MESH:D003490 Cyanosis Trinitrotoluene 4.7518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 6.9919647726
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9917107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3619279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.0112861449 17621415
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5612594235 11834606 10663392 17906064 16485898 12958197 11743745 17522070 11461765 16177239 18713872 16227642 12392966 15968718 16393943 16081117 19416960 16109766 12153990 15619225 2444490 10915739 12540782 19085960 19923254 11421492 11739529 11287661 18071297 19420014 14725611 10774834 14550746 19739265 12705907 14986274 11529661 19370779 16781746 19164858 17562736
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.5616227642 6623471 9327722 19336974 17522070 7440962 10092053 7179309 4309450 3732212 2869522 15968718 21278145 19085960 10915739 3786805 15027814 15998439 16177239 7120509 6884620 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5620420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 8.5618551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Lamivudine 13.1415040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.1411462148
MESH:D004362 Drug Toxicity Zidovudine 13.1415040536
MESH:D050171 Dyslipidemias Fenofibrate 4.3016707586
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.4216402032
MESH:D016889 Endometrial Neoplasms Estradiol 16.9211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 16.9216569247
MESH:D016889 Endometrial Neoplasms Genistein 16.9211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.9216202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Sulindac 8.6915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.699294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.0912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0916530937
MESH:D004938 Esophageal Neoplasms Sulindac 7.0912235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver arsenic trioxide 28.6915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.6912795759 17595544 19224547 16239168 61145 16045604 12631006 15959796
MESH:D005234 Fatty Liver Cyclosporine 28.6919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.6915345470
MESH:D005234 Fatty Liver Tamoxifen 28.6919224547 14986274
MESH:D005234 Fatty Liver Zidovudine 28.6918299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.3814745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.3814745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 11.0619069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.0619069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.7218705752
MESH:D005355 Fibrosis Cyclosporine 13.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.7220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8411910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Genistein 7.1816598420
MESH:D005909 Glioblastoma Manganese 7.1817043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1511294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.5512579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006509 Hepatitis B Lamivudine 4.9417703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.9415274664 16476009 12044531 15631357 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1516120746 15340226 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 8.1515817613
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D015658 HIV Infections Lamivudine 6.769296927 17530837 11141242 20032539
MESH:D015658 HIV Infections Zidovudine 6.7611141242 11363243 17358032 11698656 20032539
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.5916870215
MESH:D006930 Hyperalgesia oxaliplatin 7.5917418472
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007003 Hypoglycemia marker/mechanism
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5217937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.5212150543
MESH:D007249 Inflammation Sulindac 7.883291741
MESH:D007249 Inflammation Tamoxifen 7.8819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.8616627594 16393666
MESH:D007414 Intestinal Neoplasms Sulindac 4.4812584176 12628509 12663524 10213222 10223192 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.8311245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.418314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.4115618244
MESH:D007680 Kidney Neoplasms Cyclosporine 16.6312371664
MESH:D007680 Kidney Neoplasms Estradiol 16.6315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.6318625569
MESH:D007680 Kidney Neoplasms Zidovudine 16.6312579204
MESH:D007938 Leukemia arsenic trioxide 6.1515070760
MESH:D007938 Leukemia Genistein 6.1517468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.3212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 9.3220370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1116467208 17050201 16968895 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1012712474 11161223 19035177 19075265 17712046 17217047 19642359 12679006 16891316 15336539 17649720 16330433 11468182 17869043 16823087 15748426 15213294 19225113 17107899 16331271 9834237 16966277 16112521 12018890 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1916882451
MESH:D008064 Lipidoses Tamoxifen 3.0315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7116239168 17157831 17174718 16943688 21278145 11408273 17334410 16221502 11903743
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1212468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4618395095 15730626 12586293 12546737 18156304 14620537 20821823 16248980 18166357 12389079 18263696 18395914 15893842 14512876 18481824 12632514 18418968 15673190 12632512 15370692 17869086 17698563 11481614 17761835 14724832 15818738 17900296 12898905 15959796 17525996 15052691 18277467 18705752 12666154 12741479 12445421 12649538 15876570 18317297 18472332 17944888 14716496 17631135 17721639 14716833 10355542 18429990 12667390 16027843 16015684 16011737 18412020 12609069 14748882 15931870 17714472 17565644 18210741 18420326 18279442 12958196 13678700 15996030 18205269 17922224 18376398 17766677 17557913 16638106 18251166 16033810 17823541 15123356 17805973 16116963 17708605 18472094 17640975 17481882 15338365 16097048 18006644 16136751 18339082 18054572 12445418 18187930 15057751 17976157 15925388 16192424 15650968 15362042
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 8.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4617823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4612878042
MESH:D008107 Liver Diseases Acetaminophen 6.3312587719 19784758 16611625 19014921 19460945 12969438 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3316964402 16246199 15720792 17285989 15830285
MESH:D008107 Liver Diseases Sulindac 6.3316867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.8415890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 24.8414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.8421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.8419294768
MESH:D008113 Liver Neoplasms Clofibric Acid 24.8417602206
MESH:D008113 Liver Neoplasms Fenofibrate 24.8418978307
MESH:D008113 Liver Neoplasms Tamoxifen 24.8416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.8416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.538603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.5320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.5315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 17.5318775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2215213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.3814755239
MESH:D008175 Lung Neoplasms arsenic trioxide 10.3811798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.386695378 20464547 17053015 18816296 20135361 18569708 20869020 18520028 20064080
MESH:D008175 Lung Neoplasms Sulindac 10.3815713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 10.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3811884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 10.3818800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 13.4212807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.4211408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.4214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.4216827153 19196723 11731420 19196722 14580682
MESH:D020149 Manganese Poisoning Estradiol 21.3919453300
MESH:D020149 Manganese Poisoning Manganese 21.3919453300 16551646 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 21.3919453300
MESH:D008545 Melanoma Sulindac 3.5116642371
MESH:D008545 Melanoma Tamoxifen 3.5112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6717358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D009069 Movement Disorders Manganese 4.8516551646
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9814977855 11468182 15949261 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0516882451 16105982
MESH:D009203 Myocardial Infarction Genistein 2.7917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.0817141266
MESH:D009336 Necrosis Trinitrotoluene 4.5918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7916624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.0911141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.1416551646
MESH:D009421 Nervous System Malformations Estradiol 15.4016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.4016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.4014600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Sulindac 8.0617266991 16850258
MESH:D009784 Occupational Diseases Trinitrotoluene 4.1914694615 12819281 17852074
MESH:D010024 Osteoporosis Genistein 3.1519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9216169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5916624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 7.5919401270
MESH:D010051 Ovarian Neoplasms Genistein 7.5919005980
MESH:D010146 Pain Acetaminophen 6.4516870215
MESH:D010146 Pain Sulindac 6.453291741
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4115580305
MESH:D010190 Pancreatic Neoplasms Sulindac 5.4116820089 11504793
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D010300 Parkinson Disease Manganese 3.3111181820
MESH:D020734 Parkinsonian Disorders Manganese 4.3216140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8616740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8615378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.369296927
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7916646077
MESH:D012640 Seizures Trinitrotoluene 3.3318551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.2119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.0315817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.342093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 3.3417696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9619014326
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.9112845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.9117572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.1214692618
MESH:D014594 Uterine Neoplasms Sulindac 9.1218645019
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5912579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D014689 Venous Insufficiency coumarin 5.6012708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:04910 Insulin signaling pathway
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:03320 PPAR signaling pathway
KEGG:04964 Proximal tubule bicarbonate reclamation
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33070
    • No data
    No data
    Releated drug ID Related drug Name
    PA448625biotin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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