AutismKB 2.0

Annotation Detail for RPS27L


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Basic Information Top
Gene Symbol:RPS27L ( - )
Gene Full Name: ribosomal protein S27-like
Band: 15q22.2
Quick LinksEntrez ID:51065; OMIM: 612055; Uniprot ID:RS27L_HUMAN; ENSEMBL ID: ENSG00000185088; HGNC ID: 18476
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of RPS27L mRNAincreases expression 15890375
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPS27L mRNAdecreases expression 18648102
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS27L mRNAincreases expression 15890375
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of RPS27L mRNAincreases expression 15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS27L mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RPS27L mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RPS27L mRNAincreases expression 19150397
C006780 bisphenol A bisphenol A results in increased expression of RPS27L mRNAincreases expression 20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of RPS27L mRNAincreases expression 15336504
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RPS27L mRNAaffects cotreatment|increases expression 19684285
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RPS27L mRNAincreases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RPS27L mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RPS27L mRNAincreases expression 15890375
D004317 Doxorubicin Doxorubicin results in increased expression of RPS27L proteinincreases expression 18056458
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RPS27L mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RPS27L mRNAincreases expression 17942748
D005047 Etoposide Etoposide results in increased expression of RPS27L proteinincreases expression 18056458
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of RPS27L mRNAincreases expression 17317680
D005472 Fluorouracil Fluorouracil results in decreased expression of RPS27L proteindecreases expression 18056458
D005472 Fluorouracil Fluorouracil results in increased expression of RPS27L mRNAincreases expression 16557594
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of RPS27L mRNA]affects reaction|increases expression 15016801
D008701 Methapyrilene Methapyrilene results in increased expression of RPS27L mRNAincreases expression 15890375
D015741 Metribolone Metribolone affects the splicing of RPS27L mRNAaffects splicing 17010196
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of RPS27L mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in increased expression of RPS27L mRNAincreases expression 15890375
D012643 Selenium Selenium results in decreased expression of RPS27L mRNAdecreases expression 19244175
C009277 sodium arsenate sodium arsenate results in increased expression of RPS27L mRNAincreases expression 16882884
D013629 Tamoxifen Tamoxifen affects the expression of RPS27L mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RPS27L mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPS27L mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPS27L mRNAincreases expression 17942748
D014635 Valproic Acid Valproic Acid results in increased expression of RPS27L mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.558875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.9220464547 20127859
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.9216033868
MESH:D000230 Adenocarcinoma Doxorubicin 12.9217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9214692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.9217638652
MESH:D000236 Adenoma 2-Acetylaminofluorene 24.5710737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 24.573712494
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 24.5716176798
MESH:D000236 Adenoma Benzo(a)pyrene 24.576695378
MESH:D000236 Adenoma Diethylnitrosamine 24.576695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 24.5719555203
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.786705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.9519061943 17620307 19052882 17162532 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.9516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9516835633
MESH:D000419 Albuminuria Doxorubicin 4.3221441931
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2615469931
MESH:D000740 Anemia Fluorouracil 8.0216511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0211748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.3917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0318177632 15238991 18558336 17157402 18985861 20603192 18775368 17507914 16609825 18316065 19232924 18396377 17688650 19460635 18940202
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.9620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.3914601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.3914601052
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 6.7720146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.7720146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 6.7717123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.7717474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.7715324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 6.7718234424 17983394 19526202 17426702 17369602 16595493 18628466 16935488 18695136 15668708 15939500 16826403 15136595 15993339 16096432 15994142 16264153 16322301 15634643 16115903 15567936 15692762 11325840 18382427
MESH:D001943 Breast Neoplasms Etoposide 6.7716322251
MESH:D001943 Breast Neoplasms Fluorouracil 6.7716110121 18608205 19217205 16557594 18357371 16595493 15136595
MESH:D001943 Breast Neoplasms Tamoxifen 6.7719155303 20859285 19189210 19084267 19189212 17242785 16273361 20065188 20135344 20005174 16202921 19115204 11161223 20390343 19142967 18984771 17893378 21152245 18629630 19487384 19059307 19289846 18855134 17440819 18351453 18997820 19221464 19200415 19011961 18821012 19244106 19410462 18815881 21138602 19066611 17261762 19288272 16818667 19103187 18425577 20544844 15565566 15668708 17049068 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7720435547
MESH:D002276 Carcinoid Tumor Doxorubicin 11.5816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.5816051944
MESH:D002277 Carcinoma Dimethylnitrosamine 12.9619555203
MESH:D002277 Carcinoma Fluorouracil 12.9617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 16.2610737359 3084413 6705139 3581430 17761372
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.2612619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.2618494052 19701751 16935385 11831363 20214788 16807293 16878318 18785209 19208518 20935162 19107877 16698587 18691550 19335982 18665156 19539802 16288022 20524982 19418558 20007298 17162532 16540662 17978847 18210153 16681979 19394651 17761372 18978308 17055752 16830150 20512989 19052882 16328049 20084675 16502159 21159647 19383236 16779866 18056438 17428255 19171122 3581430 18788625 19822196 20101231 19519916 18971187 3084413 20432363 10672840 20727157 20514400 17138121 19919837 16569478 18506893 18393292 10737359 17173139
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.2616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.2616234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.2617971768 16332177 16799960 17088986 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.2616924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.167296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.161485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.1618695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2720419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 10.2716033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.276189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.2716757204 18986760 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2416120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3816269455 17007740 16455267 16364871 17928571 16612575 15505089 17131338 16242529 17329180 17382496 17308081 17974986 16651473 17924179 15476868 15811867 16731534 17351982 17519947 16278810 16952015 15792986 16109756 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8717334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.287505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2820889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.2817174075 7505956 2727394 21159647
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.4119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4117681005 17333356 16919318 16105132 15861022 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 12.4119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.018697196 15340226 16354765 12621046 15668235
MESH:D003092 Colitis Selenium 3.5617936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2016510598 17287894 17725105 17018589 15001691 17016597 18772588 16340194 17169374 17172411
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.5918259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5917594712 16524972 17016601 17401013 14970324 17695437 15289873 20501625 18949393 18509181 16331619 16303861 18288408 15148649 17094418 18383874 18448328 16391804 17255274 16282729 17454858 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.7410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7420055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7417688650 8888407 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3412952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.5616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5912868966 11906362 8156756 11298694 18759878 8970840 14531868 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.282952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2919279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 21.0316192314 9022650 7440962 18648102 1440618 6679447 18692083 8291058 9653073 11289319 6482804 9328219 18289764
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 21.0319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 21.038172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 21.0317416283
MESH:D056486 Drug-Induced Liver Injury Selenium 21.0315131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 21.0318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.0320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 21.0319641884 1733752
MESH:D004362 Drug Toxicity Doxorubicin 7.5618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5611462148
MESH:D004421 Dystonia Valproic Acid 3.841851702
MESH:D004487 Edema pirinixic acid 5.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2219031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.6816804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.6817359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.6820544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.693922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.406254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.077750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.843659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 13.183581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.1820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 13.1816530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 13.1817016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 13.1816337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 22.4620387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.4615345470
MESH:D005234 Fatty Liver pirinixic acid 22.4620131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 22.4619224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 22.4614986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.7616611131 16002989 16534752 15751030 16513791
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.7616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.918888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.6819069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.6819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7320067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7216452187
MESH:D005909 Glioblastoma Doxorubicin 3.2017150277
MESH:D005910 Glioma Fluorouracil 2.7816145905
MESH:D018149 Glucose Intolerance sodium arsenate 4.8719446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.4115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.4115102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0510048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3312587719 18006777 16879835 17888722 16330681 16244371 14766674 16144979 16707910 16495754 16244372 18674790 17875725
MESH:D006333 Heart Failure Doxorubicin 11.0017481944
MESH:D006333 Heart Failure pirinixic acid 11.0020558911
MESH:D006333 Heart Failure Selenium 11.0017162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.086705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 8.736705139
MESH:D006394 Hemangiosarcoma Doxorubicin 8.7315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006529 Hepatomegaly pirinixic acid 7.5216221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5215340226 12621046 16120746
MESH:D006561 Herpes Simplex Etoposide 4.3310809021
MESH:D006689 Hodgkin Disease Doxorubicin 7.1117606976 15147373 18501091
MESH:D006689 Hodgkin Disease Etoposide 7.1115147373 17606976 18180244 16200630 16135485
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8115340226 18606429 8697196 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.0915034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.0912960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 10.4916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4916569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.1415036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3417937319
MESH:D007249 Inflammation Diethylnitrosamine 7.5818785209
MESH:D007249 Inflammation Tamoxifen 7.5819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5812878042 12200463
MESH:D007251 Influenza, Human Selenium 3.9716624496
MESH:D007333 Insulin Resistance bisphenol A 6.8216393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.798074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007674 Kidney Diseases Doxorubicin 2.9315699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.3016707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.3016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.286582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.2814681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Fluorouracil 16.2816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 16.2818625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8417184923
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1116294345 17596541
MESH:D008064 Lipidoses Tamoxifen 2.9917567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7020032147 18522880 18407596 18665156 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.069327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.4214726149 15492853 18567088 15369754 15723089 17348192 15793283 17198567 16603200 18672772 17724770 18371158 17534399 14709902 18237412 15366600 16570917 17666798 15161499 12925901 18629640 15081153 18210741 18239293 15086199 15099470 17203207 14643895 17201889 17719030 15798949 16169303 14568256 12918455 15591649 15763062 15383259 17881167 15571005 15864749 15744066 16627068 16009107 17432682 15504291 16042886 18637143 15842777 15138612 15733078 18095165 16544323 15942678 17036385 15298665 15067225 17640959 15339415 17196135 18364076 16270385 17465448 15577212 15479170 14659978
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.4216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0517034775
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.2117457977
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 50.3718001218 16273603 10672840 11376686 14678523 10737359
MESH:D008113 Liver Neoplasms 2-nitrofluorene 50.3715890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 50.3715890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 50.3718177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 50.3720195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 50.3721071580 19499222 9163691 19090486 19256749 19294768 20583210 12771043 18754104 19812893 10737359 19254457 19833225 15175105 20405173 18978307 19690152 19638242 19426721 20137499 18644402 19551842 20492335 18648771 21167192 20118626 16942905 18977376 19427195 21278145 19073162 20101389 2862719 12112319 19255062 15885732 21047994 2422723 19642983 20501860 19996281 20434301 19850985 20452335
MESH:D008113 Liver Neoplasms Diethylstilbestrol 50.3715890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 50.373113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 50.3715113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms Methapyrilene 50.3715890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 50.3720101389 19690152 15890375 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 50.3716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 50.3716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 50.3716984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 26.111399818 534488 6150874
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 26.116587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.118603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.1118093689 18079962 19519916 18544905 18282651 21159647 18308698 16267830 18253720 19004024 19126423 19009564 3124819 19539802 18164116 16842330 17942915 2563599 17174075 18775883 17854601 9362446
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 26.1115603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 26.1117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.1112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 17.3311376686
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 17.3319931552 15172992 18508827 12438228 14755239 9255578 18813816 16061637 15893417 17139156 16401635
MESH:D008175 Lung Neoplasms Aflatoxin B1 17.3314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 17.3318816296 20464547 20135361 17053015 6695378 18520028 18569708 20064080 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 17.3320970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 17.3316061637 11884234 19555203
MESH:D008175 Lung Neoplasms Doxorubicin 17.3317418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 17.3315246190
MESH:D008175 Lung Neoplasms Tamoxifen 17.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 17.3319555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9215166399
MESH:D008223 Lymphoma Diethylstilbestrol 11.7715700306
MESH:D008223 Lymphoma Doxorubicin 11.7716098063
MESH:D008223 Lymphoma Etoposide 11.7712854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2816002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.1815458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.1815318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.1811731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.3219453300
MESH:D008545 Melanoma Doxorubicin 3.2816827129
MESH:D008545 Melanoma Tamoxifen 3.2812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008654 Mesothelioma Doxorubicin 5.9917638057
MESH:D008654 Mesothelioma Selenium 5.9915107826
MESH:D008881 Migraine Disorders Valproic Acid 3.0318765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.9516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9518986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.5617415656
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 10.0018186108
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 10.008888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0317596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.3919429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.3919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7716411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.833581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.839029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 12.8318259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9311141357
MESH:D009369 Neoplasms Diethylstilbestrol 10.9315313581
MESH:D009369 Neoplasms Fluorouracil 10.9318239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 10.9317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719189210 19200415 19196722
MESH:D009401 Nephrosis Doxorubicin 4.5416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8116889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 15.1516427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.1511399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.406679447
MESH:D009436 Neural Tube Defects sodium arsenate 11.4011749123 10525206 18186108 19446573
MESH:D009436 Neural Tube Defects Valproic Acid 11.408888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 3.1515555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2916436463
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.226482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.7412384795
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7416540662
MESH:D010190 Pancreatic Neoplasms Etoposide 11.7419003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.7416500647 16929163 19003803 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4515687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.362563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.3610548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 21.3617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.3611118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 21.3620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0715046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0715897917 16888761 16729912 16868541 18437689 15749863
MESH:D011471 Prostatic Neoplasms Etoposide 2.0717172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0719082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.3111422049 12752131
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8216160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.0017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9619155313
MESH:D012509 Sarcoma Doxorubicin 3.7915675481 16767912 17203757 17710206 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8216326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 9.8214601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Valproic Acid 2.5916876388 11044598 17978042 15475178 14763951 1511512 3137016 11738929
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.6810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 12.6815692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.688532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3415625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 18.7916002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 18.7916709447
MESH:D013088 Spermatocele Tamoxifen 18.7916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8119457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6119490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0412587719
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.552093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5518456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.5516033868
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5515786421 18567086 16951190 18396642 17172411 17522103 19084572 19015929 17498489 16424979
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.006582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.007505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.0017909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7916280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 18.7215289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.728074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.7217053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.7216712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.7217653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.728653321 17572228 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.9216175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.9216803524
MESH:D014591 Uterine Diseases bisphenol A 13.0414652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.0414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.7515809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7514692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2116513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0017678736 17334414 17638931 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
Pathway ID Pathway Name
KEGG:03010 Ribosome
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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