AutismKB 2.0

Annotation Detail for NMD3


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Basic Information Top
Gene Symbol:NMD3 ( FLJ21053 )
Gene Full Name: NMD3 homolog (S. cerevisiae)
Band: 3q26.1
Quick LinksEntrez ID:51068; OMIM: 611021; Uniprot ID:NMD3_HUMAN; ENSEMBL ID: ENSG00000169251; HGNC ID: 24250
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NMD3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NMD3 mRNAaffects expression 21346803
D001151 Arsenic Arsenic affects the expression of NMD3 mRNAaffects expression 18414638
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NMD3 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NMD3 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9416251483 12569548 18414634 16835338
MESH:D050197 Atherosclerosis Arsenic 3.4419371607 12928151
MESH:D001321 Autistic Disorder Valproic Acid 1.9818316065 18940202 17507914 17688650 20603192 18558336 18985861 18396377 19460635 19232924 15238991 16609825 18177632 18775368 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.2317594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8816705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8816507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7715504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6418022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.006135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.5618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.5618551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.7519641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 2.989931084 16076760 11953799
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1116612254
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007642 Keratosis Arsenic 5.5316930632 12749816
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.3916705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 5.097678174
MESH:D008113 Liver Neoplasms Arsenic 5.0916368122
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.742876784 6135515 2876786
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms Arsenic 2.2119168569 17976673 17306315
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D017202 Myocardial Ischemia Arsenic 4.2715371236
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.2118551238 7678174
MESH:D009436 Neural Tube Defects Arsenic 8.1816620997
MESH:D009436 Neural Tube Defects Valproic Acid 8.1816359493 8888407
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.0612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.0616049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.8317306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5316905509 6392382 15371236
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 11.2018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.2018551238
MESH:D012640 Seizures Valproic Acid 11.2014763951 11738929 17978042 16876388 3137016 15475178 11044598 1511512
MESH:D012871 Skin Diseases Arsenic 2.8217548696 6392382 18709164 19834688 16353154 16759981 17453740 16702368 17938729 17050553 15952646
MESH:D012878 Skin Neoplasms Arsenic 3.1517976673 16251483 17029826 19538983 17050553 15504454
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 9.0311144890 19429237 19322015 18640142 17306315 17976673 15987713
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.8610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.8610091137
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
KEGG:03013 RNA transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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