AutismKB 2.0

Annotation Detail for MRPL4


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Basic Information Top
Gene Symbol:MRPL4 ( CGI-28,L4mt,MGC16367,MGC2681 )
Gene Full Name: mitochondrial ribosomal protein L4
Band: 19p13.2
Quick LinksEntrez ID:51073; OMIM: 611823; Uniprot ID:RM04_HUMAN; ENSEMBL ID: ENSG00000105364; HGNC ID: 14276
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of MRPL4 mRNAaffects expression 21346803
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MRPL4 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MRPL4 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MRPL4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRPL4 mRNAaffects cotreatment|increases expression 17942748
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of MRPL4 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of MRPL4 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRPL4 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of MRPL4 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of MRPL4 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.837525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8314514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4118056438 17620307 17162532 19052882 16434500 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8716878318 16681979 20214788 17428255 10672840 11831363 20514400 19383236 17138121 19107877 17055752 19418558 16540662 19519916 17978847 3581430 19539802 20524982 16328049 18691550 18393292 17761372 18210153 19394651 19052882 20432363 16830150 16779866 19701751 18978308 16935385 19822196 16502159 19335982 19919837 20512989 19171122 10737359 20727157 20935162 16288022 20084675 18788625 18494052 17173139 18971187 3084413 16698587 19208518 18785209 16569478 17162532 18506893 21159647 20101231 18665156 16807293 18056438 20007298
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7814694615
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.042727394 17174075 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.1719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.1716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717333356 16919318 16105132 17681005 11677210 17110522 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15668235 15340226 16354765 8697196
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 10.0315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.0317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.5921346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.5919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 9.5915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0016080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 15340226 16959395 8697196 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3312878042 12200463
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Vitamin E 2.9512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618407596 20032147 18665156 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9812771043 10737359 20137499 19427195 18977376 9163691 18644402 15885732 18648771 20492335 19294768 19642983 19426721 20405173 20583210 20452335 12112319 19090486 19255062 21047994 20101389 19551842 18754104 2422723 19254457 18978307 19996281 21071580 15175105 20434301 19690152 19073162 21278145 20501860 19499222 2862719 19638242 20118626 19833225 19812893 19850985 19256749 16942905 21167192
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3016842330 19519916 18079962 19009564 21159647 18282651 17942915 16267830 2563599 19539802 18775883 18164116 19004024 18093689 18308698 18544905 9362446 17174075 17854601 18253720 19126423 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3012151625
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5321163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.3614694615
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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