AutismKB 2.0

Annotation Detail for PCM1


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Basic Information Top
Gene Symbol:PCM1 ( PTC4 )
Gene Full Name: pericentriolar material 1
Band: 8p22
Quick LinksEntrez ID:5108; OMIM: 600299; Uniprot ID:PCM1_HUMAN; ENSEMBL ID: ENSG00000078674; HGNC ID: 8727
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
2122Protein-energy malnutrition
Desease Name
PSYCH
schizophrenia
No data
Desease Name
Thyroid carcinoma, papillary
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PCM1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PCM1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PCM1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PCM1 mRNAaffects expression 17562736
D003010 Clorgyline Clorgyline results in increased expression of PCM1 mRNAincreases expression 19691856
D003024 Clozapine Clozapine results in decreased expression of PCM1 mRNAdecreases expression 19048012
D000431 Ethanol Ethanol results in decreased expression of PCM1 mRNAdecreases expression 15353170
D005419 Flavonoids Flavonoids results in decreased expression of PCM1 mRNAdecreases expression 18035473
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of PCM1 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of PCM1 mRNAincreases expression 18445702
D012643 Selenium Selenium results in decreased expression of PCM1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of PCM1 mRNAaffects expression 18691609
D014810 Vitamin E Vitamin E results in decreased expression of PCM1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.8617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8611752688 14514962 15322242
MESH:D000138 Acidosis Ethanol 4.6111192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000380 Agranulocytosis Clozapine 5.1614617031 12649775 16160616
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4515451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D000853 Anophthalmos Ethanol 4.9215513904
MESH:D001008 Anxiety Disorders Ethanol 4.0711141031
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002056 Burns Ethanol 4.7616374292
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.007296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.003084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 9.0018788625 15289165 15763234
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly Ethanol 6.9919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.846135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.847505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.0419486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.0419176532
MESH:D002971 Cleft Lip Ethanol 3.6215513904
MESH:D002972 Cleft Palate Ethanol 6.0615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0612621046 8697196 15668235 16354765 15340226
MESH:D003072 Cognition Disorders Clozapine 5.0717123785
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6720423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8815451039 15451040 19302082 10194807 15513904 11198716 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8819769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9011906362 8156756 14531868 12868966 11298694 18759878 8970840 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5716402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5717107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6915331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.0718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.0718289764 9653073 9022650 1440618 8291058 11289319 18692083 6679447 6482804 7440962 16192314 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.0719420014 16177239 12540782 15968718 12594235 12705907 16227642 18071297 12153990 16109766 19923254 14725611 11739529 17906064 11743745 10915739 10774834 11421492 11834606 16081117 15619225 12958197 14986274 19416960 14550746 10663392 16485898 11461765 2444490 19739265 17562736 11287661 11529661 17522070 19370779 18713872 16393943 16781746 19164858 19085960 12392966
MESH:D056486 Drug-Induced Liver Injury Ethanol 19.0711566570
MESH:D056486 Drug-Induced Liver Injury Selenium 19.0715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.0720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Clozapine 4.2416402076
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.703581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.7016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethanol 8.1519236843 18620774 16409862
MESH:D005234 Fatty Liver pirinixic acid 8.1519236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4216946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 11.5816983495
MESH:D005756 Gastritis Ethanol 11.5815046732
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.0316870215
MESH:D006930 Hyperalgesia Ethanol 8.0318783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006948 Hyperkinesis Clozapine 5.0316046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007249 Inflammation Flavonoids 5.1317296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1312878042 12200463
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 10.3915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.8016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.8016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.806582329
MESH:D007859 Learning Disorders Ethanol 4.3115451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8717676605
MESH:D008064 Lipidoses Clozapine 4.0217567588
MESH:D008103 Liver Cirrhosis Ethanol 3.4115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2118295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.0318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0316169303
MESH:D008107 Liver Diseases Acetaminophen 1.6516610002 16611625 19460945 12969438 19014921 12587719 11587558 19784758
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7617347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.497678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.4916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.066135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.061399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0612151625
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 2.3311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008569 Memory Disorders Ethanol 4.2818411066 15451040
MESH:D001523 Mental Disorders Clozapine 4.0616856516
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.4819142101
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.747678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Clozapine 4.7618515891 19142110
MESH:D009765 Obesity pirinixic acid 4.7620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.5212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.5216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9912384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Clorgyline 3.6519691856
MESH:D011471 Prostatic Neoplasms Vitamin E 3.6515084515
MESH:D011618 Psychotic Disorders Clozapine 4.2415331141
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012559 Schizophrenia marker/mechanism 19048012
MESH:D012559 Schizophrenia Clozapine 2.7420521326 18806925 20168265 11151749 20452607 17123785 18855531 19369910 17667964 16141801 11763009 20521320 20580759 20107430 17726453
MESH:D012640 Seizures 2,4-dinitrotoluene 10.2018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.2018551238
MESH:D012640 Seizures Ethanol 10.209754883
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.6117189318 17918041 9562338 16755016 9211565 11906479
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.339754883
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.0615864552
OMIM:188550 THYROID CARCINOMA, PAPILLARY marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.953712494 6582329 1399818 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.458074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Clozapine 4.5416141801 20107430 20521320 17502770 16402076 20564506
MESH:D015431 Weight Loss Clozapine 5.1917933447
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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