AutismKB 2.0

Annotation Detail for SIDT2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SIDT2 ( DKFZp686L17253,FLJ90656 )
Gene Full Name: SID1 transmembrane family, member 2
Band: 11q23.3
Quick LinksEntrez ID:51092; OMIM: NA; Uniprot ID:SIDT2_HUMAN; ENSEMBL ID: ENSG00000149577; HGNC ID: 24272
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SIDT2 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of SIDT2 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of SIDT2 mRNAaffects expression 18414638
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SIDT2 mRNAincreases expression 20382639
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SIDT2 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of SIDT2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SIDT2 mRNAaffects cotreatment|affects expression 17602206
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SIDT2 mRNAaffects cotreatment|increases expression 17183730
D014212 Tretinoin Tretinoin results in increased expression of SIDT2 mRNAincreases expression 16249480
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SIDT2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of SIDT2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1417162532 19052882 18056438 19061943 17620307 16434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9116251483 16835338 18414634 12569548
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D050197 Atherosclerosis Arsenic 3.3412928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618316065 18940202 18558336 17688650 17507914 20603192 17157402 19460635 18985861 15238991 19232924 16609825 18396377 18177632 18775368
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6815504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7819335982 16328049 16779866 17138121 19052882 18971187 18785209 19171122 18393292 10737359 3581430 18978308 19107877 17055752 20101231 18665156 20524982 20512989 20007298 19418558 19822196 20727157 17162532 20514400 16807293 19208518 11831363 16830150 19394651 16935385 18056438 16502159 18691550 20214788 18210153 17173139 19701751 16288022 20084675 16698587 18494052 16878318 16681979 18506893 19383236 19919837 21159647 16569478 20432363 17761372 3084413 18788625 17428255 10672840 19519916 17978847 20935162 19539802 16540662
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.781917145
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9515504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5619152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.4618022660 16973168
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.832727394 21159647 17174075 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.728800419 9211117 10589399 9142499 17551590 9664655 16925845 9224671 14991402 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7216575769 8888407 17688650
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4819085960 11739529 11834606 12153990 16485898 11461765 16177239 17906064 12705907 12594235 17522070 19416960 11421492 10774834 16227642 10663392 19923254 18071297 12958197 11743745 15968718 11529661 2444490 14550746 19370779 11287661 16109766 19420014 16781746 18713872 16081117 12540782 14725611 19739265 16393943 15619225 17562736 10915739 14986274 12392966 19164858
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4819107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.481733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 14.1519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.1520387270 21071580
MESH:D005234 Fatty Liver Valproic Acid 14.1519224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Cyclosporine 9.4212639820 12168785
MESH:D005355 Fibrosis Tretinoin 9.4217994277
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 5.499931084 16076760 11953799
MESH:D006973 Hypertension Cyclosporine 5.4910903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9719850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.1217339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.1217712046 16140955 17339181 16935935 9834237 16788101 19642359 16823087 17649720 19225113 16891316 17301526 17107899 19029980 17217047 16766008 19035177 19075265 17368321 17361223 16331271 15748426 17294898 17506722 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118665156 20032147 18522880 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.7712969438 16610002 19460945 19784758 16611625 12587719 19014921 11587558
MESH:D008107 Liver Diseases Arsenic 6.7711134558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 7.9216368122
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9212112319 20492335 20101389 20405173 19254457 9163691 19638242 2422723 19690152 21047994 20452335 19073162 19294768 16942905 19850985 20501860 19996281 19833225 18977376 15885732 21167192 18754104 20434301 20118626 12771043 10737359 20137499 19426721 19499222 18644402 21278145 19256749 19812893 18978307 19642983 19427195 20583210 2862719 19551842 15175105 21071580 19255062 19090486 18648771
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7321159647 9362446 18253720 18308698 18093689 2563599 19004024 18775883 19126423 19539802 17174075 18544905 18164116 18079962 3124819 18282651 17942915 16267830 19519916 19009564 16842330 17854601
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Arsenic 2.6519168569 17976673 17306315
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6520512841 20970405 6695378 21163286
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.7017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7017596541
MESH:D017202 Myocardial Ischemia Arsenic 4.1215371236
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.623581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.4816946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Arsenic 12.8316620997
MESH:D009436 Neural Tube Defects Tretinoin 12.839142499
MESH:D009436 Neural Tube Defects Valproic Acid 12.838888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D010051 Ovarian Neoplasms Arsenic 5.1517306315
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1516936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4316540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4315976015
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2315371236 6392382 16905509
MESH:D011230 Precancerous Conditions Cyclosporine 9.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.462563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.5816140617
MESH:D011507 Proteinuria Arsenic 9.9021343184
MESH:D011507 Proteinuria Tretinoin 9.9016636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.4916283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.4919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8517978042 15475178 16876388 3137016 14763951 11738929 1511512 11044598
MESH:D012871 Skin Diseases Arsenic 2.7817453740 16353154 15952646 16759981 17050553 16702368 17938729 19834688 18709164 6392382 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.1616251483 19538983 17050553 15504454 17029826 17976673
MESH:D012878 Skin Neoplasms Tretinoin 6.1616467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4518456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4517261132
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.617505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8718640142 19322015 19429237 17976673 15987713 11144890 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved