AutismKB 2.0

Annotation Detail for SCCPDH


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Basic Information Top
Gene Symbol:SCCPDH ( FLJ43187,NET11,RP11-439E19.2 )
Gene Full Name: saccharopine dehydrogenase (putative)
Band: 1q44
Quick LinksEntrez ID:51097; OMIM: NA; Uniprot ID:SCPDH_HUMAN; ENSEMBL ID: ENSG00000143653; HGNC ID: 24275
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SCCPDH mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SCCPDH mRNAaffects expression 17562736
C109238 acyline acyline results in increased expression of SCCPDH mRNAincreases expression 17510436
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SCCPDH proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in decreased expression of SCCPDH mRNAdecreases expression 17991464
D001104 Arbutin Arbutin results in increased expression of SCCPDH mRNAincreases expression 17103032
D016572 Cyclosporine Cyclosporine results in decreased expression of SCCPDH mRNAdecreases expression 20106945
D005472 Fluorouracil Fluorouracil results in increased expression of SCCPDH mRNAincreases expression 16101138
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SCCPDH mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4717638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000740 Anemia Fluorouracil 3.9015504547 16511603 17963324
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9920041841 18057881 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.0519698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.7819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7819483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4518357371 19217205 18608205 16595493 16110121 15136595 16557594
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.803084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8017045692 17088986 18930000 17971768 16332177 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5418986760 16280240 16757204 17066447
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9519225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2618772588 17725105 16340194 17172411 16510598 17287894 15001691 17169374 17018589 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016303861 15289873 16331619 20501625 18383874 14970324 18509181 18448328 17594712 17255274 17016601 16391804 17454858 18802399 16282729 16524972 17094418 17695437 18949393 18288408 15148649 17401013
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5416485898 12540782 16393943 11529661 12392966 19085960 2444490 16081117 17522070 11461765 12594235 14986274 19370779 12153990 19420014 11743745 15968718 17906064 11421492 18713872 19923254 11834606 19164858 16227642 15619225 11739529 17562736 14725611 10774834 11287661 16781746 19416960 10915739 12705907 12958197 19739265 16177239 18071297 14550746 16109766 10663392
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.5415265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4916481741 15173087 17638652 16337965 16785472
MESH:D005234 Fatty Liver Amiodarone 14.3314986274
MESH:D005234 Fatty Liver Cyclosporine 14.3319224547
MESH:D005234 Fatty Liver pirinixic acid 14.3320131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.4012168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15162350 15102660
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly Amiodarone 9.4515265979
MESH:D006529 Hepatomegaly pirinixic acid 9.4518467677 19772884 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.089751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007037 Hypothyroidism Amiodarone 4.7717991464 18020914
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.4412371664
MESH:D007680 Kidney Neoplasms Fluorouracil 13.4416985049
MESH:D008064 Lipidoses Amiodarone 3.6517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 16611625 19784758 11587558 19460945 12587719 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.8515890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Fluorouracil 7.8516603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.8520007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.868603461
MESH:D008133 Long QT Syndrome Amiodarone 3.7311989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.5012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6314755239
MESH:D008175 Lung Neoplasms Fluorouracil 2.6315246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7918986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009181 Mycoses Amiodarone 5.2217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009369 Neoplasms Fluorouracil 5.2918239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 5.2917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6212819281 16049721
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216500647 19003803 15113037 16929163
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3819082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9212490602 12832656 11597910
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 18722050 15538739 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 16951190 17172411 19015929 17522103 18567086 15786421 16424979 19084572 17498489
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D013959 Thyroid Diseases Amiodarone 5.0819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1218020914 19584973
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D016171 Torsades de Pointes Amiodarone 4.4711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3516049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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