Annotation Detail for APH1A
Basic Information Top
| Gene Symbol: | APH1A ( 6530402N02Rik,APH-1,APH-1A,CGI-78 ) |
|---|---|
| Gene Full Name: | anterior pharynx defective 1 homolog A (C. elegans) |
| Band: | 1q21.2 |
| Quick Links | Entrez ID:51107; OMIM: 607629; Uniprot ID:APH1A_HUMAN; ENSEMBL ID: ENSG00000117362; HGNC ID: 29509 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa05010 | Alzheimer's disease |
| hsa04330 | Notch signaling pathway |
| Pathway ID | Pathway Name |
|---|---|
| Signalling by NGF | |
| Signaling by Notch |
| Pathway ID | Pathway Name |
|---|---|
| 200013 | Notch signaling pathway |
| 200170 | Syndecan-3-mediated signaling events |
| 200103 | p75(NTR)-mediated signaling |
| 200052 | Presenilin action in Notch and Wnt signaling |
| Pathway ID | Pathway Name |
|---|---|
| P00003 | Alzheimer disease-amyloid secretase pathway |
| P00004 | Alzheimer disease-presenilin pathway |
| P00045 | Notch signaling pathway |
| No data |
| No data |
| No data |
| No data |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of APH1A mRNA | affects expression | 17562736 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000799 | Angioedema | Acetaminophen | 5.26 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.86 | 10977129 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.69 | 10915739 2444490 10663392 19923254 17522070 16393943 19739265 17562736 11287661 15619225 14725611 12153990 12705907 19164858 11421492 19370779 12540782 12594235 12958197 16485898 11529661 11739529 16227642 11743745 11461765 18713872 14550746 16109766 19416960 12392966 18071297 15968718 16781746 16177239 17906064 16081117 14986274 19420014 19085960 10774834 11834606 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 5.51 | 19426721 | |
| MESH:D005756 | Gastritis | Acetaminophen | 5.09 | 16983495 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.15 | 16870215 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.47 | 15629191 12587719 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.72 | 19014921 12587719 19784758 11587558 19460945 16611625 12969438 16610002 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.81 | 17185352 16871587 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.47 | 19513568 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.36 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.87 | 16870215 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.67 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:05010 | Alzheimer's disease |
| KEGG:04330 | Notch signaling pathway |
| REACT:299 | Signaling by Notch |
| REACT:11061 | Signalling by NGF |
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