AutismKB 2.0

Annotation Detail for LACTB2


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Basic Information Top
Gene Symbol:LACTB2 ( - )
Gene Full Name: lactamase, beta 2
Band: 8q13.3
Quick LinksEntrez ID:51110; OMIM: NA; Uniprot ID:LACB2_HUMAN; ENSEMBL ID: ENSG00000147592; HGNC ID: 18512
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of LACTB2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LACTB2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of LACTB2 mRNAincreases expression 20106945
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LACTB2 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of LACTB2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LACTB2 mRNAaffects cotreatment|affects expression 17602206
D002117 Calcitriol Calcitriol results in increased expression of LACTB2 mRNAincreases expression 16002434
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of LACTB2 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of LACTB2 mRNAaffects cotreatment|increases expression 17347304
C006253 pirinixic acid pirinixic acid results in decreased expression of LACTB2 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of LACTB2 mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LACTB2 mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.1217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1214514962 15322242 11752688
MESH:D000138 Acidosis Ethanol 4.6911192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.583712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.586695378
MESH:D000236 Adenoma Diethylnitrosamine 11.586695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.4616434500 19052882 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4616835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5415451040 15451039
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D000853 Anophthalmos Ethanol 5.0015513904
MESH:D001008 Anxiety Disorders Ethanol 4.1211141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9611237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002056 Burns Ethanol 4.8316374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.743581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7419418558 20214788 20101231 16935385 17162532 19171122 19107877 20935162 19383236 3084413 20524982 19919837 20432363 19519916 18494052 17978847 16540662 18506893 16681979 17055752 18691550 17138121 18056438 17761372 21159647 18788625 16698587 19052882 16779866 16502159 19208518 16878318 19822196 16328049 18971187 17173139 16830150 19701751 18978308 19539802 3581430 18210153 19335982 17428255 10737359 18393292 18665156 10672840 20007298 20514400 20512989 20727157 18785209 16569478 20084675 16288022 19394651 11831363 16807293
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.7415289165 15763234 18788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8111237771
MESH:D006332 Cardiomegaly Ethanol 7.0919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.717505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.7117174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.999022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.9919486331
MESH:D002779 Cholestasis pirinixic acid 13.9919176532
MESH:D002971 Cleft Lip Ethanol 3.6515513904
MESH:D002972 Cleft Palate Ethanol 6.1315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1315340226 8697196 12621046 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6715513904 19302082 10194807 11198716 11873399 15451039 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6715322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9712868966 11906362 18759878 14531868 8156756 8970840 11298694 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.4311289319 18289764 1440618 18692083 16192314 9653073 6679447 8291058 9328219 18648102 9022650 6482804 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4311739529 11461765 19420014 18071297 19923254 19416960 2444490 17906064 15968718 17522070 10774834 14725611 17562736 16781746 10663392 11421492 16485898 10915739 12153990 19085960 12392966 19739265 18713872 12958197 19370779 14986274 11743745 16081117 12594235 11287661 14550746 12705907 16393943 16177239 19164858 11834606 11529661 16227642 15619225 16109766 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4319107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.4311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.473581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4716530937
MESH:D004938 Esophageal Neoplasms Ethanol 7.4716704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 26.2719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 26.2721071580 20387270
MESH:D005234 Fatty Liver Ethanol 26.2719236843 16409862 18620774
MESH:D005234 Fatty Liver Fish Oils 26.2718620774
MESH:D005234 Fatty Liver pirinixic acid 26.2720131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4916946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 11.8716983495
MESH:D005756 Gastritis Ethanol 11.8715046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 16959395 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 8.1916870215
MESH:D006930 Hyperalgesia Ethanol 8.1918783367
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Fish Oils 4.9015752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.7211484837
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 10.5915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.058314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.666582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6612371664
MESH:D007859 Learning Disorders Ethanol 4.3915451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9117676605
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0618522880 19638242 20032147 18407596 18665156
MESH:D008103 Liver Cirrhosis Ethanol 7.0615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2918295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008107 Liver Diseases Acetaminophen 4.0119460945 11587558 12969438 16610002 19784758 12587719 19014921 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8317207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7621137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 14.7617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.7619294768 20501860 20452335 21167192 19638242 20118626 19499222 18978307 12112319 19255062 19812893 19427195 20405173 19996281 18754104 15885732 20137499 19642983 21278145 19833225 19690152 19073162 18648771 2422723 19256749 15175105 19426721 2862719 20101389 19254457 9163691 19090486 18977376 20583210 12771043 19850985 18644402 21047994 10737359 16942905 20492335 20434301 19551842 21071580
MESH:D008113 Liver Neoplasms pirinixic acid 14.7620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.28598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.283124819 18544905 18093689 18775883 19126423 18079962 17174075 16267830 21159647 19009564 18164116 19539802 18253720 17942915 18282651 19004024 9362446 17854601 19519916 18308698 16842330 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4220064080 20464547 20869020 18569708 18520028 18816296 6695378 20135361 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4221163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008569 Memory Disorders Ethanol 4.3518411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.873581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.873581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5916540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.5912384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.362563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11222880 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2415754350 18247401 16289102 16644109 12479363
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures Ethanol 3.269754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.462093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4618456281
MESH:D013274 Stomach Neoplasms Ethanol 3.4618456281
MESH:D013276 Stomach Ulcer Ethanol 3.679562338 11906479 17189318 17918041 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.399754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.487505956 6582329 6587162 3712494 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.487505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.138074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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