Annotation Detail for SAR1B
Basic Information Top
| Gene Symbol: | SAR1B ( ANDD,CMRD,GTBPB,SARA2 ) |
|---|---|
| Gene Full Name: | SAR1 homolog B (S. cerevisiae) |
| Band: | 5q31.1 |
| Quick Links | Entrez ID:51128; OMIM: 607690; Uniprot ID:SAR1B_HUMAN; ENSEMBL ID: ENSG00000152700; HGNC ID: 10535 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04141 | Protein processing in endoplasmic reticulum |
| Pathway ID | Pathway Name |
|---|---|
| Membrane Trafficking |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500009 | COPII (Coat Protein 2) Mediated Vesicle Transport |
| 500796 | Chylomicron-mediated lipid transport |
| No data |
| No data |
| No data |
| No data |
| Desease Name |
|---|
| Chylomicron retention disease |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of SAR1B mRNA | increases expression | 15336504 |
| D002995 | Clofibric Acid | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SAR1B mRNA | affects cotreatment|affects expression | 17602206 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SAR1B mRNA | affects cotreatment|affects expression | 17602206 |
| D007657 | Ketone Bodies | Ketone Bodies results in decreased expression of SAR1B mRNA | decreases expression | 16807920 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SAR1B mRNA | affects binding|increases activity|increases expression | 19710929 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of SAR1B mRNA | increases expression | 18301758 17426115 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.52 | 18653653 | |
| MESH:D000236 | Adenoma | Diethylnitrosamine | 3.03 | 10737359 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 11.96 | 18056438 19061943 17162532 17620307 16434500 19052882 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 11.96 | 16434500 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.52 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.19 | 17474063 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.87 | 16698587 19539802 16540662 20524982 19394651 17428255 18971187 18210153 3581430 20007298 17162532 20727157 20101231 19052882 20432363 17138121 18056438 16569478 16807293 3084413 18785209 19701751 19519916 16878318 16830150 16779866 10737359 20214788 16681979 16935385 20084675 18506893 10672840 20935162 19107877 19171122 17055752 16288022 19418558 20514400 18691550 16502159 19383236 17761372 18494052 17978847 20512989 19822196 19919837 16328049 19208518 18393292 18978308 11831363 19335982 21159647 18665156 18788625 17173139 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 3.09 | 7505956 17174075 2727394 21159647 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 4.01 | 19052882 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 3.08 | 19176532 | |
| MESH:C535460 | Chylomicron retention disease | marker/mechanism | |||
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.56 | 18249437 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.25 | 20387270 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 2.13 | 19107877 | |
| MESH:D004487 | Edema | pirinixic acid | 2.85 | 12083418 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 5.73 | 16302075 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 8.95 | 21071580 20387270 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 8.95 | 19236843 20131406 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.73 | 20558911 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 3.48 | 16221962 19176532 18467677 19772884 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.53 | 20558911 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 2.53 | 18785209 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.85 | 16306350 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 2.99 | 18522880 18407596 20032147 18665156 19638242 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 1.35 | 15474484 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 2.16 | 17034775 | |
| MESH:D008113 | Liver Neoplasms | Clofibric Acid | 8.12 | 17602206 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 8.12 | 15175105 18977376 19996281 19638242 10737359 18754104 20583210 21278145 21167192 16942905 15885732 12112319 20501860 18644402 20434301 19294768 2862719 19812893 19090486 9163691 18648771 19499222 21071580 19833225 20101389 19256749 20118626 20452335 20405173 19690152 20492335 20137499 19255062 19427195 21047994 19426721 2422723 19073162 19254457 12771043 19850985 18978307 19551842 19642983 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 8.12 | 20007298 16377806 15890375 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 2.83 | 17942915 19539802 3124819 18775883 16842330 19009564 21159647 16267830 17174075 19126423 18093689 18544905 9362446 18079962 18282651 18253720 19004024 18164116 17854601 2563599 19519916 18308698 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.76 | 21163286 6695378 20970405 20512841 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.99 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.26 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 3.22 | 16411023 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.68 | 3581430 9029167 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 2.09 | 17405874 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.65 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 5.73 | 20387270 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.88 | 20558911 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.52 | 16540662 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 3.88 | 2563599 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.53 | 19058328 | |
| MESH:D012878 | Skin Neoplasms | tert-Butylhydroperoxide | 2.83 | 8532709 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.25 | 7505956 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:11123 | Membrane Trafficking |
| REACT:17015 | Metabolism of proteins |
| KEGG:04141 | Protein processing in endoplasmic reticulum |
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