AutismKB 2.0

Annotation Detail for LEF1


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Basic Information Top
Gene Symbol:LEF1 ( DKFZp586H0919,FLJ46390,TCF1ALPHA )
Gene Full Name: lymphoid enhancer-binding factor 1
Band: 4q25
Quick LinksEntrez ID:51176; OMIM: 153245; Uniprot ID:LEF1_HUMAN; ENSEMBL ID: ENSG00000138795; HGNC ID: 6551
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa04310Wnt signaling pathway
hsa05216Thyroid cancer
hsa04520Adherens junction
hsa05221Acute myeloid leukemia
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05217Basal cell carcinoma
hsa05215Prostate cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200130C-MYB transcription factor network
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
other metabolic traits
METABOLIC
Desease Name
Other metabolic traits
Desease Name
Sebaceous tumors, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of LEF1 mRNAdecreases expression 15612046
C048460 3-deazaneplanocin [3-deazaneplanocin co-treated with trichostatin A] affects the expression of LEF1 proteinaffects cotreatment|affects expression 18538736
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of LEF1 mRNAaffects cotreatment|decreases expression 17093179
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LEF1 mRNAaffects expression 16483693
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNAaffects cotreatment|increases expression 16272459
C014347 decitabine decitabine results in decreased expression of LEF1 mRNAdecreases expression 19387464
D015946 Ethylene Dibromide Ethylene Dibromide results in decreased expression of LEF1 mRNAdecreases expression 15612046
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNAaffects cotreatment|decreases expression 16931933
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of LEF1 mRNAaffects cotreatment|decreases expression 17093179
D004642 Emodin Emodin results in decreased expression of LEF1 mRNAdecreases expression 15612046
D004958 Estradiol Estradiol promotes the reaction [CTNNB1 protein binds to LEF1 protein]affects binding|increases reaction 17170212
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LEF1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEF1 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of LEF1 mRNAincreases expression 18035473
C004312 glycidol glycidol results in decreased expression of LEF1 mRNAdecreases expression 15612046
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of LEF1 mRNAaffects cotreatment|increases expression 17183730
D018021 Lithium Chloride Lithium Chloride promotes the reaction [LEF1 protein binds to GCG promoter]affects binding|increases reaction 19582394
D018021 Lithium Chloride Lithium Chloride promotes the reaction [LEF1 protein binds to GIP promoter]affects binding|increases reaction 19582394
D018021 Lithium Chloride Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GCG promoter]affects binding|affects cotreatment|increases reaction 19582394
D018021 Lithium Chloride Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GIP promoter]affects binding|affects cotreatment|increases reaction 19582394
C036868 methyl carbamate methyl carbamate results in decreased expression of LEF1 mRNAdecreases expression 15612046
D009151 Mustard Gas Mustard Gas results in increased expression of LEF1 mRNAincreases expression 15674843
D010100 Oxygen [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNAaffects cotreatment|increases expression 16272459
D011794 Quercetin Quercetin affects the expression of LEF1 mRNAaffects expression 17148581
D011794 Quercetin Quercetin results in decreased expression of LEF1 mRNAdecreases expression 17148581
D015125 Oxyquinoline Oxyquinoline results in decreased expression of LEF1 mRNAdecreases expression 15612046
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNAaffects cotreatment|decreases expression 16931933
C105686 SU 5402 SU 5402 results in decreased expression of LEF1 mRNAdecreases expression 15255957
D013467 Sulindac Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein]affects binding|decreases activity 11751639
D013629 Tamoxifen Tamoxifen results in increased expression of LEF1 mRNAincreases expression 15590111
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEF1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LEF1 mRNAincreases expression 19933214
17586704
C012589 trichostatin A [3-deazaneplanocin co-treated with trichostatin A] affects the expression of LEF1 proteinaffects cotreatment|affects expression 18538736
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of LEF1 mRNAaffects cotreatment|increases expression 17183730
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNAaffects cotreatment|decreases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.1314745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.1314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4415322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.448875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6919490988
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.579612607
MESH:D058186 Acute Kidney Injury Sulindac 4.087897758
MESH:D055371 Acute Lung Injury Oxygen 4.2916759491
MESH:D000230 Adenocarcinoma Estradiol 6.7411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7414692618
MESH:D000230 Adenocarcinoma Sulindac 6.7411910360
MESH:D000236 Adenoma Sulindac 3.6310223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1216835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3712394442 11535846 19003578 11874996 16460482 17611924 15623613
MESH:D000550 Amblyopia Valproic Acid 4.9717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0017084956
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D000860 Anoxia Oxygen 4.7920872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.3717497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D001249 Asthma Mustard Gas 2.6310378619
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7115336622
MESH:D050197 Atherosclerosis Oxygen 3.6516391483
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518558336 17688650 17507914 19460635 18316065 18396377 15238991 19232924 20603192 18177632 18985861 18940202 17157402 16609825 18775368
MESH:D001327 Autoimmune Diseases Quercetin 4.1519761891
MESH:D001714 Bipolar Disorder Valproic Acid 2.9417594078 20046352
MESH:D001768 Blister Mustard Gas 4.9019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.478888407
MESH:D001913 Bowen's Disease Sulindac 5.0911207687
MESH:D001932 Brain Neoplasms glycidol 5.2010528639 12562636
MESH:D001943 Breast Neoplasms decitabine 5.5618320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 5.5617018787 17289903 17261762 12948864 14630087 18497071 16675129 19861407
MESH:D001943 Breast Neoplasms Ethylene Dibromide 5.5611921183
MESH:D001943 Breast Neoplasms glycidol 5.5611921183
MESH:D001943 Breast Neoplasms Oxygen 5.5617263869
MESH:D001943 Breast Neoplasms Quercetin 5.5618628248
MESH:D001943 Breast Neoplasms Sulindac 5.5616642371
MESH:D001943 Breast Neoplasms Tamoxifen 5.5617440819 18815881 19200415 18629630 19289846 20544844 19487384 19189212 19288272 19189210 17049068 15668708 20065188 17893378 21138602 18855134 19410462 18351453 16873071 19142967 18425577 20135344 20005174 15565566 18984771 19115204 20859285 19011961 19066611 19059307 16818667 16273361 17242785 19155303 20390343 19084267 18997820 11161223 18821012 16202921 17261762 19221464 21152245 19103187 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7117687719 10378619
MESH:D002105 Cadmium Poisoning Quercetin 5.2816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.203084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.2016924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.2019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.2016924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7017234771
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5219215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3917572228
MESH:D006332 Cardiomegaly Quercetin 6.3219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.4414688030
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6018566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6815861022 16919318 17110522 16105132 11677210 17681005 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.998697196 12621046 15340226 15668235 16354765
MESH:D003110 Colonic Neoplasms decitabine 5.6817616700
MESH:D003110 Colonic Neoplasms Quercetin 5.6811134977 17148506 19056647 19440933 17191121 16640504 15741050
MESH:D003110 Colonic Neoplasms Sulindac 5.6812902858 12458338
MESH:D015179 Colorectal Neoplasms decitabine 3.4718981723
MESH:D015179 Colorectal Neoplasms Quercetin 3.4718095365 18852136
MESH:D015179 Colorectal Neoplasms Sulindac 3.4711197048 10666051 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.3917688650 8888407 16575769
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1019031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5219496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.1119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1119279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.9312861449 17621415
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3710774834 11834606 10663392 16109766 11743745 10915739 14550746 12958197 12540782 14986274 19420014 19923254 12392966 16177239 11529661 17906064 12153990 2444490 18713872 19085960 11739529 16227642 15619225 19416960 17562736 18071297 12594235 15968718 16393943 16781746 19164858 11287661 19370779 12705907 16485898 11421492 11461765 16081117 17522070 19739265 14725611
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 8.372862719
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.371733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Lamivudine 12.7615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.7611462148
MESH:D004362 Drug Toxicity Zidovudine 12.7615040536
MESH:D004417 Dyspnea Oxygen 4.5720016425
MESH:D004421 Dystonia Valproic Acid 3.811851702
MESH:D004487 Edema Mustard Gas 6.0711428631 11402378 9260866 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.1419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.1419294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.8211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.8216202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Sulindac 8.4315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.4310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.903659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.377562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.803659116
MESH:D004890 Erythema Mustard Gas 4.909357497
MESH:D004938 Esophageal Neoplasms Sulindac 3.0712235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.8815345470
MESH:D005234 Fatty Liver Tamoxifen 16.8814986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 16.8819224547 14986274
MESH:D005234 Fatty Liver Zidovudine 16.8818299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8818558336 8888407
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.0714745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.0714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.7619069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.7619069698
MESH:D005355 Fibrosis Emodin 13.5019474275
MESH:D005355 Fibrosis Quercetin 13.5019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5020067830
MESH:D005739 Gas Poisoning Oxygen 4.9520016425
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7611910360
MESH:D005909 Glioblastoma Quercetin 7.0019804834
MESH:D005909 Glioblastoma trichostatin A 7.0018801729
MESH:D005910 Glioma Quercetin 2.9517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3119215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1911294989 10048152
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 4.8513678655
MESH:D006402 Hematologic Diseases Zidovudine 4.4712579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006509 Hepatitis B Lamivudine 4.8617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.8615274664 15631357 15309715 16476009 12044531
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6412621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D015658 HIV Infections Lamivudine 10.3211141242 17530837 9296927 20032539
MESH:D015658 HIV Infections Saquinavir 10.3211141242 15388451
MESH:D015658 HIV Infections Zidovudine 10.3220032539 11141242 11698656 17358032 11363243
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6017688650
MESH:D006869 Hydronephrosis Lithium Chloride 12.1419797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 12.1416959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006943 Hyperglycemia Quercetin 3.8011834736 18262572
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.2817604070
MESH:D006973 Hypertension Quercetin 4.8918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3716612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male decitabine 6.1417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007249 Inflammation Flavonoids 14.4217296493
MESH:D007249 Inflammation Mustard Gas 14.4211428631 8975870 11428647 17524151 11402378 9260866 9357497 11428620 16001271
MESH:D007249 Inflammation Sulindac 14.423291741
MESH:D007249 Inflammation Tamoxifen 14.4219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.4212200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.2416624496
MESH:D007333 Insulin Resistance Estradiol 2.8016393666 16627594
MESH:D007414 Intestinal Neoplasms Sulindac 4.4112351151 12584176 10223192 12628509 12663524 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.7411245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007627 Keloid Quercetin 4.7017086741
MESH:D007674 Kidney Diseases Acetaminophen 13.3012587719 15629191
MESH:D007674 Kidney Diseases Estradiol 13.3015618244
MESH:D007674 Kidney Diseases Ethylene Dibromide 13.3012628311
MESH:D007674 Kidney Diseases Quercetin 13.3016962696
MESH:D007680 Kidney Neoplasms Estradiol 11.2915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.2918625569
MESH:D007680 Kidney Neoplasms Zidovudine 11.2912579204
MESH:D007938 Leukemia decitabine 6.1418980019 19235587
MESH:D007938 Leukemia Quercetin 6.1417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 9.5117077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 9.5120370541
MESH:D007951 Leukemia, Myeloid decitabine 3.7719117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.9618206229 18460780 19387464 19010910 18704418 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.9618206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.9616294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1918055864
MESH:D008064 Lipidoses Tamoxifen 2.9717567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0612468960
MESH:D008106 Liver Cirrhosis, Experimental Emodin 6.3915288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.3912741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3912878042
MESH:D008107 Liver Diseases Acetaminophen 4.0119460945 16610002 12969438 12587719 19784758 11587558 16611625 19014921
MESH:D008107 Liver Diseases Sulindac 4.0114986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0116871587 17185352
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 9.9218177683
MESH:D008113 Liver Neoplasms Quercetin 9.9218980244
MESH:D008113 Liver Neoplasms Tamoxifen 9.9216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.9216984957
MESH:D008114 Liver Neoplasms, Experimental glycidol 9.1812692647 12562636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 9.1819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1812151625
MESH:D008171 Lung Diseases Mustard Gas 3.2818702808 18161513
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0017228818
MESH:D055370 Lung Injury Oxygen 4.2518339021
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 12.3915390079 19359593 16337739 11696405 11246140 18597497 19925653
MESH:D008175 Lung Neoplasms glycidol 12.3912562636 12692647
MESH:D008175 Lung Neoplasms Mustard Gas 12.398781369 3148597
MESH:D008175 Lung Neoplasms Quercetin 12.3916280456
MESH:D008175 Lung Neoplasms Sulindac 12.3919359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 12.3918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.3919555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 12.3918800350
MESH:D008223 Lymphoma decitabine 3.2319470736
MESH:D015674 Mammary Neoplasms, Animal glycidol 9.6912692647 8818859 12562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.6919428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 17.121500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.1211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 17.1211921183
MESH:D008325 Mammary Neoplasms, Experimental glycidol 17.1211921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.1211731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7619453300
MESH:D008545 Melanoma decitabine 6.9716505122 17785578
MESH:D008545 Melanoma Sulindac 6.9716642371
MESH:D008545 Melanoma Tamoxifen 6.9712393984 19393235
MESH:D008545 Melanoma trichostatin A 6.9716505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5717358032
MESH:D008881 Migraine Disorders Valproic Acid 3.0118803445 18765137
MESH:D009062 Mouth Neoplasms glycidol 5.1912562636
MESH:D009101 Multiple Myeloma decitabine 7.0418172295
MESH:D009101 Multiple Myeloma trichostatin A 7.0418172295
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.4213678655
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.798888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0119010910 19157545 16882708 18608210
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.0117596541
MESH:D009203 Myocardial Infarction Quercetin 2.8819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9016810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.9019207477
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4319410462
MESH:D009369 Neoplasms decitabine 4.9019470736 19116145 17925555
MESH:D009369 Neoplasms Quercetin 4.9015185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009421 Nervous System Malformations Estradiol 8.6316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.9616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8218514411
MESH:D019636 Neurodegenerative Diseases Sulindac 7.8217266991 16850258
MESH:D020078 Neurogenic Inflammation Quercetin 4.1217929310
MESH:D009503 Neutropenia Mustard Gas 3.737688884 16761898
MESH:D009669 Nose Neoplasms Ethylene Dibromide 5.259385384
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9819495926
MESH:D010051 Ovarian Neoplasms decitabine 10.6519331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 10.6519401270
MESH:D010051 Ovarian Neoplasms Quercetin 10.6519005980
MESH:D010051 Ovarian Neoplasms trichostatin A 10.6519331143
MESH:D010146 Pain Acetaminophen 6.2216870215
MESH:D010146 Pain Sulindac 6.223291741
MESH:D010190 Pancreatic Neoplasms decitabine 11.6519294695
MESH:D010190 Pancreatic Neoplasms Quercetin 11.6516965848
MESH:D010190 Pancreatic Neoplasms Sulindac 11.6516820089 11504793
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.6519294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.9011893704
MESH:D011041 Poisoning Mustard Gas 3.5615727166
MESH:D011141 Polyuria Lithium Chloride 5.7319692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Quercetin 3.7619056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5911399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.5920603192
MESH:D055728 Primary Myelofibrosis decitabine 11.5717616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.5717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.1716740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.1717292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1715067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1719789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 8.6515861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.6518058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.2712752131 11422049
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8310334151 17894541 17620002 17266442 17720292
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.2718339021 17627322
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.279296927
MESH:D012208 Rhabdomyosarcoma decitabine 10.1719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.1719155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.2816862918
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012626 Sebaceous Gland Neoplasms marker/mechanism
MESH:D012640 Seizures Valproic Acid 2.5715475178 1511512 16876388 11044598 17978042 3137016 11738929 14763951
MESH:D012871 Skin Diseases Mustard Gas 2.6512880345 16961503 15451306
MESH:D012878 Skin Neoplasms glycidol 5.8712562636 12692647
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6716709447
MESH:D013088 Spermatocele Tamoxifen 10.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2712833885
MESH:D013274 Stomach Neoplasms decitabine 4.7319037991
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 4.733768853
MESH:D013274 Stomach Neoplasms glycidol 4.7311397402 8818859 12562636 12692647
MESH:D013274 Stomach Neoplasms Zidovudine 4.7317696246
MESH:D013398 Sudden Infant Death Oxygen 5.2812563064
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms decitabine 7.3617967635
MESH:D013964 Thyroid Neoplasms glycidol 7.3612562636
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D014178 Translocation, Genetic Valproic Acid 4.9717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.263119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.8019087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.8016720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8017572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.388888407
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.9014692618
MESH:D014594 Uterine Neoplasms glycidol 14.9012562636 12692647
MESH:D014594 Uterine Neoplasms Sulindac 14.9018645019
MESH:D014604 Uveal Neoplasms decitabine 4.6517785578
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5012579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04520 Adherens junction
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05217 Basal cell carcinoma
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:05216 Thyroid cancer
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30331
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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