AutismKB 2.0

Annotation Detail for HAO2


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Basic Information Top
Gene Symbol:HAO2 ( GIG16,HAOX2 )
Gene Full Name: hydroxyacid oxidase 2 (long chain)
Band: 1p12
Quick LinksEntrez ID:51179; OMIM: 605176; Uniprot ID:HAOX2_HUMAN; ENSEMBL ID: ENSG00000116882; HGNC ID: 4810
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00630Glyoxylate and dicarboxylate metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HAO2 mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HAO2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of HAO2 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HAO2 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of HAO2 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HAO2 mRNAdecreases expression 20106945
D002994 Clofibrate Clofibrate affects the expression of HAO2 mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HAO2 mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin coumarin results in decreased expression of HAO2 mRNAdecreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of HAO2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HAO2 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of HAO2 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of HAO2 mRNAdecreases expression 17072980
D004958 Estradiol Estradiol results in decreased expression of HAO2 mRNAdecreases expression 20106945
D000431 Ethanol Ethanol results in increased expression of HAO2 mRNAincreases expression 16946407
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HAO2 mRNAincreases expression 15901920
D005001 Ethionine Ethionine affects the expression of HAO2 mRNAaffects expression 19483382
D019833 Genistein Genistein results in increased expression of HAO2 mRNAincreases expression 15901920
C029424 hydrazine hydrazine results in decreased expression of HAO2 mRNAdecreases expression 15282401
D009853 Omeprazole Omeprazole affects the expression of HAO2 mRNAaffects expression 19483382
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of HAO2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of HAO2 mRNAincreases expression 19270015
19482888
D010795 Phthalic Acids Phthalic Acids results in decreased expression of HAO2 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of HAO2 mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid affects the expression of HAO2 mRNAaffects expression 19483382
C045950 propiconazole propiconazole results in increased expression of HAO2 mRNAincreases expression 16643972
D011441 Propylthiouracil Propylthiouracil affects the expression of HAO2 mRNAaffects expression 19483382
C488333 Ro 65-7199 Ro 65-7199 affects the expression of HAO2 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of HAO2 mRNAaffects expression 14610520
C446685 systhane systhane results in decreased expression of HAO2 mRNAdecreases expression 16643972
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in increased expression of HAO2 mRNAincreases expression 20056577
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAO2 mRNAdecreases expression 20106945
D013853 Thioacetamide Thioacetamide affects the expression of HAO2 mRNAaffects expression 19483382
C032910 triadimefon triadimefon results in decreased expression of HAO2 mRNAdecreases expression 16643972
D014303 Trinitrotoluene Trinitrotoluene affects the expression of HAO2 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 17.8218926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.826195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.8215322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 17.827525203
MESH:D000138 Acidosis Ammonium Chloride 9.4318287403
MESH:D000138 Acidosis Ethanol 9.4311192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.6420127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.6416033868
MESH:D000230 Adenocarcinoma Estradiol 12.6411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.6414692618
MESH:D000230 Adenocarcinoma Genistein 12.6411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.503712494
MESH:D000236 Adenoma Benzo(a)pyrene 14.506695378
MESH:D000236 Adenoma Diethylnitrosamine 14.506695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 14.5019555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.2917162532 17620307 16434500 19061943 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.2917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.2916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.2916835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0015451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000853 Anophthalmos Ethanol 4.5215513904
MESH:D001008 Anxiety Disorders Ethanol 3.7611141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5418057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4715885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.6718651412 19698954
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1520106747
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 3.4019211157
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7011289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.8119483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.8119483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.8119483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.8119483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.8119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.8119483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.8119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 52.8112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.8119483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2220146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D001943 Breast Neoplasms Estradiol 2.2219861407 17261762 12948864 14630087 17289903 17018787 16675129 18497071
MESH:D001943 Breast Neoplasms Genistein 2.2216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2220435547
MESH:D002056 Burns Ethanol 4.3516374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002277 Carcinoma Dimethylnitrosamine 7.5519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 18.813581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.8112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 18.811701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.8118056438 17428255 18665156 16830150 19418558 20512989 18691550 20935162 10737359 19822196 18971187 17162532 20432363 16698587 16681979 18978308 16878318 19519916 19052882 20524982 17173139 20007298 16288022 20101231 19919837 20084675 16502159 18494052 16328049 19107877 20214788 19383236 10672840 21159647 17138121 3581430 18506893 19335982 18393292 19394651 18788625 16779866 17761372 11831363 17055752 18785209 19539802 16807293 18210153 16540662 16935385 17978847 16569478 3084413 19208518 20727157 19701751 19171122 20514400
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.8116924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 18.8115289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 18.8116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.8117173139 1701930 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.8117997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.537296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4920419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.4916033868
MESH:D006332 Cardiomegaly Ethanol 6.2719332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2718850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7815710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.0916332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7718974383
MESH:D002386 Cataract Trinitrotoluene 3.6914694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 18.847505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.841399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.8412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.8417174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.8418566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.954080065
MESH:D002637 Chest Pain Omeprazole 4.7915447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.6219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.6216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.6218291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.349022650 19486331
MESH:D002779 Cholestasis Cyclosporine 17.3419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.3416105132 15861022 16919318 11677210 17681005 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 17.3419176532
MESH:D002971 Cleft Lip Ethanol 3.4215513904
MESH:D002972 Cleft Palate Ethanol 9.2115513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.2112621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate triadimefon 9.2116781842
MESH:D003110 Colonic Neoplasms Genistein 2.2317182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.4114669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.4115095906
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7510194807 15451039 15451040 19302082 15513904 11198716 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities triadimefon 3.7516875885 15834900
MESH:D003490 Cyanosis Trinitrotoluene 4.6218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5112868966 2524372 18759878 8970840 8156756 14531868 11906362 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.213621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 9.5919647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.5920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.5916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1519279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 20.519022650 8291058 18692083 1440618 18289764 9653073 7440962 6679447 16192314 9328219 6482804 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury Amiodarone 20.5115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.5119107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 20.518172417
MESH:D056486 Drug-Induced Liver Injury Ethanol 20.5111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.5120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 20.5112963478
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 20.5121346803 18551238
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0417151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.8516707586
MESH:D004421 Dystonia Phenobarbital 3.721851702
MESH:D004487 Edema pirinixic acid 5.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9012538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.2816402032
MESH:D016889 Endometrial Neoplasms Estradiol 6.8311473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 6.8311473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7610568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.803659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.563922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.286401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.713659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.723581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.7216530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.7217016578
MESH:D004938 Esophageal Neoplasms Ethanol 9.7216704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7811564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4016456712
MESH:D005234 Fatty Liver Amiodarone 32.7114986274
MESH:D005234 Fatty Liver Clofibrate 32.7119224547
MESH:D005234 Fatty Liver Cyclosporine 32.7119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 32.7120387270 21071580
MESH:D005234 Fatty Liver Ethanol 32.7119236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 32.7115345470
MESH:D005234 Fatty Liver pirinixic acid 32.7120131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3517920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9916946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.706705139
MESH:D005355 Fibrosis Cyclosporine 7.4712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4720067830
MESH:D005756 Gastritis Ethanol 4.3815046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.918708960
MESH:D005909 Glioblastoma Genistein 3.0616598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.757505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3018665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.476705139
MESH:D006505 Hepatitis Thioacetamide 8.4716456712
MESH:D006529 Hepatomegaly Amiodarone 42.2215265979
MESH:D006529 Hepatomegaly Phenobarbital 42.2216109766
MESH:D006529 Hepatomegaly pirinixic acid 42.2216221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly propiconazole 42.2217178689 17178688
MESH:D006529 Hepatomegaly systhane 42.2217178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 42.2215340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 42.2217178688 17178689
MESH:D006529 Hepatomegaly Trinitrotoluene 42.2215817613
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7315340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 3.4818783367
MESH:D006937 Hypercholesterolemia Amiodarone 3.608137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.9220558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6415034207
MESH:D006973 Hypertension Cyclosporine 4.5410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.6018020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.6018031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2117937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.2112150543
MESH:D007249 Inflammation Diethylnitrosamine 4.3618785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.5216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.5216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.708074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 15.7215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.7216580747
MESH:D007569 Jaw Abnormalities triadimefon 15.7215992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.3418776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 5.3415618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.926582329
MESH:D007680 Kidney Neoplasms Cyclosporine 10.9212371664
MESH:D007680 Kidney Neoplasms Estradiol 10.9215610895
MESH:D007859 Learning Disorders Ethanol 3.9115451040
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8519248655
MESH:D007938 Leukemia Genistein 2.8717468513 18980019
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5917676605
MESH:D008064 Lipidoses Amiodarone 3.2915342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.0918522880 19638242 18665156 18407596 20032147
MESH:D008103 Liver Cirrhosis Ethanol 10.0915289165
MESH:D008103 Liver Cirrhosis Phenobarbital 10.0921047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7818295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.009327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 10.2616627068 15161499 17201889 17198567 15369754 16570917 15383259 14568256 14726149 16169303 16270385 17534399 17666798 15577212 15366600 18629640 17640959 15504291 15763062 18637143 18095165 15723089 15492853 15744066 15086199 18567088 18371158 15793283 18210741 14643895 15339415 15571005 15298665 15591649 18672772 16603200 15479170 15798949 15942678 17203207 17196135 17724770 17719030 18239293 15842777 16009107 15733078 12925901 15864749 16544323 18364076 14709902 15081153 15138612 17036385 16042886 15099470 17348192 17432682 15067225 18237412 17881167 17465448 12918455 14659978
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 10.2618166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.2617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 10.2615465738 15095483 12679928 17355460 17127702 18380797 11481614 15316131 17050028 16126171 18416461 15078482 16098781 16343077 15334695 18458672 16489207 15288472 12175628 11682029 12531686 18032466 15075984 15158331 15288473 18295389 18615449 17629604 15362042 18395095 16511523 15474484 18263696 17292413 12557150 11172339 14739098 15716488 16097051 18031379 12085344 12891558 18606216 16248980 10677585
MESH:D008107 Liver Diseases Diethylnitrosamine 11.6417034775
MESH:D008107 Liver Diseases Phenobarbital 11.6419363144
MESH:D008107 Liver Diseases propiconazole 11.6419363144
MESH:D008107 Liver Diseases Thioacetamide 11.6416337175 15158337 18374380
MESH:D008107 Liver Diseases triadimefon 11.6419363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3517207112 17347304
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.1817457977
MESH:D017114 Liver Failure, Acute Thioacetamide 9.1815633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms Aflatoxin B1 31.809163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 31.8020195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 31.8017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.8020501860 19850985 19642983 9163691 19551842 20434301 21071580 19996281 18978307 19833225 19090486 19255062 20118626 15885732 2422723 19256749 2862719 19427195 20137499 20583210 19690152 19073162 18644402 16942905 12112319 20405173 19426721 20492335 20452335 10737359 12771043 21167192 15175105 21047994 19812893 18977376 20101389 18648771 21278145 19294768 19499222 19254457 19638242 18754104
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 31.803113478 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 31.8019482888 19812893 19073162 8742319 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 31.8020007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 31.8019028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.8016984957
MESH:D008113 Liver Neoplasms triadimefon 31.8019028983
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 34.67598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 34.678603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 34.6719009564 19126423 18775883 18164116 18544905 17854601 16267830 21159647 18079962 18253720 9362446 18282651 19539802 16842330 17174075 18308698 19004024 18093689 2563599 17942915 3124819 19519916
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 34.671848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 34.671399818 6150874 17172636 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental propiconazole 34.6717178689
MESH:D008114 Liver Neoplasms, Experimental systhane 34.6717178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 34.6712151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 34.6717178689
MESH:D008133 Long QT Syndrome Amiodarone 3.3511989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.1712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1618516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.1414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.1420464547 20064080 18569708 6695378 18816296 20869020 20135361 17053015 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.1420970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 6.1416061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.4317203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.4312929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.1719453300
MESH:D008569 Memory Disorders Ethanol 3.8915451040 18411066
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4716801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009181 Mycoses Amiodarone 4.5917974566 12754197
MESH:D009203 Myocardial Infarction Genistein 5.2417141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.8116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.8116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1617484760
MESH:D009336 Necrosis Trinitrotoluene 4.4618551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.273581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.273581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.3111141357
MESH:D009369 Neoplasms pirinixic acid 4.3117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0318481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 14.6516427766 11399458
MESH:D009421 Nervous System Malformations Genistein 14.6516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.6514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.716679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.639802331
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.324026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 8.3217852074 14694615 12819281
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.703988306
MESH:D010018 Osteomalacia Phenobarbital 4.0517016548
MESH:D010024 Osteoporosis Genistein 3.0619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8016169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.5619401270
MESH:D010051 Ovarian Neoplasms Genistein 4.5619005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.0016540662
MESH:D010190 Pancreatic Neoplasms Ethanol 8.0012384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.0016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.187296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.156228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.7712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.772563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8811399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.6416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6415256057 16925846 15378649
MESH:D011537 Pruritus Ethinyl Estradiol 3.0015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.1812752131
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7311597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.153692021
MESH:D012640 Seizures Ethanol 8.809754883
MESH:D012640 Seizures Phenobarbital 8.803137016 16876388 11442880 4039156
MESH:D012640 Seizures Trinitrotoluene 8.8018551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.516407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7718724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.9810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6316709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9512587719
MESH:D013163 Splenomegaly Trinitrotoluene 4.9015817613
MESH:D013272 Stomach Diseases Omeprazole 4.3018545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4818456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.4816033868
MESH:D013274 Stomach Neoplasms Ethanol 4.4818456281
MESH:D013276 Stomach Ulcer Amiodarone 10.6118087811
MESH:D013276 Stomach Ulcer Ethanol 10.6116755016 17189318 17918041 9562338 11906479 9211565
MESH:D013276 Stomach Ulcer Omeprazole 10.6116755016 18237397 11906479 17977527 15991576 10750652
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.999754883
MESH:D013610 Tachycardia Amiodarone 3.9911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8919225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013959 Thyroid Diseases Amiodarone 11.0019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 20.016587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 20.017505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 20.011399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 20.0115710170
MESH:D013964 Thyroid Neoplasms triadimefon 20.0117178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.5619584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8817467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.558074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.5517053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0014692618
MESH:D014605 Uveitis Cyclosporine 3.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D014689 Venous Insufficiency coumarin 5.4612708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2615869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1317120751
Pathway ID Pathway Name
KEGG:00630 Glyoxylate and dicarboxylate metabolism
KEGG:01100 Metabolic pathways
KEGG:04146 Peroxisome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03247 - Riboflavin Monophosphate Vitamin B Complex
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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