AutismKB 2.0

Annotation Detail for GPN3


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Basic Information Top
Gene Symbol:GPN3 ( ATPBD1C,MGC14560,MGC32810 )
Gene Full Name: GPN-loop GTPase 3
Band: 12q24.11
Quick LinksEntrez ID:51184; OMIM: NA; Uniprot ID:GPN3_HUMAN; ENSEMBL ID: ENSG00000111231; HGNC ID: 30186
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of GPN3 mRNAdecreases expression 20458559
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GPN3 mRNAaffects binding|decreases expression|increases activity 19710929
D014810 Vitamin E Vitamin E results in decreased expression of GPN3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.6516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.6519483382
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.8611589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.5816050911
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9815553829 16217749 11135700 14691202 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.7419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5712490120
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.7712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.8110525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.8119769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.6315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:C538011 Eales disease Vitamin E 5.579068938
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3912903497
MESH:D005234 Fatty Liver arsenic trioxide 9.3715073043
MESH:D005234 Fatty Liver pirinixic acid 9.3720131406 19236843
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.8516904648
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1816080930
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6419176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.8414716179
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007251 Influenza, Human Vitamin E 5.0816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007674 Kidney Diseases Vitamin E 3.0312488133
MESH:D007938 Leukemia arsenic trioxide 3.0115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.0516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.2419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916467208 20471514 17050201 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4819075265 12679006 16823087 19225113 17712046 16891316 17107899 15336539 11468182 11161223 16112521 17217047 19642359 15213294 12712474 16330433 17649720 16331271 15748426 12018890 9834237 16966277 19035177 15622746 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.9416882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4816169303
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9214682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.9220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6915213294
MESH:D008171 Lung Diseases Vitamin E 3.4516863852
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6311798837 19825857
MESH:D008175 Lung Neoplasms Vitamin E 2.6311062179
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4119417148 19549372 14977855 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3616105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.5416624393
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3810525206
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5112452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6415580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6919927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2115084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.5416646077
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.8816517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.4319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.7015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6120435036 12973940 12845720 11780464
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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