AutismKB 2.0

Annotation Detail for CHMP1A


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Basic Information Top
Gene Symbol:CHMP1A ( CHMP1,KIAA0047,PCOLN3,PRSM1,Vps46A )
Gene Full Name: chromatin modifying protein 1A
Band: 16q24.3
Quick LinksEntrez ID:5119; OMIM: 164010; Uniprot ID:CHM1A_HUMAN; ENSEMBL ID: ENSG00000131165; HGNC ID: 8740
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CHMP1A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CHMP1A mRNAaffects expression 17562736
D012643 Selenium Selenium results in increased expression of CHMP1A mRNAincreases expression 19244175
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of CHMP1A mRNAincreases expression 18514395
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 3.7618855134
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7517906064 16781746 11834606 19416960 17522070 18071297 16227642 12705907 16109766 18713872 15968718 11461765 2444490 12153990 11421492 14725611 19420014 17562736 19923254 19370779 10915739 16485898 14986274 11529661 16081117 12392966 11287661 12594235 15619225 16393943 19739265 12540782 19085960 11739529 16177239 14550746 12958197 19164858 10663392 11743745 10774834
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006333 Heart Failure Selenium 3.2917162251
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007251 Influenza, Human Selenium 4.9216624496
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3216705839
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 12969438 11587558 16611625 12587719 19784758 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008325 Mammary Neoplasms, Experimental Selenium 7.4315318939
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 7.4315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8216049721 12819281
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.4116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
KEGG:04144 Endocytosis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018