AutismKB 2.0

Annotation Detail for CKLF


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Basic Information Top
Gene Symbol:CKLF ( C32,CKLF1,CKLF2,CKLF3,CKLF4,UCK-1 )
Gene Full Name: chemokine-like factor
Band: 16q21
Quick LinksEntrez ID:51192; OMIM: NA; Uniprot ID:CKLF_HUMAN; ENSEMBL ID: ENSG00000217555; HGNC ID: 13253
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CKLF mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CKLF mRNAaffects expression 17562736
C103505 AM 251 AM 251 results in increased expression of CKLF mRNAincreases expression 16500647
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CKLF mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of CKLF mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CKLF mRNAincreases expression 15834898
D008942 Mitoxantrone CKLF protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in increased expression of CKLF mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 14.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.3817333356 16105132 17110522 11677210 17681005 15861022 16919318
MESH:D002779 Cholestasis pirinixic acid 14.3819176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9116227642 19739265 19416960 11743745 11461765 18713872 18071297 12540782 11834606 14550746 10915739 2444490 11421492 11529661 17522070 19164858 16781746 12153990 14725611 19923254 14986274 12594235 12705907 19420014 15968718 11739529 16177239 10663392 12958197 11287661 16081117 17906064 16393943 15619225 10774834 19085960 16485898 17562736 19370779 12392966 16109766
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D005234 Fatty Liver Cyclosporine 14.4619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.4615345470
MESH:D005234 Fatty Liver pirinixic acid 14.4619236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006331 Heart Diseases Mitoxantrone 4.3116019553
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8718172266
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19460945 12587719 19014921 16610002 12969438 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8915890375 16377806 20007298
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009369 Neoplasms Mitoxantrone 5.6316640825
MESH:D009369 Neoplasms pirinixic acid 5.6317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D010146 Pain Acetaminophen 7.7716870215
MESH:D010146 Pain AM 251 7.7718987195
MESH:D010190 Pancreatic Neoplasms AM 251 3.9116500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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