AutismKB 2.0

Annotation Detail for CPA4


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Basic Information Top
Gene Symbol:CPA4 ( CPA3 )
Gene Full Name: carboxypeptidase A4
Band: 7q32.2
Quick LinksEntrez ID:51200; OMIM: 607635; Uniprot ID:CBPA4_HUMAN; ENSEMBL ID: ENSG00000128510; HGNC ID: 15740
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CPA4 mRNAincreases expression 20382639
D002117 Calcitriol Calcitriol results in decreased expression of CPA4 mRNAdecreases expression 16002434
D005472 Fluorouracil Fluorouracil results in decreased expression of CPA4 mRNAdecreases expression 16510598
D014415 Tunicamycin Tunicamycin results in increased expression of CPA4 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.5017638652
MESH:D000740 Anemia Fluorouracil 4.1117963324 15504547 16511603
MESH:D001943 Breast Neoplasms Calcitriol 2.3511237771
MESH:D001943 Breast Neoplasms Fluorouracil 2.3516595493 18608205 16110121 16557594 18357371 19217205 15136595
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1217971768 18930000 16332177 17088986 16799960 17045692
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1611237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.1616757204 17066447 18986760 16280240
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817169374 15001691 18772588 16340194 17172411 16510598 17287894 17725105 17016597 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017016601 17695437 18949393 15148649 18448328 18802399 17255274 18383874 16391804 17454858 17594712 16303861 18288408 18509181 15289873 16524972 14970324 16282729 16331619 20501625 17094418 17401013
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.4415138306
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7815173087 16481741 17638652 16337965 16785472
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6418337622 15102660 15162350
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6516985049
MESH:D008113 Liver Neoplasms Fluorouracil 2.6018383874 17045692 16603448 15113037
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9416757204 18986760
MESH:D009369 Neoplasms Fluorouracil 2.7718600527 18239605 16928823
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7715113037 16500647 19003803 16929163
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.4115572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3616644109 18247401 15754350 16289102 12479363
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3818286688 18722050 15538739 16160472
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019084572 18396642 15786421 16424979 17172411 17522103 16951190 17498489 18567086 19015929
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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