AutismKB 2.0

Annotation Detail for PCP4


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Basic Information Top
Gene Symbol:PCP4 ( PEP-19 )
Gene Full Name: Purkinje cell protein 4
Band: 21q22.2
Quick LinksEntrez ID:5121; OMIM: 601629; Uniprot ID:PCP4_HUMAN; ENSEMBL ID: ENSG00000183036; HGNC ID: 8742
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PCP4 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of PCP4 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of PCP4 mRNA]affects reaction|decreases expression 18929588
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PCP4 mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A results in increased expression of PCP4 mRNAincreases expression 16474171
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PCP4 mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCP4 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of PCP4 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PCP4 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PCP4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCP4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PCP4 mRNAincreases expression 15576828
12655037
D005480 Flurbiprofen Flurbiprofen results in decreased expression of PCP4 mRNAdecreases expression 16949054
D019833 Genistein Genistein results in increased expression of PCP4 mRNAincreases expression 16474171
D007657 Ketone Bodies Ketone Bodies results in increased expression of PCP4 mRNAincreases expression 16807920
D010656 Phenylephrine Phenylephrine results in decreased expression of PCP4 mRNAdecreases expression 18158353
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of PCP4 mRNAincreases expression 16474171
D012643 Selenium Selenium results in decreased expression of PCP4 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCP4 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PCP4 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCP4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PCP4 mRNAincreases expression 15591033
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Estradiol 7.1511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1514692618
MESH:D000230 Adenocarcinoma Genistein 7.1511473722
MESH:D000236 Adenoma beta-Naphthoflavone 6.9819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3316434500 18056438 19061943 17620307 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3316835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 5.1210680582
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1617460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D001919 Bradycardia Phenylephrine 4.6315306635
MESH:D001943 Breast Neoplasms bisphenol A 2.3517123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3517474063
MESH:D001943 Breast Neoplasms Estradiol 2.3517289903 19861407 12948864 14630087 17018787 16675129 17261762 18497071
MESH:D001943 Breast Neoplasms Genistein 2.3517200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6718210153 20524982 18788625 20432363 19519916 18691550 19052882 18056438 19701751 16935385 20727157 19208518 16878318 16540662 20084675 18971187 17761372 19107877 17138121 19822196 19394651 18665156 16807293 16698587 19171122 16681979 19335982 21159647 17978847 20512989 19539802 20214788 16502159 17428255 20514400 20101231 3084413 16569478 18393292 18494052 18785209 17055752 3581430 19383236 16288022 17162532 17173139 19418558 16328049 10737359 18506893 16830150 19919837 20935162 11831363 16779866 10672840 18978308 20007298
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D006332 Cardiomegaly Phenylephrine 6.9815728586 16170337 17124262 17287366 11179087 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.827505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9117110522 16105132 15861022 17681005 11677210 16919318 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 12621046 16354765 15340226 15668235
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms arsenite 4.0115037631
MESH:D003110 Colonic Neoplasms Genistein 4.0117182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7516140633
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.1816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.6218566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 7.6211473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver arsenite 13.5118296743
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.5115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis arsenite 9.0618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0620067830
MESH:D005909 Glioblastoma Genistein 3.2916598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 15340226 8697196 16959395 16354765
MESH:D006973 Hypertension Phenylephrine 5.3712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6112791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Diethylnitrosamine 8.6218785209
MESH:D007249 Inflammation Flurbiprofen 8.6211099482
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6212200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance bisphenol A 7.5516393666
MESH:D007333 Insulin Resistance Estradiol 7.5516393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Estradiol 2.6115618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D007938 Leukemia Genistein 3.0518980019 17468513
MESH:D008103 Liver Cirrhosis arsenite 6.9318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9318407596 18665156 18522880 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.5719389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5718754104 19551842 19499222 20583210 19638242 18978307 20452335 20434301 19294768 21167192 19426721 19833225 21278145 2862719 19812893 15885732 21047994 19996281 19690152 2422723 20405173 20101389 10737359 19090486 12112319 15175105 18644402 19073162 20137499 19254457 20492335 20501860 12771043 19642983 9163691 20118626 21071580 19256749 16942905 18648771 19427195 19850985 18977376 19255062
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.4618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.4619519916 18775883 2563599 18079962 18308698 19539802 18253720 18544905 17174075 3124819 19004024 19009564 9362446 18093689 21159647 17942915 19126423 16267830 17854601 18282651 16842330 18164116
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 14.461423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4612151625
MESH:D008175 Lung Neoplasms arsenite 3.4816809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4821163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.2011807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.2014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.2015318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6517141266
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009389 Neovascularization, Pathologic arsenite 10.4315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 10.4317289903
MESH:D009421 Nervous System Malformations bisphenol A 24.0211399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 24.0211399458 16427766
MESH:D009421 Nervous System Malformations Genistein 24.0216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.0214600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9519005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4116702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.7910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7911896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.7420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.7420887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 1.9017409433
MESH:D011471 Prostatic Neoplasms Genistein 1.9016925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.9015721890
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012852 Sinusitis Phenylephrine 4.787327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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