AutismKB 2.0

Annotation Detail for PIGP


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Basic Information Top
Gene Symbol:PIGP ( DCRC,DCRC-S,DSCR5,DSRC )
Gene Full Name: phosphatidylinositol glycan anchor biosynthesis, class P
Band: 21q22.13
Quick LinksEntrez ID:51227; OMIM: 605938; Uniprot ID:PIGP_HUMAN; ENSEMBL ID: ENSG00000185808; HGNC ID: 3046
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of proteins
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PIGP mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PIGP mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of PIGP mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of PIGP mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of PIGP mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PIGP mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PIGP mRNAaffects cotreatment|affects expression 17602206
D005001 Ethionine Ethionine affects the expression of PIGP mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of PIGP mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of PIGP mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid affects the expression of PIGP mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of PIGP mRNAaffects expression 19483382
D012643 Selenium Selenium results in decreased expression of PIGP mRNAdecreases expression 19244175
D013853 Thioacetamide Thioacetamide affects the expression of PIGP mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.823712494
MESH:D000236 Adenoma Diethylnitrosamine 6.826695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4916434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4916434500
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8818057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.9619698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.5019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.5019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.5019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.5019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.5019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.5019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.5019483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.5019483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.023581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.023084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 9.021701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.023581430 3084413 16698587 17055752 20935162 20007298 19383236 17761372 20512989 19171122 18691550 19208518 18978308 19919837 17428255 17173139 18665156 19539802 19394651 20524982 16540662 17138121 20727157 21159647 16807293 16569478 19519916 16328049 19107877 18506893 18971187 18393292 20514400 16502159 20432363 16935385 18056438 20214788 20101231 17978847 19335982 19052882 20084675 10672840 18494052 18210153 19418558 16779866 16830150 11831363 16681979 19701751 17162532 16288022 18788625 18785209 16878318 10737359 19822196
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 9.0217997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2018974383
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.617505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.611399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.6117174075 21159647 7505956 2727394
MESH:D002637 Chest Pain Omeprazole 5.2415447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9819052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.9818291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.049022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.0419176532
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9011906362 8156756 14531868 11298694 2524372 8970840 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.589022650 16192314 18692083 6482804 8291058 7440962 18289764 6679447 9328219 18648102 9653073 1440618 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5810663392 12540782 18713872 19416960 2444490 14725611 12392966 16781746 19923254 11739529 14986274 19085960 15619225 18071297 16393943 11461765 17522070 16177239 12594235 16227642 12153990 11743745 16485898 10915739 10774834 11287661 12958197 14550746 19420014 15968718 11834606 16081117 19370779 19739265 19164858 16109766 17562736 17906064 11421492 12705907 11529661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.5815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5819107877
MESH:D056486 Drug-Induced Liver Injury Selenium 15.5815131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.5812963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.4216613094 21218061 15991576 17151854
MESH:D050171 Dyslipidemias Clofibrate 4.1216707586
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005218 Fat Necrosis Thioacetamide 5.8516456712
MESH:D005234 Fatty Liver Amiodarone 19.5214986274
MESH:D005234 Fatty Liver Clofibrate 19.5219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.5220387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 19.5219236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6515929193 18665440 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.776705139
MESH:D006505 Hepatitis Thioacetamide 9.7716456712
MESH:D006529 Hepatomegaly Amiodarone 8.9315265979
MESH:D006529 Hepatomegaly pirinixic acid 8.9319176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.958137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D007037 Hypothyroidism Amiodarone 11.9617991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.9618031379 8137927
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.036582329
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1619248655
MESH:D008064 Lipidoses Amiodarone 3.5715342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718522880 18665156 20032147 19638242 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5718031379 16511523 17292413 18395095 15474484 18416461 17050028 15362042 11682029 12891558 17629604 18606216 18458672 12679928 11172339 15075984 15716488 15288473 15078482 12175628 15288472 10677585 16343077 15334695 18380797 14739098 15095483 16489207 15316131 15158331 18295389 18615449 16126171 11481614 18263696 17355460 17127702 15465738 16248980 12557150 18032466 16097051 16098781 12531686 12085344
MESH:D008107 Liver Diseases Acetaminophen 6.6716610002 19014921 12969438 19460945 16611625 19784758 11587558 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6717034775
MESH:D008107 Liver Diseases Thioacetamide 6.6718374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8916871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 9.8917276928 15633222 15313186 12479984
MESH:D008113 Liver Neoplasms Clofibric Acid 7.6417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6419690152 19255062 19499222 19256749 19812893 15885732 19254457 20118626 19426721 20405173 20137499 19642983 20101389 19996281 21278145 18978307 16942905 19294768 18977376 10737359 12112319 21167192 19427195 19090486 18648771 19850985 18754104 19551842 19073162 2862719 12771043 21071580 19638242 21047994 20452335 20583210 18644402 2422723 15175105 20492335 9163691 19833225 20501860 20434301
MESH:D008113 Liver Neoplasms pirinixic acid 7.6415890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.08598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0819539802 19126423 18093689 18544905 17942915 18164116 16267830 18079962 2563599 18253720 19519916 18775883 21159647 18308698 9362446 19004024 17854601 19009564 17174075 18282651 16842330 3124819
MESH:D008133 Long QT Syndrome Amiodarone 3.6417391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6118516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009181 Mycoses Amiodarone 5.0417974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.803581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.803581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.049802331
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8811597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2018724381
MESH:D013272 Stomach Diseases Omeprazole 4.7318545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 7.8518087811
MESH:D013276 Stomach Ulcer Omeprazole 7.8515991576 18237397 11906479 16755016 17977527 10750652
MESH:D013610 Tachycardia Amiodarone 4.3811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2819225199
MESH:D013959 Thyroid Diseases Amiodarone 4.8919731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.413712494 6587162 1399818 7505956 6582329
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.417505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 12.4115710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9618020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3117467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.308074119
MESH:D014581 Urticaria Acetaminophen 3.0610982225
Pathway ID Pathway Name
KEGG:00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27498
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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