AutismKB 2.0

Annotation Detail for NT5C3


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Basic Information Top
Gene Symbol:NT5C3 ( MGC27337,MGC87109,MGC87828,P5'N-1,PN-I,PSN1,UMPH,UMPH1,cN-III )
Gene Full Name: 5'-nucleotidase, cytosolic III
Band: 7p14.3
Quick LinksEntrez ID:51251; OMIM: 606224; Uniprot ID:5NT3_HUMAN; ENSEMBL ID: ENSG00000122643; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6353purine nucleotides degradation II (aerobic)
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
No data
No data
Related Diseases/Disorders Top
No data
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No data
Desease Name
Anemia, hemolytic, due to UMPH1 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NT5C3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of NT5C3 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of NT5C3 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NT5C3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NT5C3 mRNAaffects cotreatment|increases expression 17942748
D007854 Lead Lead results in decreased activity of NT5C3 proteindecreases activity 16672222
D007854 Lead Lead binds to and results in decreased activity of NT5C3 proteinaffects binding|decreases activity 16672222
D008274 Magnesium Magnesium binds to NT5C3 proteinaffects binding 16672222
C029938 nickel sulfate nickel sulfate results in decreased expression of NT5C3 mRNAdecreases expression 16780908
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NT5C3 mRNAincreases expression 15716485
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NT5C3 mRNAaffects cotreatment|increases expression 17942748
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.089612607
MESH:D055371 Acute Lung Injury nickel sulfate 4.5319131640 16100012 12718980 11954676
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma Magnesium 4.6517823441
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000746 Anemia, Hemolytic, Congenital Nonspherocytic marker/mechanism 16672222
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 2.4418445737
MESH:D001321 Autistic Disorder Magnesium 2.4416846101
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0217110522 16919318 15861022 16105132 17333356 11677210 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 8697196 16354765 12621046 15668235
MESH:D003111 Colonic Polyps Magnesium 6.2917823441
MESH:D015179 Colorectal Neoplasms Magnesium 3.4517823441
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Lead 3.0419769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.0420055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003704 Dementia Lead 5.4616140633
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.9316823706 11298694 16780908
MESH:D002658 Developmental Disabilities Magnesium 5.0416846101
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3919164858 16177239 16081117 11461765 12153990 14986274 16393943 10915739 10663392 12540782 15619225 19085960 2444490 17522070 19370779 12705907 18713872 11743745 16109766 19739265 19420014 18071297 16485898 11287661 17562736 14725611 12594235 12958197 19923254 15968718 12392966 11421492 10774834 16227642 11529661 17906064 19416960 11834606 14550746 16781746 11739529
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7411462148
MESH:D004362 Drug Toxicity Zidovudine 8.7415040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D020329 Essential Tremor Lead 6.2114594619 18007985
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6615345470
MESH:D005234 Fatty Liver Zidovudine 8.6618299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005317 Fetal Growth Retardation Lead 5.7819769572
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.9312579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 12621046 15340226
MESH:D015658 HIV Infections Zidovudine 3.5911363243 20032539 11698656 11141242 17358032
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16354765 18606429 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.5917937319
MESH:D007248 Infertility, Male Lead 7.5916780224
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.5316705839
MESH:D007680 Kidney Neoplasms Zidovudine 13.5312579204
MESH:D007855 Lead Poisoning Lead 6.2116700817
MESH:D007859 Learning Disorders Lead 5.4416384672
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.6220370541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 11587558 12969438 16611625 19014921 16610002 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.597678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.142876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5711884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 2.5718800350
MESH:D008275 Magnesium Deficiency Magnesium 6.7317823441
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008569 Memory Disorders Lead 5.4016384672 17263510
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1617358032
MESH:D008881 Migraine Disorders Magnesium 4.9118803445
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Lead 10.9516384672
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.9511399792 11896295 11118676 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014202 Tremor Lead 5.8121145352
OMIM:266120 URIDINE 5-PRIME MONOPHOSPHATE HYDROLASE DEFICIENCY, HEMOLYTIC ANEMIA DUE TO marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014625 Vaginal Neoplasms Zidovudine 5.0212579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00760 Nicotinate and nicotinamide metabolism
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31802
    • Releated gene ID Related gene Name
    PA31802NT5C3
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    Releated drug ID Related drug Name
    PA449177cytarabine
    PA130230921uridine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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