AutismKB 2.0

Annotation Detail for MARCH2


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Basic Information Top
Gene Symbol:MARCH2 ( MARCH-II,RNF172 )
Gene Full Name: membrane-associated ring finger (C3HC4) 2
Band: 19p13.2
Quick LinksEntrez ID:51257; OMIM: 613332; Uniprot ID:MARH2_HUMAN; ENSEMBL ID: ENSG00000099785; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of MARCH2 mRNAincreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MARCH2 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MARCH2 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MARCH2 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of MARCH2 mRNAdecreases expression 20106945
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of MARCH2 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of MARCH2 mRNA]affects expression|affects reaction 16166738
D012643 Selenium Selenium results in increased expression of MARCH2 mRNAincreases expression 19244175
D014415 Tunicamycin Tunicamycin results in decreased expression of MARCH2 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Nickel 4.8416166738
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4520146248 17474063
MESH:D001943 Breast Neoplasms Nickel 2.4515986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9711135700 16217749 14691202 15553829 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.2517244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.892952479
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2315131321
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5216530937
MESH:D005234 Fatty Liver arsenic trioxide 8.5715073043
MESH:D005234 Fatty Liver Cyclosporine 8.5719224547
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D015658 HIV Infections Nickel 3.9317263646
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation Nickel 3.5316166738
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 16467208 20471514 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3619075265 19225113 19642359 16823087 9834237 15336539 16112521 11161223 12712474 17217047 15213294 16966277 16330433 16331271 17712046 15748426 17649720 12679006 17107899 12018890 11468182 15622746 19035177 17869043 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8220195826 21137059
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8720377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4719825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4720869020 18816296 20135361 18569708 6695378 20464547 18520028 17053015 20064080
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719417148 15949261 19549372 11468182 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5915580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1217292933
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0419755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.048532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3111780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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