AutismKB 2.0

Annotation Detail for PIPOX


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Basic Information Top
Gene Symbol:PIPOX ( LPIPOX )
Gene Full Name: pipecolic acid oxidase
Band: 17q11.2
Quick LinksEntrez ID:51268; OMIM: NA; Uniprot ID:SOX_HUMAN; ENSEMBL ID: ENSG00000179761; HGNC ID: 17804
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-3661glycine betaine degradation
PWY-5283lysine degradation V
Pathway IDPathway Name
hsa00310Lysine degradation
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa00260Glycine, serine and threonine metabolism
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PIPOX mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PIPOX proteinaffects expression 20106945
D019817 Benzoic Acid Benzoic Acid inhibits the reaction [PIPOX protein results in increased metabolism of pipecolic acid]decreases reaction|increases metabolic processing 9045710
D019817 Benzoic Acid Benzoic Acid results in decreased activity of PIPOX proteindecreases activity 9045710
D016572 Cyclosporine Cyclosporine results in decreased expression of PIPOX mRNAdecreases expression 20106945
C008919 delta-1-piperidine-6-carboxylic acid PIPOX protein results in increased chemical synthesis of delta-1-piperidine-6-carboxylic acidincreases chemical synthesis 10772957
C008919 delta-1-piperidine-6-carboxylic acid PIPOX protein results in increased chemical synthesis of delta-1-piperidine-6-carboxylic acidincreases chemical synthesis 10772957
D004958 Estradiol Estradiol results in decreased expression of PIPOX mRNAdecreases expression 20106945
C056933 fumonisin B1 fumonisin B1 results in decreased expression of PIPOX mRNAdecreases expression 16221962
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of PIPOX mRNAincreases expression 16966085
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PIPOX mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PIPOX mRNAdecreases expression 19482888
C031345 pipecolic acid PIPOX protein results in increased oxidation of and results in increased degradation of pipecolic acidincreases degradation|increases oxidation 10642506
C031345 pipecolic acid PIPOX protein results in increased oxidation of pipecolic acidincreases oxidation 10772957
C031345 pipecolic acid Benzoic Acid inhibits the reaction [PIPOX protein results in increased metabolism of pipecolic acid]decreases reaction|increases metabolic processing 9045710
C031345 pipecolic acid PIPOX protein results in increased oxidation of pipecolic acidincreases oxidation 9045710
C031345 pipecolic acid PIPOX protein results in increased oxidation of pipecolic acidincreases oxidation 10772957
C006253 pirinixic acid pirinixic acid results in decreased expression of PIPOX mRNAdecreases expression 17950772
16221962
15375163
C066075 vanadium pentoxide vanadium pentoxide results in increased expression of PIPOX mRNAincreases expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6416434500
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Estradiol 2.1317289903 17018787 14630087 19861407 12948864 17261762 18497071 16675129
MESH:D001991 Bronchitis vanadium pentoxide 6.4117459161
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6917173139 20007298 1701930 20935162 6705139
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D003704 Dementia Methylmercury Compounds 5.1016140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1616781746 2444490 16227642 18071297 14725611 10915739 11834606 14550746 16109766 11739529 15968718 18713872 10774834 17906064 11421492 12540782 17522070 11287661 16081117 12594235 12392966 19164858 12705907 15619225 19739265 11743745 19085960 19420014 19370779 19923254 14986274 11529661 17562736 10663392 11461765 12153990 12958197 16485898 19416960 16177239 16393943
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 4.1616221962
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0518566989 11473722 19148513
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9320131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.2812168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly fumonisin B1 15.4116221962
MESH:D006529 Hepatomegaly Phenobarbital 15.4116109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4118467677 19176532 19772884 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007333 Insulin Resistance Estradiol 7.4316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.3318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.3315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5815610895
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9521047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008107 Liver Diseases Acetaminophen 4.0111587558 19460945 19784758 19014921 16610002 12969438 12587719 16611625
MESH:D008107 Liver Diseases Phenobarbital 4.0119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.6518177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 7.6519812893 21047994 8742319 19073162 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 7.6516377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.248603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.241399818 17172636 18308698 6150874 2563599
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.0614755239
MESH:D008175 Lung Neoplasms vanadium pentoxide 3.0612376484
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008569 Memory Disorders Methylmercury Compounds 5.0318436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009069 Movement Disorders Methylmercury Compounds 5.4418436314
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D018901 Peroxisomal Disorders marker/mechanism 10642506
MESH:D018901 Peroxisomal Disorders pipecolic acid 6.8510642506
MESH:D011230 Precancerous Conditions Cyclosporine 9.3012371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.302563599
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 5.1318436314
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012640 Seizures Phenobarbital 2.7616876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.141399818
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:00310 Lysine degradation
KEGG:01100 Metabolic pathways
KEGG:04146 Peroxisome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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