AutismKB 2.0

Annotation Detail for BFAR


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Basic Information Top
Gene Symbol:BFAR ( BAR,RNF47 )
Gene Full Name: bifunctional apoptosis regulator
Band: 16p13.12
Quick LinksEntrez ID:51283; OMIM: NA; Uniprot ID:BFAR_HUMAN; ENSEMBL ID: ENSG00000103429; HGNC ID: 17613
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of BFAR mRNAincreases expression 20458559
C006632 arsenic trioxide arsenic trioxide results in decreased expression of BFAR mRNAdecreases expression 19730151
D004642 Emodin Emodin results in decreased expression of BFAR mRNAdecreases expression 16045814
D005492 Folic Acid Folic Acid affects the expression of BFAR mRNAaffects expression 16361273
C006253 pirinixic acid pirinixic acid results in increased expression of BFAR mRNAincreases expression 17426115
18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Folic Acid 4.7516595132 16316344 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000236 Adenoma Folic Acid 4.0016963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000544 Alzheimer Disease Folic Acid 3.1117116317
MESH:D001321 Autistic Disorder Folic Acid 2.8121388746
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.4516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.4519483382
MESH:D001943 Breast Neoplasms Folic Acid 3.1316777985
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9814691202 16217749 11135700 15553829 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002318 Cardiovascular Diseases Folic Acid 4.2116755160
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D002971 Cleft Lip Folic Acid 4.1521254359
MESH:D002972 Cleft Palate Folic Acid 3.708946559 21254359
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8720501625
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8717116713 16985020 16963246 17245555 17087956
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.2016886840
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D016889 Endometrial Neoplasms Folic Acid 4.2517301261
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D017889 Exfoliation Syndrome Folic Acid 6.1216504073
MESH:D005234 Fatty Liver arsenic trioxide 9.1615073043
MESH:D005234 Fatty Liver pirinixic acid 9.1619236843 20131406
MESH:D005355 Fibrosis Emodin 5.3619474275
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Folic Acid 5.8117171786
MESH:D005901 Glaucoma Folic Acid 5.5416504073
MESH:D006330 Heart Defects, Congenital Folic Acid 3.9717286298 16524890
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5518467677 19772884 19176532 16221962
MESH:D006679 HIV Seropositivity Folic Acid 6.1217209195
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.8616395265 16397167 16865747 16755160 16433478
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 11.5212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 11.5217077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1920471514 16467208 16968895 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4615336539 16891316 12712474 16823087 15748426 12679006 17107899 17869043 16331271 19225113 17712046 15622746 16330433 17649720 9834237 17217047 19035177 15213294 19642359 11161223 16112521 12018890 11468182 16966277 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008106 Liver Cirrhosis, Experimental Emodin 2.9115288473
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.9115474484
MESH:D008107 Liver Diseases Folic Acid 3.1116877991
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8814682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.8815890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.4217718048
MESH:D019767 Maxillofacial Abnormalities Folic Acid 6.3316832597
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3819549372 11468182 14977855 19417148 15949261
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009436 Neural Tube Defects arsenic trioxide 8.4510525206
MESH:D009436 Neural Tube Defects Folic Acid 8.4517438019
MESH:D009503 Neutropenia Folic Acid 4.9716322990
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D051437 Renal Insufficiency Folic Acid 5.3415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D012559 Schizophrenia Folic Acid 2.9316641680
MESH:D012871 Skin Diseases Folic Acid 3.3218709164
MESH:D013118 Spinal Cord Diseases Folic Acid 6.1216361298
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.8617007042
MESH:D013274 Stomach Neoplasms Folic Acid 2.8617171786
MESH:D020521 Stroke Folic Acid 4.6516517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6011780464 12973940 12845720 20435036
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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