AutismKB 2.0

Annotation Detail for TLR7


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Basic Information Top
Gene Symbol:TLR7 ( - )
Gene Full Name: toll-like receptor 7
Band: Xp22.2
Quick LinksEntrez ID:51284; OMIM: 300365; Uniprot ID:TLR7_HUMAN; ENSEMBL ID: ENSG00000196664; HGNC ID: 15631
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04620Toll-like receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
No data
Pathway IDPathway Name
P00054Toll receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
fibrosis hepatitis C, chronic
Celiac Disease
IMMUNE
HIV Infections
INFECTION
Desease Name
Celiac disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016589 Astemizole Astemizole results in decreased expression of TLR7 mRNAdecreases expression 20221588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TLR7 mRNAdecreases expression 20064835
C068562 loxoribine loxoribine binds to TLR7 proteinaffects binding 15777634
C013592 mangiferin mangiferin results in decreased expression of TLR7 mRNAdecreases expression 15135318
D015735 Mifepristone Mifepristone results in decreased expression of TLR7 proteindecreases expression 17701593
D011070 Poly I-C Poly I-C results in increased expression of TLR7 mRNAincreases expression 17669408
D011374 Progesterone Progesterone results in increased expression of TLR7 mRNAincreases expression 17701593
C402365 R 848 R 848 binds to TLR7 proteinaffects binding 15851485
C402365 R 848 R 848 binds to TLR7 proteinaffects binding 15851485
C099445 S 28463 S 28463 binds to and affects the activity of TLR7 proteinaffects activity|affects binding 16361354
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TLR7 mRNAdecreases expression 18175754
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.009612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D000707 Anaphylaxis mangiferin 5.6514669257 16536907
MESH:D000799 Angioedema Astemizole 5.882883202
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001249 Asthma S 28463 4.7416361354
MESH:D050197 Atherosclerosis mangiferin 4.1718450471
MESH:D001862 Bone Resorption mangiferin 5.059881647
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1517474063 20146248
MESH:D001943 Breast Neoplasms Progesterone 2.1515562024 17614352 16175315
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003457 Cryptosporidiosis mangiferin 6.0816547730
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 4.7112093613 19028559
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 3.519881663 11315760
MESH:D003928 Diabetic Nephropathies mangiferin 4.9119706694 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D004244 Dizziness Astemizole 6.683105558
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3115131321
MESH:D004362 Drug Toxicity Zidovudine 4.1115040536
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D004715 Endometriosis Mifepristone 9.8716134523
MESH:D004715 Endometriosis Progesterone 9.8716134523
MESH:D004802 Eosinophilia Astemizole 4.971355641
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver mangiferin 9.0415975614
MESH:D005234 Fatty Liver Zidovudine 9.0418299183
MESH:D005499 Folliculitis Astemizole 6.131671328
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006331 Heart Diseases mangiferin 4.4812093613
MESH:D006402 Hematologic Diseases Zidovudine 4.8612579204
MESH:D006561 Herpes Simplex mangiferin 5.2010715843
MESH:D015658 HIV Infections Zidovudine 3.5617358032 11363243 11141242 20032539 11698656
MESH:D006946 Hyperinsulinism mangiferin 5.1111315760 9881663
MESH:D006949 Hyperlipidemias mangiferin 5.0015975614
MESH:D006967 Hypersensitivity mangiferin 4.8216536907
MESH:D007154 Immune System Diseases mangiferin 6.0816076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation mangiferin 5.8715222974
MESH:D007249 Inflammation Progesterone 5.8715869954
MESH:D007333 Insulin Resistance mangiferin 8.2311315760
MESH:D007333 Insulin Resistance Sodium Selenite 8.2314714311
MESH:D007511 Ischemia mangiferin 5.4416806951
MESH:D007674 Kidney Diseases mangiferin 4.0312093613
MESH:D007680 Kidney Neoplasms Zidovudine 3.9012579204
MESH:D007859 Learning Disorders mangiferin 5.1319182383
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5520370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 4.7215498116
MESH:D017513 Lichen Nitidus Astemizole 6.682563723
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 3.4718166357
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0820195826 21137059
MESH:D008133 Long QT Syndrome Astemizole 4.7018472280 11989578
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.7618520028 20464547 20135361 18569708 17053015 18816296 20869020 20064080 6695378
MESH:D008175 Lung Neoplasms mangiferin 3.7618816296 18520028 18569708
MESH:D008175 Lung Neoplasms Zidovudine 3.7618800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008288 Malaria Astemizole 4.8316816845
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9511408345 17203775
MESH:D008569 Memory Disorders mangiferin 5.0919182383
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0617358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009203 Myocardial Infarction mangiferin 3.9016697266 17052832 16538859 16584858 19172585
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009410 Nerve Degeneration mangiferin 4.7217433543
MESH:D009759 Nystagmus, Pathologic Astemizole 6.686135121
MESH:D010051 Ovarian Neoplasms Mifepristone 5.3316525653
MESH:D010051 Ovarian Neoplasms Progesterone 5.3316525653 17393432
MESH:D010300 Parkinson Disease mangiferin 3.7517433543
MESH:D010518 Periodontitis mangiferin 5.8219026997
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1918760546
MESH:D011833 Radiation Injuries, Experimental mangiferin 6.6215830843
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.6410822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012772 Shock, Septic mangiferin 5.4315177305
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6320155912 2093021
MESH:D013274 Stomach Neoplasms Zidovudine 2.6317696246
MESH:D013276 Stomach Ulcer mangiferin 4.4117918041
MESH:D016171 Torsades de Pointes Astemizole 5.409583453 8256756
MESH:D014235 Trichinellosis mangiferin 6.2814669257
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014581 Urticaria Astemizole 4.941683191 1976298 2568189 3097109 3080510 2885854 2565098 2147912 2859714 3134034 2883202 2568013
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9312579204
MESH:D014717 Vertigo Astemizole 6.683105558
Pathway ID Pathway Name
REACT:25035 Innate immune response mediated by toll like receptors
KEGG:05162 Measles
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38008
    • No data
    Releated disease ID Related disease Name
    PA444822Lupus Erythematosus, Systemic
    Releated drug ID Related drug Name
    PA449972imiquimod
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00724 agonist Imiquimod Antineoplastic Agents;Antiviral Agents;Adjuvants, Immunologic;Interferon Inducers
    DB01611 antagonist Hydroxychloroquine Antirheumatic Agents;Enzyme Inhibitors;Antimalarials;Dermatologic Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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