AutismKB 2.0

Annotation Detail for RASL12


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Basic Information Top
Gene Symbol:RASL12 ( RIS )
Gene Full Name: RAS-like, family 12
Band: 15q22.31
Quick LinksEntrez ID:51285; OMIM: NA; Uniprot ID:RASLC_HUMAN; ENSEMBL ID: ENSG00000103710; HGNC ID: 30289
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RASL12 mRNAaffects expression 21346803
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of RASL12 mRNAaffects cotreatment|decreases expression 17404688
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RASL12 mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of RASL12 mRNAaffects cotreatment|decreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 4.8215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Estradiol 2.1712948864 14630087 17289903 19861407 17261762 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.1716175315 17614352 15562024
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1016924424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0318566989
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0521346803 18551238
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2817692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.2211473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 4.1616134523
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5518467677 16221962 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Progesterone 2.7715869954
MESH:D007333 Insulin Resistance Estradiol 8.0116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 8.0116306350
MESH:D007674 Kidney Diseases Estradiol 2.7815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.5316705839
MESH:D007680 Kidney Neoplasms Estradiol 8.5315610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9316377806 20007298 15890375
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.8611408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.8617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009421 Nervous System Malformations Estradiol 4.1611399458 16427766
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8212819281 16049721
MESH:D010051 Ovarian Neoplasms Estradiol 5.2019401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2017393432 16525653
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D013119 Spinal Cord Injuries Progesterone 4.9116503802 15862959
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.4116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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