AutismKB 2.0

Annotation Detail for GMPR2


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Basic Information Top
Gene Symbol:GMPR2 ( MGC15084,MGC830 )
Gene Full Name: guanosine monophosphate reductase 2
Band: 14q12
Quick LinksEntrez ID:51292; OMIM: 610781; Uniprot ID:GMPR2_HUMAN; ENSEMBL ID: ENSG00000100938; HGNC ID: 4377
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
Pathway IDPathway Name
Metabolism of nucleotides
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GMPR2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GMPR2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GMPR2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GMPR2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GMPR2 mRNAdecreases expression 15336504
D004041 Dietary Fats Dietary Fats results in decreased expression of GMPR2 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of GMPR2 mRNAincreases expression 18042831
C041786 palm oil palm oil results in decreased expression of GMPR2 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in increased expression of GMPR2 mRNAincreases expression 18042831
D012643 Selenium Selenium results in increased expression of GMPR2 mRNAincreases expression 19244175
D013752 Tetracycline Tetracycline results in increased expression of GMPR2 mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.717296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.126135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3019486331 9022650
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.068970840 18759878 11298694 12868966 11906362 2524372 14531868 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.629653073 9328219 18692083 6482804 18289764 7440962 1440618 6679447 11289319 18648102 9022650 8291058 16192314
MESH:D056486 Drug-Induced Liver Injury Selenium 12.6215131321
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.6217522070
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Dietary Fats 8.8718296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Tetracycline 8.8719224547 16917069
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.426582329
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.292876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.291399818 6587162 3712494 598648
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.3218551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009395 Nephritis, Interstitial Tetracycline 5.109884423
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009765 Obesity Dietary Fats 2.3317217161 21332399 20132043 19632207 16723640 11836018 18457598 20518802 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.2316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.234026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.7511026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D017096 Prion Diseases Tetracycline 5.7010903871
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.778532709
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.043712494 6582329 1399818 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.698074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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