Annotation Detail for SLC15A3
Basic Information Top
| Gene Symbol: | SLC15A3 ( FLJ26631,OCTP,PHT2,PTR3 ) |
|---|---|
| Gene Full Name: | solute carrier family 15, member 3 |
| Band: | 11q12.2 |
| Quick Links | Entrez ID:51296; OMIM: 610408; Uniprot ID:S15A3_HUMAN; ENSEMBL ID: ENSG00000110446; HGNC ID: 18068 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| Transmembrane transport of small molecules | |
| Amino acid and oligopeptide SLC transporters |
| No data |
| No data |
| No data |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of SLC15A3 mRNA | affects expression | 17562736 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of SLC15A3 mRNA | affects expression | 16483693 |
| D001104 | Arbutin | Arbutin results in decreased expression of SLC15A3 mRNA | decreases expression | 17103032 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of SLC15A3 mRNA | affects expression | 17484886 |
| D014050 | Toluene | Toluene affects the expression of SLC15A3 mRNA | affects expression | 18653662 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.10 | 18287403 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.45 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.40 | 18445737 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 4.26 | 16124888 16050911 16011737 3786805 16227642 16097048 15673190 18705752 15721981 15700767 10355542 16192424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 2.97 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 2.97 | 18788625 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.77 | 10977129 | |
| MESH:D002547 | Cerebral Palsy | Toluene | 6.39 | 9294310 | |
| MESH:D019465 | Craniofacial Abnormalities | Toluene | 2.89 | 9294310 | |
| MESH:D003643 | Death | Toluene | 6.28 | 6431079 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 4.02 | 16393943 17522070 11529661 12705907 19739265 18071297 19370779 12958197 18713872 14725611 10915739 16109766 11743745 15619225 17562736 10774834 11739529 14986274 12153990 16177239 12540782 12392966 10663392 19085960 14550746 16081117 19164858 11834606 11287661 16227642 12594235 19416960 19923254 11461765 2444490 16781746 17906064 15968718 19420014 11421492 16485898 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 4.02 | 19085960 7179309 15968718 7120509 2869522 6623471 7440962 4309450 10092053 16227642 10915739 11566570 16177239 3786805 21278145 3732212 15998439 9327722 6884620 17522070 19336974 15027814 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.71 | 19426721 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 3.54 | 17595544 15959796 16045604 12795759 16239168 19224547 61145 12631006 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 3.94 | 18705752 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.29 | 16983495 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 4.03 | 19900420 19110552 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.99 | 16870215 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 5.07 | 16899240 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 4.57 | 15338365 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.38 | 12587719 15629191 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 2.98 | 17157831 11408273 16943688 16239168 11903743 16221502 21278145 17334410 17174718 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 1.75 | 16097048 18187930 14716833 12632512 17721639 12667390 16011737 16192424 14512876 12586293 17565644 12958196 18263696 12546737 18166357 18472332 14724832 15730626 17944888 18339082 12445421 12632514 18472094 12649538 14620537 15673190 10355542 17481882 17640975 12666154 12389079 17766677 16638106 17708605 11481614 17525996 15925388 15876570 18420326 18429990 18481824 17823541 18705752 18418968 15931870 12898905 17922224 17557913 15052691 12741479 18279442 15818738 18205269 16027843 15650968 17761835 18395095 16136751 16116963 15996030 15893842 14748882 20821823 15123356 15057751 18251166 18054572 15338365 13678700 18412020 16033810 17631135 12609069 18376398 18317297 17869086 15959796 17805973 17900296 17714472 18006644 15362042 17976157 14716496 17698563 18210741 12445418 16248980 15370692 18156304 16015684 18277467 18395914 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 4.14 | 19460945 12587719 12969438 16610002 19784758 11587558 19014921 16611625 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 4.14 | 16964402 15830285 15720792 16246199 17285989 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 4.65 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 10.59 | 16871587 17185352 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 10.59 | 14706259 16899240 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 2.32 | 19294768 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 2.81 | 12014681 15583823 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.05 | 19513568 | |
| MESH:D008607 | Mental Retardation | Toluene | 3.74 | 9294310 | |
| MESH:D019957 | Motor Skills Disorders | Toluene | 5.64 | 9294310 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.18 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.69 | 16870215 | |
| MESH:D012640 | Seizures | Toluene | 3.95 | 6431079 9294310 | |
| MESH:D013733 | Testicular Diseases | Toluene | 5.49 | 10514026 10048760 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.38 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:19419 | Amino acid and oligopeptide SLC transporters |
| REACT:15518 | Transmembrane transport of small molecules |