AutismKB 2.0

Annotation Detail for NRN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NRN1 ( MGC44811,NRN,dJ380B8.2 )
Gene Full Name: neuritin 1
Band: 6p25.1
Quick LinksEntrez ID:51299; OMIM: 607409; Uniprot ID:NRN1_HUMAN; ENSEMBL ID: ENSG00000124785; HGNC ID: 17972
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic NRN1 mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
D001374 Azacitidine Azacitidine results in decreased expression of NRN1 mRNAdecreases expression 19194470
D004041 Dietary Fats Dietary Fats results in increased expression of NRN1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NRN1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NRN1 mRNA]decreases reaction|increases expression 17942915
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of NRN1 mRNAincreases expression 20713471
D010126 Ozone Ozone results in decreased expression of NRN1 mRNAdecreases expression 17095637
C041786 palm oil palm oil results in increased expression of NRN1 mRNAincreases expression 18042831
D018038 Sodium Selenite Sodium Selenite results in increased expression of NRN1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 7.3710737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 7.376695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2419061943 19052882 16434500 17620307 17162532 18056438
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D020261 Arsenic Poisoning Arsenic 2.9218414634 16251483 12569548 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7016373670 17854713
MESH:D050197 Atherosclerosis Arsenic 7.4012928151 19371607
MESH:D050197 Atherosclerosis Methylcholanthrene 7.4011922910
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9917474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9917474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8716777450 15516495 14754758 18315731 19059883 17626835 18417511
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D002277 Carcinoma Methylcholanthrene 4.1610545420
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7115504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2816507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.2817138121 17162532 19052882 18691550 18393292 20935162 16328049 18785209 16502159 16935385 17978847 21159647 20514400 19107877 18506893 19919837 16288022 20084675 19701751 16698587 18788625 18494052 19208518 11831363 19822196 19394651 3084413 16779866 16878318 16569478 20524982 16681979 17173139 16807293 20727157 20214788 18210153 18056438 17761372 19383236 19539802 17055752 19171122 19519916 20007298 3581430 18978308 20432363 16540662 18665156 20512989 10737359 19418558 20101231 18971187 10672840 16830150 17428255 19335982
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7418922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6115738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5218022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.507505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.5016192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2019107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.2015131321
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Dietary Fats 8.6719551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6721071580 20387270
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.2814633661 10962813
MESH:D005355 Fibrosis Dietary Fats 3.8318296743
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Arsenic 2.9416076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Dietary Fats 5.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.4818785209
MESH:D007333 Insulin Resistance Dietary Fats 7.9818457598 11836018
MESH:D007333 Insulin Resistance Sodium Selenite 7.9814714311
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007938 Leukemia Azacitidine 3.8019148494
MESH:D007951 Leukemia, Myeloid Azacitidine 4.8619077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.0318720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.4519299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0419638242 20032147 18665156 18522880 18407596
MESH:D008107 Liver Diseases Arsenic 4.4111134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4117034775
MESH:D008113 Liver Neoplasms Arsenic 5.0116368122
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0118648771 20501860 18754104 19996281 21278145 19833225 20101389 19642983 20452335 21047994 16942905 21071580 19426721 20492335 19254457 15885732 19690152 10737359 19294768 18978307 19812893 19073162 15175105 19255062 19427195 19551842 19499222 19256749 19638242 20405173 18644402 2422723 12771043 9163691 20137499 2862719 12112319 21167192 19090486 18977376 19850985 20583210 20118626 20434301
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6616267830 3124819 18079962 18282651 19126423 19519916 19009564 18308698 18253720 19004024 18544905 18093689 18164116 17854601 18775883 2563599 19539802 21159647 17942915 16842330 17174075 9362446
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.661399818 598648
MESH:D008171 Lung Diseases Ozone 3.538266340 19066396
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Arsenic 6.8917976673 19168569 17306315
MESH:D008175 Lung Neoplasms Azacitidine 6.8921224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.8920970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.8910545420 20970405 11893704 1399818 16271038 21163286 9230183 16337739 6695378 7750092 15390079 17909032 20512841
MESH:D008175 Lung Neoplasms Ozone 6.897614698 8597069
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D009006 Monosomy Azacitidine 6.4619299654
MESH:D009101 Multiple Myeloma Azacitidine 4.1318443271 19549372
MESH:D009190 Myelodysplastic Syndromes Azacitidine 4.1317611569 18720364 17596541 19805378
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009436 Neural Tube Defects Arsenic 3.6016620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity Dietary Fats 2.3316723640 21332399 11836018 20132043 17217161 18457598 18674790 20518802 19632207
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3316905509 15371236 6392382
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D011014 Pneumonia Ozone 4.7318929643 18007984 18381685
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms Arsenic 2.7216140617
MESH:D011471 Prostatic Neoplasms Azacitidine 2.7218324645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7218760546
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D012871 Skin Diseases Arsenic 2.8019834688 17453740 17548696 18709164 16759981 15952646 6392382 17050553 16702368 16353154 17938729
MESH:D012878 Skin Neoplasms Arsenic 3.1017976673 15504454 17029826 16251483 17050553 19538983
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8919429237 11144890 18640142 19322015 17306315 15987713 17976673
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38477
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved