AutismKB 2.0

Annotation Detail for REEP2


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Basic Information Top
Gene Symbol:REEP2 ( C5orf19,SGC32445 )
Gene Full Name: receptor accessory protein 2
Band: 5q31.2
Quick LinksEntrez ID:51308; OMIM: 609347; Uniprot ID:REEP2_HUMAN; ENSEMBL ID: ENSG00000132563; HGNC ID: 17975
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of REEP2 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of REEP2 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of REEP2 mRNAincreases expression 20106945
D015735 Mifepristone Mifepristone results in decreased expression of REEP2 mRNAdecreases expression 17584828
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of REEP2 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9416835338 16251483 12569548 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.143084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.1416507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9917687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9920419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6416973168 18022660
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6614725611 11421492 19420014 10915739 11743745 16485898 19164858 18071297 14550746 11461765 2444490 10774834 19739265 17906064 15619225 19416960 10663392 11834606 11739529 19085960 16781746 16393943 12153990 16227642 18713872 16177239 19923254 15968718 12540782 14986274 11529661 19370779 11287661 16081117 12594235 17562736 12958197 12705907 16109766 17522070 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004715 Endometriosis Mifepristone 4.7116134523
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4819176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 2.9816076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007642 Keratosis Arsenic 5.5316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.3111587558 19784758 16610002 12969438 12587719 19014921 19460945 16611625
MESH:D008107 Liver Diseases Arsenic 4.3111134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 8.0916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0920195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 8.0915890375 16377806 20007298
MESH:D008175 Lung Neoplasms Arsenic 2.6217976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6218520028 20064080 20464547 6695378 18569708 20869020 18816296 20135361 17053015
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2715371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3311141357
MESH:D009369 Neoplasms pirinixic acid 5.3317405874
MESH:D009436 Neural Tube Defects Arsenic 3.6716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Arsenic 5.5817306315
MESH:D010051 Ovarian Neoplasms Mifepristone 5.5816525653
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5315371236 6392382 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 3.2316140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2317292933
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012871 Skin Diseases Arsenic 2.8217050553 16759981 15952646 19834688 16353154 16702368 18709164 6392382 17938729 17453740 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.3017029826 16251483 15504454 17976673 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.3019755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5517976673 19429237 17306315 18640142 11144890 15987713 19322015
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5517053015
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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