AutismKB 2.0

Annotation Detail for SLC25A37


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Basic Information Top
Gene Symbol:SLC25A37 ( MFRN,MSC,MSCP,PRO1278,PRO1584,PRO2217 )
Gene Full Name: solute carrier family 25, member 37
Band: 8p21.2
Quick LinksEntrez ID:51312; OMIM: 610387; Uniprot ID:MFRN1_HUMAN; ENSEMBL ID: ENSG00000147454; HGNC ID: 29786
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SLC25A37 mRNAdecreases expression 12958071
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC25A37 mRNAdecreases expression 20018196
19150397
C099555 CD 437 CD 437 results in decreased expression of SLC25A37 mRNAdecreases expression 12958071
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC25A37 mRNAaffects expression 17555576
D010634 Phenobarbital Phenobarbital results in increased expression of SLC25A37 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC25A37 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC25A37 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of SLC25A37 mRNAincreases expression 18301758
D012643 Selenium Selenium results in increased expression of SLC25A37 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of SLC25A37 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen results in increased expression of SLC25A37 mRNAincreases expression 17555576
D014212 Tretinoin Tretinoin results in increased expression of SLC25A37 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6716206674 16197459
MESH:D001943 Breast Neoplasms Tamoxifen 2.1519103187 20544844 16873071 18984771 19189212 19155303 16273361 18351453 17242785 15668708 19200415 20005174 19410462 16818667 21138602 18855134 20859285 20135344 17893378 11161223 18815881 18821012 19244106 18425577 20390343 18997820 19288272 18629630 17049068 19066611 21152245 16202921 19059307 20065188 19487384 19289846 17261762 15565566 17440819 19142967 19115204 19221464 19084267 19011961 19189210
MESH:D001943 Breast Neoplasms Tretinoin 2.1516166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7620935162 6705139 20007298 1701930 17173139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.761917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2516105132 17681005 16919318 17110522 15861022 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Selenium 10.3717936198
MESH:D003092 Colitis Tretinoin 10.3717035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9142499 8800419 9224671 17551590 16925845 9125849 9664655 9211117 14991402
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2215131321
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.8620544844 19155303 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8616569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tretinoin 3.7316938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2715345470
MESH:D005234 Fatty Liver pirinixic acid 14.2720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 14.2714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9914991402 9664655
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3619176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 2.4519457130
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2118625569
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2819642359 16788101 9834237 17368321 16823087 17649720 17339181 17217047 17107899 15748426 17294898 16766008 17712046 16935935 19035177 16891316 17361223 12679006 16140955 17301526 19029980 19075265 17506722 19225113 16331271
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0021047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5718564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5716248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 2.2119363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.8119812893 19073162 8742319 21047994 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 7.8116377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 7.8116684651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.8218308698 6150874 2563599 1399818 17172636
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4616827153 11731420 19196723 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tamoxifen 3.3819393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 5.2117405874
MESH:D009369 Neoplasms Tretinoin 5.2116594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms CD 437 5.3917474084
MESH:D010051 Ovarian Neoplasms Tretinoin 5.3916936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4916965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012640 Seizures Phenobarbital 2.823137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.721399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.6716720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6716712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142670909
    • No data
    No data
    Releated drug ID Related drug Name
    PA449177cytarabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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