AutismKB 2.0

Annotation Detail for TXNDC3


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Basic Information Top
Gene Symbol:TXNDC3 ( CILD6,NME8,SPTRX2 )
Gene Full Name: thioredoxin domain containing 3 (spermatozoa)
Band: 7p14.1
Quick LinksEntrez ID:51314; OMIM: 607421; Uniprot ID:TXND3_HUMAN; ENSEMBL ID: ENSG00000086288; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Ciliary dyskinesia, primary, 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of TXNDC3 mRNAincreases expression 19774075
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TXNDC3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TXNDC3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TXNDC3 mRNAaffects cotreatment|increases expression 17942748
D013629 Tamoxifen Tamoxifen affects the expression of TXNDC3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TXNDC3 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2018218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.2018651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.5019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.5012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9221138602 20544844 17261762 11161223 17440819 18984771 17049068 19011961 21152245 16202921 19487384 19059307 16873071 19103187 18815881 18351453 20859285 18425577 20390343 15565566 19200415 19142967 19189210 19244106 19115204 16273361 19221464 20005174 19189212 19289846 19410462 17242785 17893378 18629630 19288272 16818667 19155303 18997820 18855134 18821012 20135344 19066611 20065188 19084267 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.7218974383
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1711677210 15861022 16919318 17110522 16105132 17681005 17333356
OMIM:610852 CILIARY DYSKINESIA, PRIMARY, 6 marker/mechanism
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2416354765 15340226 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1615265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.6819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2919155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Amiodarone 15.7414986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.7415345470
MESH:D005234 Fatty Liver Tamoxifen 15.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Amiodarone 10.4715265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.4715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 18606429 16354765 15340226 8697196
MESH:D006937 Hypercholesterolemia Amiodarone 4.308137927 9751232
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 5.0818020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tamoxifen 5.4919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D008064 Lipidoses Amiodarone 8.8515342952 17567588
MESH:D008064 Lipidoses Tamoxifen 8.8515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.8016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.8911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.2018516814
MESH:D008175 Lung Neoplasms Tamoxifen 2.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3419555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8611731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D009181 Mycoses Amiodarone 5.6212754197 17974566
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.9415861022 16919318
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9711597910 12490602 12832656
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.7218724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 14.1116709447
MESH:D013088 Spermatocele Tamoxifen 14.1116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D013276 Stomach Ulcer Amiodarone 3.7418087811
MESH:D013610 Tachycardia Amiodarone 4.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7019225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013959 Thyroid Diseases Amiodarone 14.6019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 14.6012697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.4218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.8211989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4817572228 8653321 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134925065
    • No data
    Releated disease ID Related disease Name
    PA445174Osteoarthritis
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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