AutismKB 2.0

Annotation Detail for PHF21A


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Basic Information Top
Gene Symbol:PHF21A ( BHC80,KIAA1696 )
Gene Full Name: PHD finger protein 21A
Band: 11p11.2
Quick LinksEntrez ID:51317; OMIM: 608325; Uniprot ID:PF21A_HUMAN; ENSEMBL ID: ENSG00000135365; HGNC ID: 24156
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PHF21A mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of PHF21A mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PHF21A mRNAincreases expression 20504355
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1516206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.8611589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.043084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0415553829 14691202 15073043 16217749 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.7419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.7712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.6315213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6819416960 16393943 11421492 11739529 16177239 12540782 14725611 12153990 16781746 2444490 12594235 12392966 11834606 19370779 15968718 14550746 16227642 16485898 19420014 11529661 19164858 17562736 19739265 10663392 15619225 10915739 19085960 12705907 14986274 19923254 16081117 11287661 12958197 18071297 17906064 11743745 11461765 10774834 17522070 18713872 16109766
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7316530937
MESH:D005234 Fatty Liver arsenic trioxide 3.7715073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.8516904648
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D007938 Leukemia arsenic trioxide 3.0115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.0516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.2419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916968895 17050201 19850784 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4815748426 19075265 15336539 15213294 11161223 16823087 17869043 11468182 16966277 16112521 12018890 19642359 15622746 17107899 16330433 17217047 16331271 19035177 17649720 16891316 19225113 9834237 12679006 17712046 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.9416882451
MESH:D008107 Liver Diseases Acetaminophen 1.7111587558 19460945 16610002 12969438 12587719 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 5.0014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.0020195826 21137059
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5119825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.516695378 20464547 20064080 18816296 20869020 18520028 20135361 17053015 18569708
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4115949261 19549372 14977855 11468182 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3616882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.5416624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5112452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6415580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6919927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.0919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0917292933
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.5416646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5410029692 19755658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.452093021 20155912
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.4319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.7015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5111780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5117053015
MESH:D014581 Urticaria Acetaminophen 3.5010982225
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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