AutismKB 2.0

Annotation Detail for AMZ2


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Basic Information Top
Gene Symbol:AMZ2 ( - )
Gene Full Name: archaelysin family metallopeptidase 2
Band: 17q24.2
Quick LinksEntrez ID:51321; OMIM: NA; Uniprot ID:AMZ2_HUMAN; ENSEMBL ID: ENSG00000196704; HGNC ID: 28041
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of AMZ2 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of AMZ2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of AMZ2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AMZ2 mRNAincreases expression 17942748
D007657 Ketone Bodies Ketone Bodies results in decreased expression of AMZ2 mRNAdecreases expression 16807920
D013629 Tamoxifen Tamoxifen affects the expression of AMZ2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Tamoxifen 2.1719221464 17440819 19155303 16818667 18629630 18855134 15668708 16202921 18815881 19103187 15565566 19289846 17893378 18984771 19189212 19142967 19189210 19244106 20544844 17049068 11161223 18997820 20135344 16273361 19115204 20005174 21152245 18425577 16873071 19066611 21138602 19059307 19410462 18351453 19084267 17242785 20859285 19487384 20390343 20065188 19200415 18821012 19288272 17261762 19011961
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9716924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6515861022 16105132 17333356 11677210 17110522 16919318 17681005
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.662444490 17522070 16485898 11461765 12594235 18071297 11743745 17906064 18713872 10915739 17562736 16227642 11739529 19416960 16109766 11834606 10774834 14986274 16393943 12705907 19923254 11287661 16177239 12958197 19370779 11421492 15619225 14725611 19420014 19739265 19164858 11529661 16081117 14550746 19085960 12153990 15968718 10663392 12392966 12540782 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2616202921 17893378 19155303 20544844
MESH:D005234 Fatty Liver Cyclosporine 15.3219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3215345470
MESH:D005234 Fatty Liver Tamoxifen 15.3214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3318625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 19784758 16611625 12969438 19460945 19014921 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8311731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4617572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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