Annotation Detail for SPG21
Basic Information Top
| Gene Symbol: | SPG21 ( ACP33,GL010,MASPARDIN,MAST ) |
|---|---|
| Gene Full Name: | spastic paraplegia 21 (autosomal recessive, Mast syndrome) |
| Band: | 15q22.31 |
| Quick Links | Entrez ID:51324; OMIM: 608181; Uniprot ID:SPG21_HUMAN; ENSEMBL ID: ENSG00000090487; HGNC ID: 20373 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| No data |
| No data |
| No data |
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| Desease Name |
|---|
| Mast syndrome |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of SPG21 mRNA | affects expression | 17562736 |
| D002995 | Clofibric Acid | Clofibric Acid affects the expression of SPG21 mRNA | affects expression | 17602206 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SPG21 mRNA | decreases expression | 18042831 |
| C041786 | palm oil | palm oil results in decreased expression of SPG21 mRNA | decreases expression | 18042831 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000799 | Angioedema | Acetaminophen | 4.57 | 10982225 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 4.45 | 15238619 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.40 | 18445737 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.24 | 20435547 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.79 | 10977129 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.67 | 19420014 12540782 17562736 11739529 16177239 11743745 11287661 18713872 12392966 10663392 19370779 17906064 19739265 12153990 17522070 18071297 19164858 10774834 16081117 11529661 15619225 14550746 12594235 12705907 11461765 16485898 12958197 2444490 14986274 19923254 16393943 11421492 11834606 16781746 14725611 10915739 15968718 19085960 16109766 16227642 19416960 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.82 | 19426721 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.73 | 18367378 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 3.66 | 18296743 17967931 19551842 19004024 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 4.08 | 18296743 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.40 | 16983495 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.02 | 16870215 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 4.02 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 4.08 | 21332399 | |
| MESH:D007249 | Inflammation | Dietary Fats | 2.60 | 20412841 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 3.34 | 18457598 11836018 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.40 | 15629191 12587719 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 3.07 | 18296743 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.70 | 19014921 11587558 19460945 19784758 16611625 16610002 12969438 12587719 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.63 | 16871587 17185352 | |
| MESH:D008113 | Liver Neoplasms | Clofibric Acid | 2.81 | 17602206 | |
| OMIM:248900 | MAST SYNDROME | marker/mechanism | |||
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.13 | 19513568 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.21 | 18514411 | |
| MESH:D009765 | Obesity | Dietary Fats | 2.36 | 11836018 19632207 20132043 18457598 17217161 16723640 21332399 18674790 20518802 | |
| MESH:D010146 | Pain | Acetaminophen | 2.73 | 16870215 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.44 | 10982225 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 4.11 | 16723640 |
| No data |