AutismKB 2.0

Annotation Detail for PRR16


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Basic Information Top
Gene Symbol:PRR16 ( DSC54,MGC104614 )
Gene Full Name: proline rich 16
Band: 5q23.1
Quick LinksEntrez ID:51334; OMIM: NA; Uniprot ID:PRR16_HUMAN; ENSEMBL ID: ENSG00000184838; HGNC ID: 29654
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PRR16 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of PRR16 mRNAincreases expression 15761015
D016572 Cyclosporine Cyclosporine results in increased expression of PRR16 mRNAincreases expression 20106945
D005492 Folic Acid Folic Acid affects the expression of PRR16 mRNAaffects expression 17320366
D010634 Phenobarbital Phenobarbital results in increased expression of PRR16 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRR16 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of PRR16 mRNAaffects binding|decreases expression 16214954
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6511752688 15322242 14514962
MESH:D058186 Acute Kidney Injury Folic Acid 4.6116316344 17003819 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D000236 Adenoma Folic Acid 3.9416963246
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.7517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.7516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.7516835633
MESH:D000544 Alzheimer Disease Folic Acid 3.0917116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.9916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Folic Acid 2.2916777985
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7615553829 14691202 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.761701930 6705139 20007298 17173139 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Folic Acid 4.1316755160
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D002971 Cleft Lip Folic Acid 4.1021254359
MESH:D002972 Cleft Palate Folic Acid 6.438946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.4312621046 8697196 16354765 15668235 15340226
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8520501625
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8516963246 17087956 17245555 16985020 17116713
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5320055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.7516886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7517107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7819164858 14550746 16393943 14725611 19085960 19739265 12153990 11287661 19370779 10915739 10663392 16227642 2444490 17906064 15619225 12958197 12392966 11739529 10774834 11529661 15968718 19416960 16177239 17522070 18713872 11461765 17562736 14986274 19420014 18071297 16109766 11834606 12594235 12705907 16081117 11743745 19923254 11421492 16485898 12540782 16781746
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Folic Acid 4.1817301261
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D017889 Exfoliation Syndrome Folic Acid 5.8916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver arsenic trioxide 14.7615073043
MESH:D005234 Fatty Liver Cyclosporine 14.7619224547
MESH:D005234 Fatty Liver pirinixic acid 14.7620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Cyclosporine 9.7012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.7020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 12.8016983495
MESH:D005756 Gastritis Folic Acid 12.8017171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005901 Glaucoma Folic Acid 5.3816504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Folic Acid 7.3017286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.3010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 16.5816109766
MESH:D006529 Hepatomegaly pirinixic acid 16.5819176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.5812621046 16120746 15340226
MESH:D006679 HIV Seropositivity Folic Acid 5.8917209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.7416865747 16755160 16433478 16395265 16397167
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.288314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 19850784 20471514 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3816891316 17712046 19225113 12712474 17649720 15748426 11161223 15336539 19075265 9834237 17107899 16330433 19642359 15622746 11468182 17869043 16823087 12018890 15213294 17217047 16966277 16331271 16112521 12679006 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008107 Liver Diseases Acetaminophen 6.9619784758 11587558 19460945 16611625 19014921 16610002 12969438 12587719
MESH:D008107 Liver Diseases Folic Acid 6.9616877991
MESH:D008107 Liver Diseases Phenobarbital 6.9619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 11.4314682389
MESH:D008113 Liver Neoplasms Phenobarbital 11.4319812893 19482888 19073162 8742319 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 11.4320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.7720377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.7718308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3619825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3619555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.4017718048
MESH:D019767 Maxillofacial Abnormalities Folic Acid 6.0916832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919549372 19417148 15949261 14977855 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 8.2010525206
MESH:D009436 Neural Tube Defects Folic Acid 8.2017438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009503 Neutropenia Folic Acid 4.8116322990
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5816965848
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.8112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.812563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D051437 Renal Insufficiency Folic Acid 5.1415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012559 Schizophrenia Folic Acid 2.9216641680
MESH:D012640 Seizures Phenobarbital 2.874039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012871 Skin Diseases Folic Acid 3.3018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013118 Spinal Cord Diseases Folic Acid 5.8916361298
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.8417007042
MESH:D013274 Stomach Neoplasms Folic Acid 2.8417171786
MESH:D020521 Stroke Folic Acid 4.5516517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.931399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5711780464 12845720 20435036 12973940
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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