AutismKB 2.0

Annotation Detail for DACT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DACT1 ( DAPPER,DAPPER1,DPR1,FRODO,HDPR1,THYEX3 )
Gene Full Name: dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
Band: 14q23.1
Quick LinksEntrez ID:51339; OMIM: 607861; Uniprot ID:DACT1_HUMAN; ENSEMBL ID: ENSG00000165617; HGNC ID: 17748
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of DACT1 mRNAaffects expression 19414516
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DACT1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DACT1 mRNAdecreases expression 20713471
C006780 bisphenol A bisphenol A affects the expression of DACT1 mRNAaffects expression 20170705
C014347 decitabine [decitabine affects the methylation of DACT1 promoter] which affects the expression of DACT1 mRNAaffects expression|affects methylation 18538736
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in decreased expression of DACT1 mRNAdecreases expression 18242016
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of DACT1 mRNAaffects cotreatment|decreases expression 17404688
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of DACT1 mRNAdecreases expression 20713471
D010081 Oxazolone Oxazolone results in decreased expression of DACT1 mRNAdecreases expression 18242016
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of DACT1 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of DACT1 mRNAdecreases expression 17404688
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of DACT1 mRNAaffects cotreatment|increases expression 19059307
D012643 Selenium Selenium results in decreased expression of DACT1 mRNAdecreases expression 19244175
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of DACT1 mRNAaffects cotreatment|increases expression 19059307
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of DACT1 mRNAdecreases expression 18242016
D002762 Cholecalciferol Cholecalciferol results in increased expression of DACT1 mRNAincreases expression 17170073
D014810 Vitamin E Vitamin E results in decreased expression of DACT1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2811473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.876695378
MESH:D000236 Adenoma Methylcholanthrene 6.876695378 10545420
MESH:D000419 Albuminuria Raloxifene 4.6017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.506091945 20032816 15590891 12684321 18394133 16792590 15590890 6091946 17015710 11742282 10934080 12585506 8156442 12762349 3040596 11467998 16210060 15855793 19187332 10797510 7684630 11077013 170078
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4511922910
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.0416142846
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 11.0115845082 15665606 15380490
MESH:D001930 Brain Injuries Raloxifene 11.0116580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.8420146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 5.8417123778
MESH:D001943 Breast Neoplasms decitabine 5.8418320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 5.8416675129 12948864 17261762 17018787 19861407 17289903 14630087 18497071
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.8417474063
MESH:D001943 Breast Neoplasms Progesterone 5.8417614352 16175315 15562024
MESH:D001943 Breast Neoplasms Raloxifene 5.8417440819 15775269 17261762 17893378 17049068 15572757 16837676 16912660 17242785 15758505 17595753 17952589
MESH:D001943 Breast Neoplasms Tamoxifen 5.8417049068 15668708 19066611 19189212 16873071 18629630 19011961 18855134 17440819 19155303 21152245 15565566 18815881 20544844 18821012 19189210 19084267 19142967 21138602 16202921 19288272 19115204 20065188 19289846 19200415 18351453 17893378 19103187 20859285 20135344 19221464 11161223 19410462 20005174 17261762 18984771 18425577 18997820 19487384 17242785 19244106 19059307 16818667 20390343 16273361
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 5.8411921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.548156442 15590891 12507178
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9416050911
MESH:D002277 Carcinoma Methylcholanthrene 3.9710545420
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6021507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6016924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6820419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6819215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5117572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.9416192471
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8517373747 19159591
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 7.8515491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 7.8512956900 15491423 18759878
MESH:D003877 Dermatitis, Contact Oxazolone 10.2112811023 15944321
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 10.2117010967
MESH:D003928 Diabetic Nephropathies Estradiol 15.0419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.0417308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.0419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury Selenium 2.1815131321
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004487 Edema Raloxifene 3.3415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.5017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.5015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.5019031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D016889 Endometrial Neoplasms Estradiol 7.4011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.4017893378 20544844 19155303 16202921
MESH:D004715 Endometriosis Progesterone 3.7716134523
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.668156442
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.7718447907
MESH:D005234 Fatty Liver Raloxifene 8.0017473493
MESH:D005234 Fatty Liver Tamoxifen 8.0019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9614633661 10962813
MESH:D006258 Head and Neck Neoplasms decitabine 3.4919215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6920471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6916080930
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 10.1517088409
MESH:D019584 Hot Flashes Vitamin E 10.1514716179
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.6010880147 11019492
MESH:D006973 Hypertension Raloxifene 2.8717577099 15787275
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007248 Infertility, Male decitabine 3.2017581917
MESH:D007249 Inflammation Progesterone 5.1715869954
MESH:D007249 Inflammation Tamoxifen 5.1719457130
MESH:D007251 Influenza, Human Selenium 11.0616624496
MESH:D007251 Influenza, Human Vitamin E 11.0616624496
MESH:D007333 Insulin Resistance bisphenol A 7.4416393666
MESH:D007333 Insulin Resistance Estradiol 7.4416393666 16627594
MESH:D007674 Kidney Diseases Estradiol 6.1115618244
MESH:D007674 Kidney Diseases Vitamin E 6.1112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms Estradiol 7.3915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3918625569
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D007938 Leukemia decitabine 3.0719235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3819010910 18704418 17679729 18206229 18460780 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D008064 Lipidoses Tamoxifen 3.1617567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5218564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5216169303
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.469163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4621137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 7.4616684651
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.248603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.24598648 1399818
MESH:D008171 Lung Diseases Vitamin E 3.1816863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.6114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6118569708 18520028 18816296 17053015 20464547 6695378 20064080 20869020 20135361
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.6116271038 21163286 20970405 16337739 7750092 20512841 15390079 11893704 1399818 17909032 9230183 10545420 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.6118625569
MESH:D008175 Lung Neoplasms Vitamin E 6.6111062179
MESH:D008223 Lymphoma decitabine 3.4219470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.2911408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.2917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 14.2915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.2916827153 19196723 14580682 19196722 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.7519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.7519453300
MESH:D008545 Melanoma decitabine 5.3016505122 17785578
MESH:D008545 Melanoma Dinitrochlorobenzene 5.3017334785 12202904
MESH:D008545 Melanoma Tamoxifen 5.3012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009101 Multiple Myeloma decitabine 7.5118172295
MESH:D009101 Multiple Myeloma Raloxifene 7.5116497877
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3819157545 16882708 19010910 18608210
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1111141357
MESH:D009369 Neoplasms decitabine 5.1119470736 19116145 17925555
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.751670384
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009421 Nervous System Malformations bisphenol A 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.7211077013 8156442 12585506 3040596 6091946 18394133 6091945
MESH:D010024 Osteoporosis Raloxifene 3.3919059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2315758505 17823083 17893378 15579764
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms decitabine 7.9319331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 7.9319401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.9317393432 16525653
MESH:D010190 Pancreatic Neoplasms decitabine 2.7719294695
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma marker/mechanism 17148581
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.9710548101
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.5720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.5720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1016740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.1017024972
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1016220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1015084515
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.6514606601
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.4316940033 20219652 7692837
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.1518447907
MESH:D012208 Rhabdomyosarcoma decitabine 4.4119155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.5819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.3112617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.5419075512
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3719755658 10029692
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.5419050374 19075512
MESH:D013088 Spermatocele Tamoxifen 4.3216709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.9415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.9419457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4619037991
MESH:D020521 Stroke Raloxifene 8.7216837676
MESH:D020521 Stroke Vitamin E 8.7216517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016684133 16045194
MESH:D013964 Thyroid Neoplasms decitabine 3.3317967635
MESH:D013978 Tibial Fractures Estradiol 13.8219048282
MESH:D013978 Tibial Fractures Raloxifene 13.8219048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.9717053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.9719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.9717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.9717572228 8653321 16712894
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014604 Uveal Neoplasms decitabine 4.9417785578
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved