AutismKB 2.0

Annotation Detail for FZR1


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Basic Information Top
Gene Symbol:FZR1 ( CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1,KIAA1242 )
Gene Full Name: fizzy/cell division cycle 20 related 1 (Drosophila)
Band: 19p13.3
Quick LinksEntrez ID:51343; OMIM: 603619; Uniprot ID:FZR_HUMAN; ENSEMBL ID: ENSG00000105325; HGNC ID: 24824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200087PLK1 signaling events
200166Aurora A signaling
No data
Pathway IDPathway Name
500399Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
500391Regulation of APC/C activators between G1/S and early anaphase
500390APC/C-mediated degradation of cell cycle proteins
500401Autodegradation of Cdh1 by Cdh1:APC/C
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FZR1 mRNAaffects expression 21346803
C014464 3,4-dichloroaniline 3,4-dichloroaniline results in decreased expression of FZR1 mRNAdecreases expression 17292976
D000082 Acetaminophen Acetaminophen affects the expression of FZR1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FZR1 mRNAincreases expression 20504355
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of FZR1 mRNAdecreases expression 15336504
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FZR1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FZR1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FZR1 mRNAaffects cotreatment|increases expression 17942748
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of FZR1 mRNAincreases expression 17560707
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of FZR1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of FZR1 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of FZR1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FZR1 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin results in decreased expression of FZR1 mRNAdecreases expression 18042343
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of FZR1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of FZR1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.7919115204 18984771 17440819 20065188 20544844 17242785 18629630 18821012 19221464 19066611 17049068 16818667 19155303 20135344 18351453 18997820 15565566 20005174 19011961 16873071 15668708 20390343 19142967 19410462 17893378 19244106 19084267 18425577 19487384 20859285 18815881 19288272 19189210 19103187 11161223 19289846 18855134 17261762 16202921 21152245 19189212 19059307 19200415 21138602 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6016924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9517110522 16105132 17333356 17681005 11677210 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 15668235 8697196 16354765 12621046
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5119769572
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2011529661 11287661 12540782 18071297 12153990 16177239 14550746 19416960 12594235 16109766 16485898 19739265 19370779 19085960 17562736 18713872 16393943 11461765 19164858 17906064 10774834 11743745 10663392 12705907 2444490 16781746 19923254 11834606 19420014 15968718 12392966 14725611 15619225 10915739 17522070 16081117 12958197 14986274 11421492 16227642 11739529
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema perfluorooctanoic acid 7.3117259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1116202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0615345470
MESH:D005234 Fatty Liver Tamoxifen 8.0619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.4211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.4216080930
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.133609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1312621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.1516870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.1512083418
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9017937319
MESH:D007248 Infertility, Male vinclozolin 6.9016467254
MESH:D007249 Inflammation perfluorooctanoic acid 8.6812083418
MESH:D007249 Inflammation Tamoxifen 8.6819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6812200463 12878042
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6918625569
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 13.468812269
MESH:D007984 Leydig Cell Tumor vinclozolin 13.4616417039
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5216169303
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 11587558 19784758 16611625 19460945 12587719 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0421137059 20195826
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 11.0414757943 18709148
MESH:D008113 Liver Neoplasms Tamoxifen 11.0416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9220869020 20135361 6695378 18569708 20064080 20464547 17053015 18816296 18520028
MESH:D008175 Lung Neoplasms Tamoxifen 4.9218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9211062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2719196722 19196723 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008708 Methemoglobinemia 3,4-dichloroaniline 5.874714336
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.099802331
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5312819281 16049721
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 17.2517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.2511399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.2518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5117292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5115067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5115084515
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6819755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.688532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.5116712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04120 Ubiquitin mediated proteolysis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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