AutismKB 2.0

Annotation Detail for TAOK3


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Basic Information Top
Gene Symbol:TAOK3 ( DKFZp666H245,DPK,FLJ31808,JIK,MAP3K18 )
Gene Full Name: TAO kinase 3
Band: 12q
Quick LinksEntrez ID:51347; OMIM: NA; Uniprot ID:TAOK3_HUMAN; ENSEMBL ID: ENSG00000135090; HGNC ID: 18133
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200014p38 MAPK signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TAOK3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TAOK3 mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TAOK3 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of TAOK3 mRNAincreases expression 16002434
D004642 Emodin Emodin results in decreased expression of TAOK3 mRNAdecreases expression 16045814
D005472 Fluorouracil TAOK3 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C106014 gedunin gedunin results in decreased expression of TAOK3 mRNAdecreases expression 17010675
D010634 Phenobarbital Phenobarbital results in decreased expression of TAOK3 mRNAdecreases expression 19270015
D020849 Raloxifene Raloxifene results in increased expression of TAOK3 mRNAincreases expression 19429434
D012402 Rotenone Rotenone results in decreased expression of TAOK3 mRNAdecreases expression 19013527
D013629 Tamoxifen Tamoxifen results in increased expression of TAOK3 mRNAincreases expression 19429434
C050414 tripterine tripterine results in decreased expression of TAOK3 mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4920127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.4917638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.803712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.806695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.1217620307
MESH:D000419 Albuminuria Raloxifene 4.7217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000740 Anemia Fluorouracil 3.8116511603 17963324 15504547
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.3811237771
MESH:D001943 Breast Neoplasms Fluorouracil 2.3815136595 16595493 18357371 16557594 16110121 19217205 18608205
MESH:D001943 Breast Neoplasms Raloxifene 2.3815758505 16912660 15775269 16837676 17893378 17261762 15572757 17952589 17440819 17595753 17049068 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 2.3818821012 19142967 20065188 18815881 19487384 18855134 17049068 19289846 21138602 19189210 19288272 19103187 17440819 20135344 19084267 18984771 16873071 17893378 19011961 17242785 19410462 19189212 20390343 19115204 21152245 19066611 18997820 16202921 17261762 19059307 19200415 20544844 20859285 20005174 15668708 15565566 18351453 19155303 18629630 11161223 19221464 16273361 19244106 18425577 16818667
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 3.6517121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.057296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0516799960 17088986 16332177 17045692 18930000 17971768
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.051701930 17173139 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.0516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.657296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6518695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.7411237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7418986760 16757204 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.8517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.8517572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.837505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.239022650 19486331
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517287894 17725105 17016597 15001691 17169374 16510598 17018589 18772588 16340194 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 16331619 17401013 20501625 18288408 16391804 17094418 17695437 16303861 16282729 18509181 16524972 15148649 18802399 18383874 15289873 17454858 17016601 18448328 17594712 14970324 18949393
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.948156756 14531868 18759878 8970840 2524372 11298694 12868966 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3617308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.3619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.957440962 9022650 6679447 18648102 11289319 16192314 18692083 9328219 18289764 1440618 6482804 8291058 9653073
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema Raloxifene 3.4415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 16.2215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.2215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.2219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1117893378 16202921 20544844 19155303
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.393581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3916337965 16481741 16785472 17638652 15173087
MESH:D005234 Fatty Liver Raloxifene 8.3617473493
MESH:D005234 Fatty Liver Tamoxifen 8.3614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Emodin 4.9419474275
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4615102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly Phenobarbital 3.6216109766
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Raloxifene 2.9015787275 17577099
MESH:D007249 Inflammation Tamoxifen 2.4119457130
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.566582329
MESH:D007680 Kidney Neoplasms Fluorouracil 18.5616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 18.5618625569
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 5.1317077332
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Emodin 2.9915288473
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.9918564211
MESH:D008107 Liver Diseases Phenobarbital 2.1919363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0421137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 11.0417045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 11.048742319 21047994 19812893 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 11.0416684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.171399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.1718308698 17172636 6150874 1399818 2563599
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5120869020 18569708 18520028 17053015 6695378 20464547 20064080 18816296 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 3.5115246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.5118625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6919196723 19196722 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8116757204 18986760
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2311141357
MESH:D009369 Neoplasms Fluorouracil 5.2316928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19196722 19200415
MESH:D009410 Nerve Degeneration Rotenone 3.9617356569 18619942 15790535
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.236482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010024 Osteoporosis Raloxifene 3.4619059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3415579764 17823083 17893378 15758505
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4716500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010300 Parkinson Disease Rotenone 3.0119114014 19232380 18191903 11445065 16140633 18619942 15451049 16412576 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 4.1815927086 15574749 15795934 18197244
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011230 Precancerous Conditions Phenobarbital 3.722563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9315572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8616289102 15754350 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8619082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8615731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8615067354
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1118286688 15538739 16160472 18722050
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1718551238
MESH:D012640 Seizures Phenobarbital 6.173137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013088 Spermatocele Tamoxifen 4.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4420155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4418396642 17498489 19084572 17172411 16951190 19015929 15786421 17522103 16424979 18567086
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.433712494 6582329 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.431399818
MESH:D013978 Tibial Fractures Raloxifene 5.3819048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.2316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.238074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.2317053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.2317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 16.238653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9816803524
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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