AutismKB 2.0

Annotation Detail for KLRF1


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Basic Information Top
Gene Symbol:KLRF1 ( CLEC5C,MGC119907,MGC119908,MGC119909,NKp80 )
Gene Full Name: killer cell lectin-like receptor subfamily F, member 1
Band: 12p13.31
Quick LinksEntrez ID:51348; OMIM: 605029; Uniprot ID:KLRF1_HUMAN; ENSEMBL ID: ENSG00000150045; HGNC ID: 13342
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of KLRF1 mRNAaffects cotreatment|decreases expression 17093179
D001151 Arsenic Arsenic affects the expression of KLRF1 mRNAaffects expression 18414638
D002794 Choline Choline affects the expression of KLRF1 mRNAaffects expression 17616785
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of KLRF1 mRNAaffects cotreatment|decreases expression 17093179
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of KLRF1 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of KLRF1 promoteraffects acetylation|affects methylation 18448484
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KLRF1 mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma Arsenic 15.3217306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 15.3217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9312569548 16251483 18414634 16835338
MESH:D050197 Atherosclerosis Arsenic 3.4019371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Choline 2.3516818868
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.813084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8117306315 16507464
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8117306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.0615504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0618572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.6317938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5618022660 16973168
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 7.7819716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.7819524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15340226 15668235 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D002658 Developmental Disabilities Choline 4.8516818868
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7811287661 12540782 17906064 11529661 12705907 19923254 15968718 12594235 19085960 12153990 10915739 19420014 16081117 10663392 11461765 11743745 12958197 18071297 19416960 15619225 16109766 18713872 17522070 16485898 11421492 19370779 16227642 2444490 14725611 14550746 16781746 16393943 14986274 19164858 11834606 11739529 19739265 10774834 16177239 12392966 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 5.529931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5218850075 18670907
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007248 Infertility, Male sodium arsenite 3.1612646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007642 Keratosis Arsenic 5.3916930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 6.4515629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.4520008137
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.2619014921 12587719 12969438 11587558 16611625 16610002 19460945 19784758
MESH:D008107 Liver Diseases Arsenic 4.2611134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 7.9916368122
MESH:D008113 Liver Neoplasms sodium arsenite 7.9916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms Arsenic 3.5917306315 17976673 19168569
MESH:D008175 Lung Neoplasms sodium arsenite 3.5916712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5911884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D017202 Myocardial Ischemia Arsenic 9.7515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.7512213967
MESH:D009369 Neoplasms sodium arsenite 2.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects Arsenic 8.0316620997
MESH:D009436 Neural Tube Defects sodium arsenite 8.0312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.2717306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2715276417 17306315
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.396392382 16905509 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 3.3616140617
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3616039940
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012871 Skin Diseases Arsenic 5.5817548696 18709164 15952646 19834688 17938729 16759981 16702368 6392382 16353154 17453740 17050553
MESH:D012871 Skin Diseases monomethylarsonous acid 5.5817431481
MESH:D012878 Skin Neoplasms Arsenic 10.1519538983 17050553 15504454 17976673 17029826 16251483
MESH:D012878 Skin Neoplasms sodium arsenite 10.1519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1516192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 9.0819429237 11144890 18640142 17976673 17306315 19322015 15987713
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 9.0820375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 9.0817306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014652 Vascular Diseases Arsenic 13.2117056641
MESH:D014652 Vascular Diseases sodium arsenite 13.2117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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