AutismKB 2.0

Annotation Detail for PDE1A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDE1A ( HCAM1,HSPDE1A,MGC26303 )
Gene Full Name: phosphodiesterase 1A, calmodulin-dependent
Band: 2q32.1
Quick LinksEntrez ID:5136; OMIM: 171890; Uniprot ID:PDE1A_HUMAN; ENSEMBL ID: ENSG00000115252; HGNC ID: 8774
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa00230Purine metabolism
hsa04742Taste transduction
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Hemostasis
Opioid Signalling
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
1918Atherosclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PDE1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE1A mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PDE1A mRNAincreases expression 17879257
D003976 Diazinon Diazinon results in decreased expression of PDE1A mRNAdecreases expression 17452286
D004041 Dietary Fats Dietary Fats results in decreased expression of PDE1A mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDE1A mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of PDE1A mRNAdecreases expression 18035473
D017328 Fosinopril Fosinopril affects the expression of PDE1A mRNAaffects expression 18209565
D017328 Fosinopril Fosinopril affects the expression of PDE1A proteinaffects expression 18209565
D006152 Cyclic GMP PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]decreases reaction|increases abundance 11696475
D005996 Nitroglycerin Nitroglycerin results in increased expression of PDE1A mRNAincreases expression 11696475
D005996 Nitroglycerin Nitroglycerin results in increased expression of PDE1A proteinincreases expression 11696475
D005996 Nitroglycerin PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]decreases reaction|increases abundance 11696475
C076029 olanzapine olanzapine results in increased expression of PDE1A mRNAincreases expression 20222156
C041786 palm oil palm oil results in decreased expression of PDE1A mRNAdecreases expression 18042831
D010656 Phenylephrine PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]decreases activity|increases reaction 19797176
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDE1A mRNAaffects cotreatment|increases expression 17942748
D014501 Uranium Uranium affects the expression of PDE1A mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of PDE1A mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.3516487989
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1117460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder olanzapine 2.3517069543 18685284
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8120146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8120435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D006332 Cardiomegaly Phenylephrine 6.8915728586 17287366 17124262 11179087 11754973 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002389 Catatonia olanzapine 6.2818071103 16772815
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8817110522 16919318 17333356 16105132 15861022 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D002658 Developmental Disabilities olanzapine 4.6917069543
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5612594235 16081117 19420014 16177239 2444490 12958197 16393943 12705907 17562736 10663392 12153990 19085960 19923254 16781746 15619225 11529661 16485898 12540782 18713872 16109766 14550746 17522070 19370779 11421492 11739529 17906064 15968718 10915739 12392966 11834606 11743745 16227642 10774834 19739265 19164858 11287661 11461765 18071297 19416960 14986274 14725611
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004417 Dyspnea Diazinon 4.8316487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Dietary Fats 7.7318296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Dietary Fats 8.6718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6720067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006261 Headache Nitroglycerin 5.2211284996 11554966
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Diazinon 4.5816487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006963 Hyperphagia olanzapine 6.2517933447
MESH:D006973 Hypertension Fosinopril 9.027720355
MESH:D006973 Hypertension Phenylephrine 9.0212717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.0218670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.5612791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Diazinon 6.9512948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9517937319
MESH:D007249 Inflammation Dietary Fats 8.3220412841
MESH:D007249 Inflammation Flavonoids 8.3217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3212878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.1118457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2015629191 12587719
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8818296743
MESH:D008106 Liver Cirrhosis, Experimental Fosinopril 3.2817900296
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319014921 16611625 19460945 16610002 19784758 12587719 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.3320195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1112151625
MESH:D008133 Long QT Syndrome olanzapine 4.7320210726
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1820135361 18569708 6695378 18816296 18520028 20869020 20064080 20464547 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1819555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D001523 Mental Disorders olanzapine 4.6616856516
MESH:D008659 Metabolic Diseases olanzapine 5.3919142110
MESH:D008708 Methemoglobinemia Nitroglycerin 4.743537620
MESH:D020326 Migraine without Aura Cyclic GMP 11.5111304026
MESH:D020326 Migraine without Aura Nitroglycerin 11.5114659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009203 Myocardial Infarction Nitroglycerin 3.7814729435
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1711141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity Dietary Fats 5.1320132043 21332399 18674790 17217161 20518802 19632207 11836018 16723640 18457598
MESH:D009765 Obesity olanzapine 5.1318515891
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D011041 Poisoning Diazinon 4.3617603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9817292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011595 Psychomotor Agitation olanzapine 5.6018685284
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012559 Schizophrenia olanzapine 3.4317726453 20521326 20107430
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D017180 Tachycardia, Ventricular olanzapine 5.3420210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1817053015
MESH:D014570 Urologic Diseases Diazinon 5.3116487989
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 10.0916723640
MESH:D015430 Weight Gain olanzapine 10.0919434072 17933447 20107430
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:604 Hemostasis
REACT:15295 Opioid Signalling
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
KEGG:04742 Taste transduction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33122
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00622 inhibitor Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB01023 antagonist Lexxel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Dihydropyridines
    DB01244 antagonist Bepridil Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved