AutismKB 2.0

Annotation Detail for CDC40


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Basic Information Top
Gene Symbol:CDC40 ( EHB3,FLJ10564,MGC102802,PRP17,PRPF17 )
Gene Full Name: cell division cycle 40 homolog (S. cerevisiae)
Band: 6q21
Quick LinksEntrez ID:51362; OMIM: 605585; Uniprot ID:PRP17_HUMAN; ENSEMBL ID: ENSG00000168438; HGNC ID: 17350
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
500570Cleavage of Growing Transcript in the Termination Region
500928Transport of Mature mRNA derived from an Intron-Containing Transcript
500105mRNA 3'-end processing
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002945 Cisplatin Cisplatin results in increased expression of CDC40 proteinincreases expression 16803524
D005472 Fluorouracil Fluorouracil results in increased expression of CDC40 proteinincreases expression 16803524
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.5112690470 17670903 15814532
MESH:D000230 Adenocarcinoma Cisplatin 5.0017638652 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 5.0017638652
MESH:D000740 Anemia Fluorouracil 4.2217963324 16511603 15504547
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.9514601052
MESH:D001943 Breast Neoplasms Cisplatin 2.4218382427 19526202
MESH:D001943 Breast Neoplasms Fluorouracil 2.4216557594 18357371 19217205 16110121 15136595 16595493 18608205
MESH:D002276 Carcinoid Tumor Fluorouracil 5.7416051944
MESH:D002277 Carcinoma Fluorouracil 3.9717121937
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.4917982673
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.4917971768 17045692 17088986 16332177 18930000 16799960
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1616685392 12023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.2018695887
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.296189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.2916757204 16280240 18986760 17066447
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2915001691 17172411 16510598 18772588 17725105 17016597 16340194 17287894 17018589 17169374
MESH:D015179 Colorectal Neoplasms Cisplatin 2.8015273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8020501625 18509181 16391804 17454858 16282729 18802399 17016601 17255274 15289873 17695437 17594712 16524972 18448328 14970324 18949393 17094418 18288408 15148649 16303861 18383874 17401013 16331619
MESH:D007644 Darier Disease Fluorouracil 5.6816733453
MESH:D004362 Drug Toxicity Cisplatin 4.2212231392 19839026 15033597 12649298
MESH:D004938 Esophageal Neoplasms Cisplatin 5.0916481741 15464296 16785472 15173087 17638652
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.0916337965 16785472 16481741 15173087 17638652
MESH:D005910 Glioma Fluorouracil 3.0216145905
MESH:D006258 Head and Neck Neoplasms Cisplatin 9.0415464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 9.0415162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 4.7719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.8615464296
MESH:D006689 Hodgkin Disease Cisplatin 4.0616200630 16170182
MESH:D007673 Kidney Cortex Necrosis Cisplatin 6.2115464296
MESH:D007674 Kidney Diseases Cisplatin 3.4815190930 12649298 18289764 19839026 12231392
MESH:D007680 Kidney Neoplasms Fluorouracil 3.7416985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.8611231351
MESH:D008113 Liver Neoplasms Fluorouracil 2.6216603448 17045692 15113037 18383874
MESH:D008175 Lung Neoplasms Cisplatin 2.8517225452 11798837 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 2.8515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.6815086387
MESH:D008545 Melanoma Cisplatin 2.5218505091 16248763 12393984 18176117 17023156 11135225 16432458 12883367 15577323 18332650 16809738 12374674 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.6615990972
MESH:D008654 Mesothelioma Cisplatin 3.3917638057
MESH:D009062 Mouth Neoplasms Fluorouracil 4.0216757204 18986760
MESH:D009369 Neoplasms Cisplatin 6.0316773208
MESH:D009369 Neoplasms Fluorouracil 6.0316928823 18600527 18239605
MESH:D009395 Nephritis, Interstitial Cisplatin 5.5615464296
MESH:D009447 Neuroblastoma Cisplatin 3.668761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.588761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.7516436463
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9917225452 6897625 15464296 19769630
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.9919003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.9915113037 19003803 16500647 16929163
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.9815464296
MESH:D010997 Pleural Neoplasms Cisplatin 6.4117638057
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3419082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.4816160472 18286688 18722050 15538739
MESH:D051437 Renal Insufficiency Cisplatin 5.1715464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 5.1014601052
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 6.4115464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.7918396642 17522103 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7918396642 17498489 18567086 16424979 19084572 17522103 15786421 16951190 19015929 17172411
MESH:D013736 Testicular Neoplasms Cisplatin 5.2415464296 17225452
MESH:D014062 Tongue Neoplasms Fluorouracil 4.5016280240
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0912973940 15464296 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 11.3816803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 11.3816803524
MESH:D014625 Vaginal Neoplasms Cisplatin 5.3715577323
MESH:D014839 Vomiting Cisplatin 5.7911897121
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
REACT:78 Post-Elongation Processing of the Transcript
KEGG:03040 Spliceosome
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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