AutismKB 2.0

Annotation Detail for PLA1A


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Basic Information Top
Gene Symbol:PLA1A ( PS-PLA1,PSPLA1 )
Gene Full Name: phospholipase A1 member A
Band: 3q13.33
Quick LinksEntrez ID:51365; OMIM: 607460; Uniprot ID:PLA1A_HUMAN; ENSEMBL ID: ENSG00000144837; HGNC ID: 17661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P057262-arachidonoylglycerol biosynthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PLA1A mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PLA1A proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLA1A mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLA1A mRNAaffects cotreatment|increases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLA1A mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in increased expression of PLA1A mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in increased expression of PLA1A mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PLA1A mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PLA1A mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLA1A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLA1A mRNAaffects cotreatment|increases expression 18164116
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLA1A mRNAincreases expression 17321000
C041786 palm oil palm oil results in decreased expression of PLA1A mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of PLA1A mRNAdecreases expression 17681415
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLA1A mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of PLA1A mRNAdecreases expression 17321000
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in decreased expression of PLA1A mRNA]affects reaction|decreases expression 17321000
C025643 vinclozolin vinclozolin affects the expression of PLA1A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.2411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.2418653653
MESH:D000236 Adenoma beta-Naphthoflavone 6.9819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3716434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3716434500
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1817474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8516011737 15721981 16097048 16227642 16192424 16124888 16050911 15673190 10355542 15700767 18705752 3786805
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.633084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6317428255 19052882 20524982 19383236 17138121 16569478 19335982 19539802 16540662 18056438 18691550 20727157 18494052 18210153 20432363 20512989 17761372 19418558 11831363 18665156 16681979 19919837 21159647 16935385 19519916 16878318 17978847 17162532 20935162 17055752 16779866 20101231 18506893 18971187 18978308 10737359 19822196 19107877 19171122 10672840 20084675 3084413 16288022 20214788 19394651 19208518 3581430 20514400 16830150 16328049 20007298 18393292 18785209 16502159 17173139 18788625 16807293 19701751 16698587
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.7317174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2815619225 2444490 19739265 18071297 10915739 19416960 12705907 19164858 15968718 10774834 19420014 18713872 16081117 14550746 17906064 11461765 17522070 19923254 16109766 12594235 11834606 12153990 16177239 12540782 14986274 11529661 11287661 16393943 12392966 14725611 16227642 17562736 12958197 19370779 11421492 11743745 19085960 16485898 10663392 11739529 16781746
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.2821278145 3732212 2869522 6884620 10915739 7120509 17522070 3786805 9327722 6623471 16227642 19336974 15027814 15998439 10092053 16177239 4309450 7440962 15968718 11566570 19085960 7179309
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2819107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004487 Edema perfluorooctanoic acid 7.1617259670 12083418
MESH:D004487 Edema pirinixic acid 7.1612083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4815821434 17637181 15328337
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.2712795759 15959796 61145 16239168 19224547 17595544 12631006 16045604
MESH:D005234 Fatty Liver Cyclosporine 25.2719224547
MESH:D005234 Fatty Liver Dietary Fats 25.2718296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 25.2721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 25.2719236843 20131406
MESH:D005334 Fever Lipopolysaccharides 4.0611852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 15.2318705752
MESH:D005355 Fibrosis Cyclosporine 15.2312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.2318296743
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 8.953609246
MESH:D006529 Hepatomegaly pirinixic acid 8.9519176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.0012083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007248 Infertility, Male vinclozolin 3.0716467254
MESH:D007249 Inflammation Dietary Fats 12.2620412841
MESH:D007249 Inflammation Diethylnitrosamine 12.2618785209
MESH:D007249 Inflammation Lipopolysaccharides 12.2617237260 17255318 12878042 9205823 17963957
MESH:D007249 Inflammation perfluorooctanoic acid 12.2612083418
MESH:D007333 Insulin Resistance Dietary Fats 7.3618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.3616306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 13.228812269
MESH:D007984 Leydig Cell Tumor vinclozolin 13.2216417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.1911408273 11903743 16943688 17157831 21278145 17334410 16221502 17174718 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 11.1918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.1918522880 18665156 19638242 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5615730626 14724832 12667390 20821823 18156304 18420326 17721639 18187930 17805973 17900296 18472332 15996030 10355542 15052691 17640975 18395095 18429990 18481824 17525996 17869086 18418968 17944888 17823541 16116963 12898905 16638106 18205269 17922224 17557913 17631135 12546737 15370692 18395914 17698563 17714472 18472094 18210741 12958196 18412020 15362042 18376398 17976157 16027843 18166357 12445418 12741479 16015684 14716833 15673190 15931870 14716496 18279442 17708605 18339082 13678700 15650968 12632514 16033810 18277467 16192424 18251166 17565644 16248980 18006644 12666154 16136751 15876570 14512876 14748882 17481882 15338365 15123356 15818738 15925388 12445421 12586293 17761835 18317297 18263696 15959796 12632512 12389079 12649538 15893842 18054572 16011737 12609069 18705752 15057751 14620537 17766677 11481614 16097048
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5612878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008107 Liver Diseases Acetaminophen 6.5519014921 19784758 11587558 19460945 16610002 12969438 16611625 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5516964402 17285989 15720792 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5517034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5816899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.262125692 9163691 15890375 18177683
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.2621295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.2619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.2619638242 15885732 9163691 18648771 16942905 18754104 19642983 19551842 19996281 18977376 12771043 19690152 21278145 2422723 19255062 20501860 20452335 19294768 21071580 18644402 19812893 18978307 20492335 20118626 10737359 19426721 20137499 15175105 21167192 19850985 19499222 19254457 21047994 19090486 20583210 20101389 12112319 20434301 19073162 19256749 19427195 19833225 20405173 2862719
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 18.2614757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 18.2616377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.448603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.4418164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.4412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.4417174075 18282651 19009564 19519916 17854601 19004024 18775883 18079962 16267830 19126423 21159647 16842330 19539802 18093689 2563599 18308698 3124819 9362446 18544905 18253720 17942915 18164116
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5014755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5020970405 20512841 21163286 6695378
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 3.6612807724
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.029802331
MESH:D009765 Obesity Dietary Fats 4.4719632207 18457598 18674790 16723640 21332399 20132043 20518802 17217161 11836018
MESH:D009765 Obesity pirinixic acid 4.4720558911
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D011014 Pneumonia Lipopolysaccharides 4.6412224865 11605937
MESH:D011230 Precancerous Conditions Cyclosporine 9.1012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.102563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 10.2117132714
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2119015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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