AutismKB 2.0

Annotation Detail for PDE1C


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Basic Information Top
Gene Symbol:PDE1C ( Hcam3 )
Gene Full Name: phosphodiesterase 1C, calmodulin-dependent 70kDa
Band: 7p14.3
Quick LinksEntrez ID:5137; OMIM: 602987; Uniprot ID:PDE1C_HUMAN; ENSEMBL ID: ENSG00000154678; HGNC ID: 8776
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa00230Purine metabolism
hsa04740Olfactory transduction
Pathway IDPathway Name
Signalling by NGF
Opioid Signalling
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PDE1C mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE1C mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos affects the expression of PDE1C mRNAaffects expression 17452286
D016572 Cyclosporine Cyclosporine results in increased expression of PDE1C mRNAincreases expression 20106945
D003976 Diazinon Diazinon affects the expression of PDE1C mRNAaffects expression 17452286
D017328 Fosinopril Fosinopril affects the expression of PDE1C mRNAaffects expression 18209565
D017328 Fosinopril Fosinopril affects the expression of PDE1C proteinaffects expression 18209565
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PDE1C mRNAincreases expression 12057914
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3311850527 18653653
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 10.5217119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 10.5216487989
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6512705907 16781746 16081117 10663392 11287661 12540782 19739265 14550746 19923254 19416960 16109766 19164858 15619225 12392966 19420014 19370779 12958197 12594235 17906064 10774834 11421492 17562736 11834606 14725611 2444490 12153990 14986274 16393943 15968718 11461765 19085960 11743745 17522070 11739529 16227642 18713872 18071297 11529661 10915739 16485898 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004417 Dyspnea Diazinon 5.2416487989
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7917637181 15821434 15328337
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005334 Fever Lipopolysaccharides 4.289205823 11852909
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6516366002
MESH:D006505 Hepatitis Diazinon 4.9016487989
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Cyclosporine 6.4210903974
MESH:D006973 Hypertension Fosinopril 6.427720355
MESH:D007248 Infertility, Male Diazinon 3.9916466525 12948887
MESH:D007249 Inflammation Lipopolysaccharides 2.9912878042 17237260 9205823 17963957 17255318
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9317255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.288314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007970 Leukopenia Lipopolysaccharides 5.0915821434
MESH:D008106 Liver Cirrhosis, Experimental Fosinopril 3.7217900296
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.7212878042
MESH:D008107 Liver Diseases Acetaminophen 4.4611587558 16611625 19460945 19784758 12587719 12969438 19014921 16610002
MESH:D008107 Liver Diseases Chlorpyrifos 4.4615991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D055370 Lung Injury Lipopolysaccharides 4.3621114838
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3415081274
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D011014 Pneumonia Lipopolysaccharides 4.9512224865 11605937
MESH:D011041 Poisoning Diazinon 4.6517603234
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9010835634
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.9917119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.3316611668 17119214
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.536418539
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4315821434
MESH:D014570 Urologic Diseases Diazinon 5.7216487989
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04740 Olfactory transduction
REACT:15295 Opioid Signalling
KEGG:00230 Purine metabolism
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33124
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA449233desipramine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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