AutismKB 2.0

Annotation Detail for UCHL5


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Basic Information Top
Gene Symbol:UCHL5 ( CGI-70,INO80R,UCH37 )
Gene Full Name: ubiquitin carboxyl-terminal hydrolase L5
Band: 1q31.2
Quick LinksEntrez ID:51377; OMIM: 610667; Uniprot ID:UCHL5_HUMAN; ENSEMBL ID: ENSG00000116750; HGNC ID: 19678
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of UCHL5 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of UCHL5 mRNAaffects expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of UCHL5 mRNAincreases expression 20458559
D016572 Cyclosporine Cyclosporine results in increased expression of UCHL5 mRNAincreases expression 20106945
C051890 irinotecan irinotecan metabolite results in decreased expression of UCHL5 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of UCHL5 mRNAdecreases expression 15956246
D018038 Sodium Selenite Sodium Selenite results in increased expression of UCHL5 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.817296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8114691202 16217749 15553829 15073043 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.386135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.3812371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.659022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003110 Colonic Neoplasms irinotecan 2.6317725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7420501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7416391804 16303861 17159606 17454858 18509181 18259882 15273666
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2118759878 11298694 8156756 14531868 11906362 2524372 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.726482804 6679447 8291058 1440618 9653073 16192314 9022650 7440962 11289319 9328219 18289764 18692083 18648102
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.7215131321
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.693581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6912903497
MESH:D005234 Fatty Liver arsenic trioxide 8.8515073043
MESH:D005234 Fatty Liver Cyclosporine 8.8519224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.976582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1817050201 20471514 16467208 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4115213294 12712474 17649720 17712046 16823087 19035177 16891316 16112521 19075265 19642359 15622746 16330433 17869043 11161223 17217047 11468182 16966277 9834237 15336539 16331271 19225113 12679006 15748426 17107899 12018890
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.937678174
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9314682389
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.946135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.94598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.9420377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D052016 Mucositis irinotecan 5.4717159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219417148 14977855 15949261 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016105982 16882451
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.327678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.273581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.2718259882
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.906679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D009447 Neuroblastoma irinotecan 3.628761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.198761367
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9116049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.916482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4819769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2618760546
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7217007042
MESH:D013274 Stomach Neoplasms irinotecan 2.7215723263
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.976587162 1399818 6582329 3712494 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.918074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9112973940 12845720 11780464 20435036
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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