AutismKB 2.0

Annotation Detail for PDE3A


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Basic Information Top
Gene Symbol:PDE3A ( CGI-PDE )
Gene Full Name: phosphodiesterase 3A, cGMP-inhibited
Band: 12p12.2
Quick LinksEntrez ID:5139; OMIM: 123805; Uniprot ID:PDE3A_HUMAN; ENSEMBL ID: ENSG00000172572; HGNC ID: 8778
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04910Insulin signaling pathway
hsa00230Purine metabolism
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
height
QT interval
male infertility
Aortic root size
DEVELOPMENTAL
REPRODUCTION
Desease Name
Height
QT interval
Male infertility
Aortic root size
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE3A mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE3A mRNAdecreases expression 19150397
D015124 8-Bromo Cyclic Adenosine Monophosphate 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PDE3A mRNAincreases expression 12466227
D003976 Diazinon Diazinon affects the expression of PDE3A mRNAaffects expression 17452286
C459562 L-826,141 L-826,141 results in decreased activity of PDE3A proteindecreases activity 15901792
C059498 olprinone olprinone results in decreased activity of PDE3A proteindecreases activity 16325808
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDE3A mRNAaffects binding|increases activity|increases expression 19710929
C424423 Roflumilast Roflumilast results in decreased activity of PDE3A proteindecreases activity 15901792
C035964 trequinsin trequinsin results in decreased activity of PDE3A proteindecreases activity 15901792
C081489 valsartan valsartan results in increased expression of PDE3A mRNAincreases expression 19027736
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.5716487989
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D006332 Cardiomegaly valsartan 4.2719597038
MESH:D009202 Cardiomyopathies valsartan 4.5416247790
MESH:D002318 Cardiovascular Diseases valsartan 4.4111230374
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8420889678
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003324 Coronary Artery Disease valsartan 3.9517719468
MESH:D003384 Coxsackievirus Infections valsartan 6.0820392896
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.7411508273
MESH:D003928 Diabetic Nephropathies valsartan 4.9411427623 18630688
MESH:D004417 Dyspnea Diazinon 5.0616487989
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver pirinixic acid 2.9319236843 20131406
MESH:D005355 Fibrosis valsartan 4.9816893502
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.7416928621
MESH:D006333 Heart Failure pirinixic acid 7.7220558911
MESH:D006333 Heart Failure valsartan 7.7219027736
MESH:D006505 Hepatitis Diazinon 4.7716487989
MESH:D006529 Hepatomegaly pirinixic acid 3.2119176532 16221962 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension valsartan 3.7816475468 18344623 11427623 20102058 10903974 12850387 18390891 12692753
MESH:D006974 Hypertension, Malignant valsartan 6.6811560862
MESH:D007248 Infertility, Male Diazinon 3.9312948887 16466525
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007674 Kidney Diseases valsartan 4.0510903974 12164870 16893502
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.8515474484
MESH:D008106 Liver Cirrhosis, Experimental valsartan 2.8515504291 15619341 16872305
MESH:D008113 Liver Neoplasms pirinixic acid 1.8716377806 15890375 20007298
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction marker/mechanism 19027736
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D011041 Poisoning Diazinon 4.5317603234
MESH:D011507 Proteinuria valsartan 5.0417664856 18344623 12164870
MESH:D011658 Pulmonary Fibrosis valsartan 3.8717241526
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D014570 Urologic Diseases Diazinon 5.5416487989
MESH:D020257 Ventricular Remodeling valsartan 5.9419027736
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33126
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA449233desipramine
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00235 inhibitor Milrinone Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors;Cardiotonic Agents
    DB00261 inhibitor Anagrelide Antithrombotic Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00277 antagonist Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00922 antagonist Levosimendan Vasodilator Agents;Phosphodiesterase Inhibitors;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB01166 antagonist Cilostazol Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Neuroprotective Agents
    DB01223 antagonist Quiex-Pred Sus Phosphodiesterase Inhibitors;Bronchodilator Agents;Cardiotonic Agents;Respiratory Smooth Muscle Relaxants
    DB01303 antagonist Oxtriphylline Bronchodilator Agents
    DB01427 antagonist Amrinone Vasodilator Agents;Phosphodiesterase Inhibitors;Cardiotonic Agents;Calcium Channel Blockers
    DB04880 antagonist Enoximone Vasodilator Agents;Phosphodiesterase Inhibitors;Cardiotonic Agents
    DB05266 antagonist Ibudilast Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors;Bronchodilator Agents
    DB08811 inhibitor Tofisopam Benzodiazepines
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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